Search PubMed⌕ Search

Biomedical subjects

C Beard

Publications and source records attributed to C Beard.

At least 55 records · Page 3Linked to original sources
PubMed1988

Full-thickness unipedicle flap for lower eyelid reconstruction.

We developed a technique for lower eyelid reconstruction using a full-thickness unipedicle flap from the upper tarsal portion of the upper eyelid. The lost tissue is replaced with identical tissue from the ipsilateral upper eyelid. The technique is best suited to shallow defects of the temporal lower eyelid. The levator aponeurosis and Müller's muscle are recessed to avoid upper eyelid retraction. The key to performing this operation is a thorough knowledge of eyelid anatomy and preservation of its microvascular supply. This procedure has produced satisfactory to excellent results in 17 patients and offers the reconstructive surgeon several advantages over other techniques.

Eyelid Neoplasms↗
PubMed1987

In vitro identification of a B19 parvovirus promoter.

The nucleotide sequence of the B19-Wi isolate of human parvovirus was determined and compared throughout the open reading frames and putative transcription signals with the sequence of the closely related B19-Au isolate. In vitro run off transcription assays, using B19-Wi DNA as the template, indicated that there is a strong promoter between m.u. 5 and 7. Deletion clones show that a region between nt 258 and 321 is necessary for in vitro transcriptional activity. Primer extension studies identified the start site at 31-32 nucleotides downstream of the sequence TATATATA. The strength of this left-hand promoter is unusual among parvovirus promoters characterized to date, and the possibility of an upstream enhancer element is discussed.

Base Sequence↗
PubMed1986

Are there compartment syndromes in some patients with idiopathic back pain?

Palpable rigidity of the epaxial (paraspinal) muscles, lordotic flattening, and spinal flexion accompanying back pain generally are ascribed to epaxial muscle spasm. However, palpable rigidity without muscle spasm occurs in compartment syndromes and epaxial muscle contractions extend the spine, increasing lordosis. Epaxial compartment syndromes are proposed as a possible cause of palpable rigidity, lordotic flattening, and spinal flexion accompanying idiopathic back pain. This article demonstrates the following: existence of an epaxial compartment by latex and dye injections; simulation of epaxial compartment syndromes in unembalmed cadavers by saline injections; and a "Bourdon tube effect" producing spinal flexion with lordotic flattening during epaxial compartment syndrome simulation in embalmed cadavers. In addition, resting and exercising epaxial compartment pressures were measured in 18 normal volunteers with a slit catheter.

Aged↗
PubMed1985

Müller's superior tarsal muscle: anatomy, physiology, and clinical significance.

Müller's superior tarsal muscle has been extensively studied by anatomists and physiologists but has been largely ignored by surgeons. This muscle is considered from the standpoint of both gross and finer anatomy. Concepts regarding the uncertain course of its sympathetic nerve supply fibers are reviewed, and "semi-conclusions" are given. The physiology of the muscle, both normal and pathological, is considered in view of both accepted and controversial concepts. Methods of weakening an overactive Müller's muscle medically and surgically are discussed. Some methods that have attempted to utilize the lid-elevating power of Müller's muscle are described, and the muscle's potential in this regard is considered. This small muscle is deserving of more appreciation and of a higher surgical status than it has received in the past.

Adult↗
PubMed1985

Isolation and characterization of the SPT2 gene, a negative regulator of Ty-controlled yeast gene expression.

The his4-917 mutation of Saccharomyces cerevisiae results from the insertion of the Ty element Ty917 into the regulatory region of the HIS4 gene and renders the cell His-. The hist4-912 delta mutant, which carries a solo delta in the 5'-noncoding region of HIS4, is His+ at 37 degrees C but His- at 23 degrees C. Both these mutations interfere with HIS4 expression at the transcriptional level. The His- phenotype of both insertion mutations is suppressed by mutations at the SPT2 locus. The product of the wild-type SPT2 gene apparently represses HIS4 transcription in these mutant strains; this repression is relieved when the SPT2 gene is destroyed by mutation. The repression of transcription by SPT2 presumably results from an interaction between the SPT2+ gene product and Ty or delta sequences. In this paper, we report the cloning and DNA sequence analysis of the wild-type SPT2 gene and show that the gene is capable of encoding a protein of 333 amino acids in length. In addition, we show that a dominant mutation of the SPT2 gene results from the generation of an ochre codon which is presumed to lead to a shortened SPT2 gene product.

Amino Acid Sequence↗
PubMed1981

Changes in the association between Bacillus subtilis RNA polymerase core and two specificity-determining subunits during transcription.

The Bacillus subtilis RNA polymerase sigma subunit and the phage SPO1-coded gene 28 protein are responsible for selective binding of RNA polymerase to early and middle SPO1 promoters, respectively. The association of the RNA polymerase core with each of these subunits weakens during the elongation of RNA chains. Similar changes are known to be an essential part of the Escherichia coli RNA polymerase sigma cycle.

Aurintricarboxylic Acid↗
PubMed1981

Orbital melanocytic hamartoma.

A male Chinese neonate had a melanocytic hamartoma that involved the entire orbit and the eye, but did not involve the orbital bones or eyelid skin. Although usually benign, these hamartomas may be locally invasive, and rare cases of malignant transformation have occurred.

Cornea↗
PubMed1980

Dystrophic degeneration of papillary muscle and ventricular myocardium. A basis for mitral valve prolapse in Duchenne's muscular dystrophy.

The hearts of three children who died with Duchenne's progressive muscular dystrophy and features of mitral valve prolapse were examined to find if the valve disorder arose from cardiomyopathy due to the primary disease or from dystrophic changes in th mitral valve itself. Gross, histologic and ultrastructural features of mitral valve annulus, anterior and posterior leaflets, chordae tendineae, right and left ventricles, and anterior and posterior papillary muscles were compared with those of similar tissues from normal children of matched age and sex. Fibrosis and myofibrillar lysis--most extensive in posterior papillary muscle and in the posterobasal segment of the left ventricle--were the main histopathologic findings. Myofibrillar lysis was characterized by a total loss of actin and myosin myofilaments. By contrast, the mitral valve annulus, its leaflets and the origin, distribution pattern, length and thickness of chordae tendineae were entirely normal. These observations establish that mitral valve prolapse syndrome in Duchenne's dystrophy is an expression of cardiomyopathy involving papillary muscle and ventricular myocardium rather than a result of dystrophic changes in the mitral valve leaflets, annulus or chordae tendineae.

Adolescent↗
PubMed1979

Split-level full-thickness eyelid graft.

A new method of surgical treatment for cicatricial eyelid retraction involves grafts placed in both the anterior and posterior lamellae of the upper eyelid, when there is a shortage of tissue in both layers, caused by previous surgical procedures. The anterior lamellar graft is of postauricular skin and the posterior graft is of buccal mucosa. The two grafts are placed at different levels in the eyelid so that each has a viable vascular bed. The procedure, called the split-level full-thickness eyelid graft, is not designed to correct problems involving only the eyelid retractors, such as retraction secondary to thyroid disease.

Blepharoptosis↗
PubMed1979

Terminal course of nerve supply to Müller's muscle in the rhesus monkey and its clinical significance.

Electron microscopic, histochemical fluorescence, and pharmacologic evidence suggested that, in the rhesus monkey, Müller's muscle was not totally denervated either by cutting the levator palpebrae superioris muscle or by a Fasanella-Servat procedure. We examined the terminal course of the sympathetic nerve supply and the potential for preserving Müller's muscle in blepharoptosis surgery.

Adrenergic Fibers↗
PubMed1979

Blepharochalasis.

The condition of blepharochalasis and its treatment are discussed. Four cases are presented which show a physical sign that may help in its diagnosis.

Adolescent↗
PubMed1979

[Acquired ptosis].

Explore the source record for details and available documents.

Blepharoptosis↗