Biomedical subjects

C Basile

Publications and source records attributed to C Basile.

51 records · Page 3Linked to original sources

PubMed1980

Carnitine improves lipid anomalies in haemodialysis patients.

51 chronic haemodialysis patients with hypertriglyceridaemia were given a daily oral dose of 2.4 g D,L-carnitine for 30 days to investigate a possible hypolipaemic effect. After 30 days' D,L-carnitine treatment the mean (+/- SEM) serum triglyceride concentration had decreased significantly from 3.50 +/- 0.39 to 2.87 +/- 0.27 mmol/l. Serum total cholesterol did not change. However, HDL cholesterol increased significantly from 0.89 +/- 0.05 to 1.35 +/- 0.07 mmol/l. This decrease in serum triglycerides and return of HDL cholesterol to normal levels in haemodialysis patients may be the result of correction of carnitine deficiency. Such treatment could reduce the risk factors for atherosclerosis and coronary-artery disease in uraemic patients.

Adult↗

PubMed1980

Improvement of post-heparin lipolytic activity (PHLA) after haemofiltration, in uraemic patients.

UNLABELLED: The decrease of serum PHLA in uraemic patients has been attributed to toxic effects of 'middle molecules' on lipoprotein lipase. Haemofiltration could improve PHLA by increasing 'middle molecule' clearance. Serum triglyceride concentration decreased and PHLA improved in three uraemic patients who received haemofiltration during three weeks as the initial treatment schedule. Activated PHLA of a healthy subject failed to be inhibited by uraemic sera and uraemic plasma ultrafiltrates obtained in vitro using polyacrylonitrile and cuprophane membranes. CONCLUSION: haemofiltration is able to improve PHLA and to restore normal serum triglyceride concentrations. The reported toxicity of uraemic serum may affect metabolic steps preceding the activation of the circulating lipolytic enzymes.

Blood↗

PubMed1980

[Hyperparathyroidism and anemia: experimental study in the rat (author's transl)].

Red blood cell (RBC) production has been explored in hyperparathyroid as compared to normal rats. The hyperparathyroid state was obtained by feeding the rats a calcium-deficient diet during 30 days. A significant decrease (p less than 0.001) in reticulocyte count and in erythrocyte 59Fe incorporation was observed in hyperparathyroid rats when compared to control animals. A comparable inhibition of erythrocyte 59Fe incorporation in hyperparathyroid rats was found when the study was performed after stimulating bone marrow activity by acute arterial hemorrhage. These results of decreased RBC production using a model of endogenous hyperparathyroidism could be confirmed in additional experiments using a model of exogenous hyperparathyroidism. In this model, the rats received either parathyroid extract (3 x 10 USP/day during 8 days) or vehicle only. Again, a decrease in erythrocyte 59Fe incorporation was observed in hyperparathyroid animals when compared to control animals. It is concluded that the hyperparathyroid state is accompanied by a decrease of RBC production in the rat. It is probable that a similar pathogenesis underlies the anemia of patients with primary or secondary hyperparathyroidism.

Anemia↗

PubMed1978