Anti-p-azobenzenearsonate antibody of restricted heterogeneity. II. Idiotypes of antibodies produced during a 33-month period.
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
C B Alexander
Publications and source records attributed to C B Alexander.
Genetic analyses of restriction fragment length polymorphisms using high molecular weight DNA from sperm or lymphocytes embedded in agarose.
A simple and efficient method for determining restriction fragment length polymorphism types on large numbers of individuals using small samples of peripheral blood or sperm cells is described. Whole cells embedded in low gelling/melting temperature agarose were treated with a series of enzyme, detergent, and washing steps to release high molecular weight DNA that was then digested with standard restriction enzymes such as EcoRI and PstI, electrophoresed, blotted, and probed as in normal Southern analyses. The technique should be readily adaptable to any application requiring DNA from small numbers of cells for Southern analyses or pulsed field gel electrophoresis.
Animals↗
Dissecting aneurysms of the basilar artery in 2 patients.
An uncommon consequence of intracranial vascular disease is the intramural dissection of blood or "dissecting aneurysm". A 69-year-old man with chronic subarachnoid hemorrhage from a posterior fossa mass lesion and a 30-year-old man with migraine and a brain stem stroke illustrate the diverse etiologic, clinical, radiographic, and pathologic characteristics of this unusual lesion.
Aged↗
Ultrastructural heterogeneity of pulmonary scar adenocarcinomas: correlation with patients' survival.
A prospective study of 24 pulmonary scar adenocarcinomas was conducted to evaluate a potential correlation between patients' survival, propensity to metastasize, and subtypes of pulmonary scar adenocarcinomas as determined by ultrastructural examination. Ultrastructural studies of pulmonary adenocarcinomas have shown three types of cells: mucus, Clara, and alveolar, with neoplasms exhibiting these cellular components either singly or in combination. Previous studies of adenocarcinomas have revealed that tumors with Clara and alveolar cell differentiation have a better prognosis than those with a mucus cell component. The present study emphasizes clinico-pathologic correlations and indicates that pulmonary scar adenocarcinomas represent a heterogeneous group with a similar cell distribution as has been found in other pulmonary adenocarcinomas. The previously established correlation between cell types and survival remains true in this group of pulmonary adenocarcinomas. Light microscopic growth patterns and special stains (PAS and mucicarmine) were not predictable in identifying the different varieties of pulmonary adenocarcinomas.
Adenocarcinoma↗