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Biomedical subjects

C Argenson

Publications and source records attributed to C Argenson.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Vertebral hydatid cyst. Apropos of 2 cases].

The hydatid disease is rare in osseous locations, especially in our country (2.2 per cent). It has some particularities: clinical latency, diagnosis difficulties, surgical treatment often unsatisfactory because of the difficulty of total excision. Pain and sometimes deformity are often the only clinical features at the beginning of the disease. But, the evolution is unfavourable as soon as neurological symptoms appear. Multiple recurrences lead to unavoidable paraplegia. The antihelminthic drug (mebendazole) is disappointing in osseous location. Surgery is the only hope but the excision must be carcinologic. Spinal instrumentation can be improved by the use of acrylic cement whereas osseous grafts can be invaded by hydatidosis extension or recurrence. At present, the prognosis is still poor with constant apparition of cord compression. The authors report two cases of patients with osseous hydatidosis of the spine which illustrate these difficulties.

Adult↗
PubMed1988

Traumatic rotatory displacement of the lower cervical spine.

Traumatic rotatory displacement (TRD) are defined as all slight anterior corporeal displacements (less than 1/3 of the vertebral body) secondary to different vectors, but with a constant and dominant rotatory component. The authors report on 47 cases of TRD (35% of all severe lower cervical spine injuries) (follow-up: 6 months to 7 years). TRD occurs only when two lesions are present: an anterior lesion in the disk and ligaments, and a posterior lesion of the articular process, as the authors confirmed earlier in an experimental study on monkeys and specimens. Depending on the nature of the posterior lesions, three anatomoclinical types occur: 1) posterior capsular lesions cause unilateral facet dislocation (UFD): ten cases; 2) bony lesions of the articular process cause unilateral facet fracture (UFF): 28 cases; 3) double bony lesions, which can set free the articular facets, are called fracture separation of the articular pillar (FSAP): nine cases. The common radiographic characteristic of these three lesions is slight anterior displacement (or antero-listhesis), which is well seen on the lateral film; only tomograms or CT scans can show the posterior lesions. Instability, as defined by Roy-Camille, Denis and our experiments, was obvious on X-rays: soon after the injury, for UFD, and some time later, for 18 UFF and three FSAP. Statistically, 25% of all cases of TRD are associated with another traumatic lesion of the lower or upper cervical spine. Clinically, there is a 30% rate of radicular complications in TRD: this figure is higher than that of other injury types.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1988

[Kinetics of pefloxacin diffusion in human bone tissue following a single infusion of 800 mg. Evaluation of an extraction technic using chloroform].

A better understanding of the pharmacokinetics of pefloxacin in human bone is warranted by the efficacy of this drug in the treatment of bone and joint infections. Surgical bone samples were taken at 30 mn, 1h, 6h, 12h and 24 h after the administration of a single 800 mg intravenous dose of pefloxacin over 1 hour for 26 patients who underwent surgery in an orthopedic surgery ward. Drug concentration was measured by a microbiological method (extraction of the antibiotic in buffer or with chloroform). Up until the 24th hour, in 25/26 cases, the bone levels were superior to 2 mg/l (the critical concentration of pefloxacin) in cortical as well as in spongy bone. Our study reveals a good diffusion of pefloxacin in bone, results which support the idea that this antibiotic may be prophylactically effective in orthopedic surgery.

Bone and Bones↗
PubMed1985

Distal radioulnar involvement in trauma of the wrist.

The distal radioulnar joint is the weakest point of the rotational column of the wrist. This joint is a functional part of the radiocarpal joint, united to it by an elastic tightening system, and perfectly controlled by the ulnaris (especially the extensor carpi) tendons. Our anatomic study allowed to define the mechanisms of the lesions and the methods for their correction. The key to success seems to be a functionally dynamic extensor carpi ulnaris and its dorsal position in supination. Our clinical study shows that all injuries to the distal radioulnar joint associated with trauma of the wrist or of the forearm are a factor of severity and they may be responsible for the high rate of complications. Therefore, in Galeazzi's fracture-dislocation, a specific method of stabilization may need to be associated with the radius osteosynthesis. In the absence of degenerative changes, chronic instability of the distal radioulnar joint can benefit from ligament stabilization. Results so far have been very encouraging, as far as young patients are concerned. Complex injuries remain a major obstacle, in which ligamentous and bone lesions must be distinguished by confronting clinical observation with paraclinical investigations. Computerized tomography seems to be of limited value, although this method of investigation is still in its prospective stages. Concerning management, shortening of the ulna with dorsal repositioning of the extensor carpi ulnaris allows to decompress the carpo-ulnar compartment, to stretch the tendinous and ligamentous structures, and, if need, to restore radioulnar congruity. Better knowledge of this pathology will allow to categorize radioulnar tears associated with wrist injuries. Under emergency conditions, surgical or non operative management must be adapted, allowing healing to occur with perfect restoration of the distal epiphysis of the radius. By doing so good functional results may be guaranteed.

Fracture Fixation, Internal↗
PubMed1984

[Bone levels of dibekacin].

Levels of an aminoglycoside, dibekacin, are studied in bone. Fifteen specimens were obtained by Tanzer trocar biopsy three hours after the ninth injection of dibekacin (1 mg/kg). Separation of cortical and spongy bone was not feasible owing to the small weight of specimens. Dibekacin concentrations were determined by microbiological assay. These concentrations were evaluated using a reference range in bone tissue determined with the same method and must be corrected according to blood levels. Dibekacin levels were 0.22 +/- 0.10 mg/l in healthy, non- contaminated specimens, and 1.70 and 1.80 mg/l in infected bone tissue.

Bacterial Infections↗