Biomedical subjects

C B Sarker

Publications and source records attributed to C B Sarker.

24 records · Page 2Linked to original sources

PubMed2003

Immunochromatographic (rK39) strip test in the diagnosis of visceral leishmaniasis in Bangladesh.

Immunochromatographic strip test (ICT strip test) for the diagnosis of visceral leishmaniasis was evaluated in this study in the context of a case-control study. A total sixty consecutive cases of kala-azar admitted in all four Medicine Units of Mymensingh Medical College Hospital during the period of May 2002 to February 2003 was included here. Parasitological confirmation was done by demonstration of leishmania donovani bodies in bone marrow or splenic aspiration in all cases. A total 120 controls was taken of which sixty were asymptomatic endemic controls with no previous history of kala-azar and sixty were admitted patients suffering from diseases other than kala-azar (malaria, tuberculosis, enteric fever and chronic liver disease). ICT strip test for kala-azar was done in all cases and controls. Only 2 of the confirmed kala-azar cases were negative and the remaining 58 cases were positive for ICT strip test which gives the sensitivity of this test 96.6%. Among the controls, 118 were negative for ICT strip test and two of the asymptomatic controls were positive for this test with no clinical evidence of kala-azar. So, the estimated specificity of ICT strip test is 98.3%. The predictive value for a negative result was 98.3% and for a positive result was 96.6%. The ICT strip test is easy, quick, requires no technical facilities with higher sensitivity and specificity entails it to be the ideal test for the diagnosis of kala-azar in field level.

Adult↗

PubMed2003

Hairy cell leukaemia with advanced treatment - a case report.

A case of hairy cell leukaemia (HCL), a rare leukaemia, is reported here. The patient was presented with high grade continuous fever with left upper abdominal discomfort for 6 days. He was moderately anaemic, had no peripheral lymphadenopathy with mild hepatosplenomegaly. He was anaemic (Hb-7.8 gm/dl), total leukocyte count was 20 x 109/L. Peripheral blood film showed lymphocytosis (92%) with neutropenia (8%) and absolute neutophil count (ANC) was 1 x 109/L. On review, 88% of the peripheral cells had peripheral hairy projections resembling hairy cell (HC). Bone marrow examination was consistent with HCL (morrow hairy cell = 52%) including marker studies. Tartrate resistant acid phosphatase test (TRAP) was also positive. He had opportunistic mycobecterial infection giving a positive bronchial lavage for acid fast bacilli. After controlling the infection he was advised a single dose chemotherapy of 2-chlorodeoxyadenosine (2-CDA). After that he was in partial remission and after 25 months clinical and pathological relapses occurred and a second dose of 2-CDA was given and the patient went into complete remission.

Adult↗

PubMed2003

A case report on Wilson's disease.

A case of Wilson's disease, a rare autosomal recessive disorder of copper metabolism is reported here. The patient was presented with the difficulty in speech and writing for 4 years and also on walking for 1 year. He also noticed difficulty to perform any work by hands for 6 months. He had splenomegaly and bilateral gynaecomastia. His speech was low volume slurred and monotonous, muscle tone was mildly increased, and gait was limping. Slit lamp examination of eye revealed bilateral Kayser-Fleischer ring with normal visual acuity. Investigations revealed low serum albumin(26 gram/L), increased alanine trans-aminase ( A.L.T=57 U/L). Ultrasonogram of hepatobiliary system revealed coarse hepatic tissue echotexture with splenomegaly. Liver scan showed slightly nonuniform radiotracer distribution in the liver, there was slight increased bony uptake. Serum caeruloplasmin level was 11.51 mg/dl. 24 hours urinary copper excretion was 150 microgram per day. Liver biopsy revealed cirrhotic change. Now he was advised for taking copper chelating agent (penicillamine) in a dose of 1 gram/day.

Adolescent↗

PubMed2002

Extrapulmonary tuberculosis in surgical specimens.

Tuberculosis is a very common lesion in surgical specimen in our country. This study was designed to explore the distribution of extrapulmonary tuberculosis (EPTB) in various organs through examination of surgical specimens. A total of 103 specimens were diagnosed as tubercular lesion by histological evaluation in the department of pathology, Mymensingh Medical College and a private laboratory during the period from January 1997 to August 1998. Out of 103 cases 36 were male and 67 were female (M: F = 1:1.8) and their age ranged from 4-75 years (median age 28 years). The lesions were distributed as follows: lymphnode 86 (84.9%), intestine 9 (8.7%), bone 2 (1.9%), epididymis 2 (1.9%), fallopian tube 1 (0.97%), pharynx 1 (0.97%) tonsil 1 (0.97%) and nasal mucosa 1 (0.97%). Out of 86 cases of tubercular lymphadenitis, 61 (89.7%) were cervical, 6 (6.8%) were mesenteric and 1 (1.5%) was inguinal. Sixty nine percent clinically diagnosed cases were consistent with histological findings (18 out of 26). This study reveals, in our locality, EPTB is very common in early adulthood with female preponderance. Cervical lymph node is very common sites for EPTB.

Adolescent↗

PubMed2002

Risk factors & clinical presentations--a study of eighty-five hospital admitted stroke cases.

Stroke is the commonest neurological cause of morbidity and mortality. Changes in risk factors may influence stroke incidence. Definitive diagnosis of the type of stroke is necessary for management and it has a strong impact on stroke outcome. A total of eighty-five consecutive stroke patients irrespective of age and sex admitted during the period of August 2000 to June 2001 were studied. They were asked about occupation, area of habitat, smoking habit, family history of ischaemic heart disease and/or stroke, any febrile illness, recent history of productive cough, dysuria and diarrhoea. They were searched for hypertension, diabetes mellitus, ischaemic heart disease, valvular heart disease and dislipidaemia. In every patient complete blood count, urine examination, fasting blood glucose and serum lipids, ECG, x-ray chest were performed. CT scan of brain was performed in 68 cases. Male was found 81.18% of cases with age 62.54 +/- 13.08 (m +/- SD) years. Female were 18.82% of cases with age 58.81 +/- 12.77 (m +/- SD). 75.29% of patients were belongs to middle class family. 51.76% of patients came from rural area and 48.24% of patients came from urban area. 78.82% of patients were hypertensive. Infection was associated with 37.65% of cases. Hemiplegia was commonest presentation (88.24%). Though altered consciousness was found more in haemorrhagic stroke (54.84%) but it was not significantly. High from ischaemic cases (p > 0.10) Male suffer more from stroke. Hypertension is the commonest risk factor. Infection is a common association of stroke. Altered consciousness is not a reliable guide to differentiate between ischaemic and haemorrhagic stroke is hospitalized cases.

Aged↗

PubMed2002

An evaluation of follow up program for drug addict patients.

Regular follow-up and monitoring of progress of recovery is the most important aspect of the treatment of an addict. Recovery from drug addiction is a long-term process rather than a single event. A retrospective study on 288 treated patients from the private chamber of a psychiatrist revealed that only 74 (30.32%. Patient came back for follow-up. Among the 74 patients 30 (40.54%) patients dropped out from the program within two weeks and only 18(24.32%) patients continued to attend the program at regular interval up to 3 months. Percentage of relapse was found highest during 3rd to 5th (within 2 months of discharge) follow-up visits. Majority of he patients who discontinued their follow-up program was unmarried and belongs to the lower socio-economic class.

Follow-Up Studies↗