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Biomedical subjects

C Andrew

Publications and source records attributed to C Andrew.

At least 19 recordsLinked to original sources
PubMed1999

Lack of bilateral coherence of post-movement central beta oscillations in the human electroencephalogram.

Voluntary finger movement results in attenuation or desynchronization of the Rolandic mu and central beta rhythms some seconds before movement, followed by a post-movement synchronization of the central beta activity (post-movement beta synchronization). Although it has been demonstrated that the Rolandic mu rhythms show a lack of bilateral coherence, the coherence between post-movement central beta oscillations over left and right hemispheres has, as yet, not been investigated. In this study, post-movement changes in central beta activity over left and right sensorimotor hand areas are investigated in 13 healthy subjects by calculation of event-related coherence (ERCoh). The ERCoh time course allows the investigation of linear phase-coupling before, during and after voluntary movement. It is shown that no interhemispheric coherence exists between post-movement beta oscillations.

Aged↗
PubMed1999

Cerebral correlates of preserved cognitive skills in autism: a functional MRI study of embedded figures task performance.

When considering the cognitive abilities of people with autism, the majority of studies have explored domains in which there are deficits. However, on tests of local processing and visual search, exemplified by the Embedded Figures Task (EFT), people with autism have been reported to demonstrate superiority over normal controls. This study employed functional MRI of subjects during the performance of the EFT to test the hypothesis that normal subjects and a group with autism would activate different brain regions and that differences in the patterns of these regional activations would support distinct models of cerebral processing underlying EFT performance in the two groups. It was found that several cerebral regions were similarly activated in the two groups. However, normal controls, as well as demonstrating generally more extensive task-related activations, additionally activated prefrontal cortical areas that were not recruited in the group with autism. Conversely, subjects with autism demonstrated greater activation of ventral occipitotemporal regions. These differences in functional anatomy suggest that the cognitive strategies adopted by the two groups are different: the normal strategy invokes a greater contribution from working memory systems while the autistic group strategy depends to an abnormally large extent on visual systems for object feature analysis. This interpretation is discussed in relation to a model of autism which proposes a predisposition towards local rather than global modes of information processing.

Adult↗
PubMed1998

Neural responses to facial and vocal expressions of fear and disgust.

Neuropsychological studies report more impaired responses to facial expressions of fear than disgust in people with amygdala lesions, and vice versa in people with Huntington's disease. Experiments using functional magnetic resonance imaging (fMRI) have confirmed the role of the amygdala in the response to fearful faces and have implicated the anterior insula in the response to facial expressions of disgust. We used fMRI to extend these studies to the perception of fear and disgust from both facial and vocal expressions. Consistent with neuropsychological findings, both types of fearful stimuli activated the amygdala. Facial expressions of disgust activated the anterior insula and the caudate-putamen; vocal expressions of disgust did not significantly activate either of these regions. All four types of stimuli activated the superior temporal gyrus. Our findings therefore (i) support the differential localization of the neural substrates of fear and disgust; (ii) confirm the involvement of the amygdala in the emotion of fear, whether evoked by facial or vocal expressions; (iii) confirm the involvement of the anterior insula and the striatum in reactions to facial expressions of disgust; and (iv) suggest a possible general role for the perception of emotional expressions for the superior temporal gyrus.

Adult↗
PubMed1998

Investigation of facial recognition memory and happy and sad facial expression perception: an fMRI study.

We investigated facial recognition memory (for previously unfamiliar faces) and facial expression perception with functional magnetic resonance imaging (fMRI). Eight healthy, right-handed volunteers participated. For the facial recognition task, subjects made a decision as to the familiarity of each of 50 faces (25 previously viewed; 25 novel). We detected signal increase in the right middle temporal gyrus and left prefrontal cortex during presentation of familiar faces, and in several brain regions, including bilateral posterior cingulate gyri, bilateral insulae and right middle occipital cortex during presentation of unfamiliar faces. Standard facial expressions of emotion were used as stimuli in two further tasks of facial expression perception. In the first task, subjects were presented with alternating happy and neutral faces; in the second task, subjects were presented with alternating sad and neutral faces. During presentation of happy facial expressions, we detected a signal increase predominantly in the left anterior cingulate gyrus, bilateral posterior cingulate gyri, medial frontal cortex and right supramarginal gyrus, brain regions previously implicated in visuospatial and emotion processing tasks. No brain regions showed increased signal intensity during presentation of sad facial expressions. These results provide evidence for a distinction between the neural correlates of facial recognition memory and perception of facial expression but, whilst highlighting the role of limbic structures in perception of happy facial expressions, do not allow the mapping of a distinct neural substrate for perception of sad facial expressions.

Adult↗
PubMed1998

Do changes in coherence always reflect changes in functional coupling?

It is well known that the rhythmic activity within the alpha band in the central area may be composed of two different types of rhythms: (i) the Rolandic mu rhythm, representing the intrinsic activity of the sensorimotor area, and (ii) rhythmic activity believed to be generated within parieto-occipital areas and to extend into central regions through volume conduction (the 'classical alpha rhythm'). In this paper we clearly demonstrate that this second type of rhythmic activity is not due to volume conduction from parieto-occipital areas. We also demonstrate the significant impact of the coexistence of these two types of rhythms on the interpretation of interhemispheric coherence measurements.

Alpha Rhythm↗
PubMed1998

Prefrontal involvement in "temporal bridging" and timing movement.

Brain activity exclusively related to a temporal delay has rarely been investigated using modern brain imaging. In this study we exploited the temporal resolution of functional magnetic resonance imaging (fMRI) to characterise, by sinusoidal regression analysis, differential neuroactivation patterns induced in healthy subjects by two sensorimotor synchronization tasks different in their premovement delay of either 0.6 s or 5 s. The short event rate condition required rhythmic tapping, while the long event rate condition required timing of intermittent movements. Left rostral prefrontal cortex, medial frontal cortex, SMA and supramarginal gyrus demonstrated increased MR signal intensity during low frequency synchronization, suggesting that these brain regions form a distributed neural network for cognitive time management processes, such as time estimation and motor output timing. Medial frontal cortex showed a biphasic pattern of response during both synchronization conditions, presumably reflecting frequency-independent motor output related attention. As predicted, sensorimotor and visual association areas demonstrated increased MR signal intensity during high frequency synchronization.

Adult↗
PubMed1998

The trophic effects of purines and purinergic signaling in pathologic reactions of astrocytes.

This article reviews the effects of extracellular purine bases, nucleosides, and nucleotides as intracellular signaling molecules with trophic effects on cells after insults to the brain and spinal cord. Astrocytes are the principal source of extracellular purines in brain after injury, ischemia, or trauma. In vitro and in vivo extracellular purines have both immediate and long-term trophic effects, including stimulation of astrocyte and neuronal differentiation, mitosis, morphogenesis, apoptosis, and stimulation of growth and trophic factor synthesis. The effects of the nucleoside adenosine and the nucleotide adenosine triphosphate (ATP) are mediated principally via specific receptors on the cell surface coupled to a series of signaling cascades. Unlike adenosine and ATP, guanosine and guanosine triphosphate (GTP) do not act at classical purine receptors. However, they exert similar effects on astrocytes, apparently by causing the astrocytes to release large amounts of adenosine and ATP over prolonged periods. The release of adenosine and ATP may be related to the effects of guanosine on the purine nucleoside transporters in the cell membrane, whereas the release of ATP may be due to the effects of GTP on the ATP-binding cassette (ABC) proteins. Physiologically, the effects of guanosine are important because this nucleoside, unlike adenosine, remains elevated for prolonged periods after brain injury.

Adenosine↗
PubMed1997

A specific neural substrate for perceiving facial expressions of disgust.

Recognition of facial expressions is critical to our appreciation of the social and physical environment, with separate emotions having distinct facial expressions. Perception of fearful facial expressions has been extensively studied, appearing to depend upon the amygdala. Disgust-literally 'bad taste'-is another important emotion, with a distinct evolutionary history, and is conveyed by a characteristic facial expression. We have used functional magnetic resonance imaging (fMRI) to examine the neural substrate for perceiving disgust expressions. Normal volunteers were presented with faces showing mild or strong disgust or fear. Cerebral activation in response to these stimuli was contrasted with that for neutral faces. Results for fear generally confirmed previous positron emission tomography findings of amygdala involvement. Both strong and mild expressions of disgust activated anterior insular cortex but not the amygdala; strong disgust also activated structures linked to a limbic cortico-striatal-thalamic circuit. The anterior insula is known to be involved in responses to offensive tastes. The neural response to facial expressions of disgust in others is thus closely related to appraisal of distasteful stimuli.

Adult↗
PubMed1997

On the existence of different alpha band rhythms in the hand area of man.

Earlier investigations have reported that the Rolandic mu rhythm and the parieto-occipital alpha rhythm, the latter thought to be volume-conducted into central areas, both contribute to scalp-recorded electroencephalogram (EEG) in the central region of humans. The present study applies dynamic cross-spectral analysis to event-related EEG data recorded during finger movement. In 10 of 12 subjects, a superposition of Rolandic mu rhythms and bilaterally coherent alpha band rhythms is found in the central area; however, the use of closely-spaced Laplacian derivations rules out volume-conduction effects, providing evidence that both rhythms are generated in the underlying neocortical circuitry. An explanation for the coexistence of these rhythms in terms of a global/local EEG model is provided.

Alpha Rhythm↗
PubMed1997

Foot and hand area mu rhythms.

Spontaneous EEG can display spatio-temporal patterns of desynchronized or synchronized alpha band activity. Event-related desynchronization (ERD) of rhythms within alpha and lower beta bands is characteristic of activated cortical areas ready to process information or to prepare a movement, while event-related synchronization (ERS) in the same frequency bands can be seen as an electrophysiological correlate of resting or idling cortical areas. EEG was investigated over primary sensorimotor and premotor areas during discrete hand and foot movements. ERD was found over the primary hand area during finger movement and over the primary foot area during toe movement. The former was observed in every subject, the latter was more difficult to find. From these results it can be speculated that each primary sensorimotor area has its own intrinsic rhythm, which becomes desynchronized when the corresponding area is activated. ERS, in the form of an enhanced mu rhythm on electrodes overlying the primary hand area, was observed not only during visual processing but also during foot movement. In both cases, the hand area is not needed to perform a task and, therefore, can be considered to be in an idling state. The supplementary motor area (SMA) also plays an important role in preparation and planning of movement. It is demonstrated that this area also displays rhythmic activity within the alpha band, that is both linearly and non-linearly phase coupled to the intrinsic (mu) rhythm of the primary hand area. With planning and preparation of movement, this SMA rhythm is desynchronized and also the degree of coupling between the two areas decreases.

Electroencephalography↗
PubMed1997

Dynamic multi-planar EPI of the urinary bladder during voiding with simultaneous detrusor pressure measurement.

Magnetic resonance imaging gives high quality images of the urinary bladder with excellent contrast. We report here the first application of dynamic, multi-slice, echo planar imaging to a study of urinary bladder emptying. Changes in urinary bladder volumes and rates of urine expulsion from the bladder have been measured simultaneously with bladder pressure. The method shows promise for clinical applications involving compromised bladder function, for reappraising bladder contraction strength-volume relationships, and for investigating the rate of change of length, three-dimensional shape, and wall tension in different parts of the bladder during micturition.

Echo-Planar Imaging↗
PubMed1997

Functional MR imaging during odor stimulation: preliminary data.

PURPOSE: To determine the locations and extent of activation in areas of the brain at functional magnetic resonance (MR) imaging with olfactory stimulation and to determine whether accommodation or amplification of brain activation occurs with sequential olfactory stimulation. MATERIALS AND METHODS: Five adult men with normal senses of smell underwent multisection, gradient-echo, echo-planar imaging according to a blood-oxygen-level-dependent experimental paradigm. Odorants that nearly exclusively stimulate the olfactory system and odorants that stimulate the olfactory and trigeminal nerves were compared by using repetitive imaging procedures. RESULTS: Activation with olfactory nerve-mediated odorants was demonstrated in the orbitofrontal cortex (Brodmann area 11) with a right-sided predominance. Mild cerebellar stimulation was also observed. With repeated testing, overall activation with olfactory nerve-mediated odorants declined. Odorants that also stimulated the trigeminal nerve produced additional cingulate, temporal, cerebellar, and occipital activation. Activation with combined trigeminal and olfactory system odors increased more than sixfold with repeated testing. CONCLUSION: Olfactory nerve-mediated and combined olfactory and trigeminal nerve-mediated odorants activate different regions of the brain. Orbitofrontal stimulation spreads to all parts of the brain when a trigeminal component is added. Habituation (deactivation) occurs with repeated testing of olfactory nerve-mediated odorants, while, paradoxically, activation increases with repeated exposure to odors that also stimulate the trigeminal nerve.

Adult↗
PubMed1996

Auditory hallucinations inhibit exogenous activation of auditory association cortex.

Percepts unaccompanied by a veridical stimulus, such as hallucinations, provide an opportunity for mapping the neural correlates of conscious perception. Functional magnetic resonance imaging (fMRI) can reveal localized changes in blood oxygenation in response to actual as well as imagined sensory stimulation. The safe repeatability of fMRI enabled us to study a patient with schizophrenia while he was experiencing auditory hallucinations and when hallucination-free (with supporting data from a second case). Cortical activation was measured in response to periodic exogenous auditory and visual stimulations using time series regression analysis. Functional brain images were obtained in each hallucination condition both while the patient was on and off antipsychotic drugs. The response of the temporal cortex to exogenous auditory stimulation (speech) was markedly reduced when the patient was experiencing hallucinating voices addressing him, regardless of medication. Visual cortical activation (to flashing lights) remained normal over four scans. From the results of this study and previous work on visual hallucinations we conclude that hallucinations coincide with maximal activation of the sensory and association cortex, specific to the modality of the experience.

Acoustic Stimulation↗
PubMed1996

Dependence of coherence measurements on EEG derivation type.

The impact is reported of different EEG derivation types on short-term changes in the inter-hemispheric coherence between the left and right sensorimotor areas, during the planning and execution of right index finger movements. Data are recorded during an event-related paradigm in which cued index finger movements are made: Event-related coherence analysis is then applied to the monopolar (nose reference) data, as well as different reference-independent derivations such as bipolar, local average reference and source derivation. The results show that inter-hemispheric coherence between sensorimotor areas is dependent on the EEG derivation type. An increase in coherence during movement is found with nose reference and bipolar data, whereas for local average reference and source derivations, low inter-hemispheric coherence is observed, with no change in the coherence during movement. It is concluded that the coherence increase seen with nose reference data is due to an indirect effect of mu rhythm desynchronisation, rather than any increase in synchrony of the mu rhythms themselves. Local average reference and source derivations better reflect the activity of the underlying cortical structures (the mu generating networks), and coherence analysis using these derivations shows that the mu rhythms of left and right hemispheres are not coherent.

Electroencephalography↗
PubMed1996

Event-related coherence as a tool for studying dynamic interaction of brain regions.

This paper demonstrates a simple approach to calculating time courses of coherence for data recorded during an event-related paradigm. Event-related coherence (ERCoh) was investigated between left and right sensorimotor areas, and between contralateral sensorimotor and SMA during discrete right index finger movements. It is demonstrated that ERCoh can provide information regarding the dynamic interaction of spatially separated brain regions. In the upper alpha band, the mu rhythm of the contralateral sensorimotor area is shown to be linearly phase-coupled to rhythmic activity recorded over the SMA. This synchrony between the rhythms decreases during planning and execution of movement when the respective areas become active. In the gamma band, a short-lasting increase in coherence is found between the contralateral sensorimotor area and the SMA prior to movement, indicating possible functional interaction of these areas during the final stages of movement preparation.

Electrodes↗
PubMed1995

Neural correlates of working memory in a visual letter monitoring task: an fMRI study.

Complex mental operations rely on the coordinated activity of widely distributed brain regions constituting neurocognitive networks. Using multislice echoplanar functional magnetic resonance imaging (fMRI) we have contrasted regional brain activity during a control and an experimental condition which differed with respect to the demands placed on verbal working memory. Subjects were seven right-handed healthy male volunteers. Analysis of group and individual data revealed activation in the anterior and posterior parasagittal cortex in all subjects, left parietal cortex (six subjects) and left dorsolateral prefontal cortex (five subjects). These results suggest that verbal working memory is subserved by a neurocognitive network comprising cortical regions involved in attention, executive function and short term mnemonic processes.

Adult↗