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Biomedical subjects

C Anderson

Publications and source records attributed to C Anderson.

At least 415 records · Page 23Linked to original sources
PubMed1991

Angioscopy.

Improved technology has made the technique of video angioscopy available. This technique, when routinely applied, can provide a wealth of important information to the vascular surgeon. The long term benefits will include improvement of surgical techniques and the potential to simplify and lower the cost of vascular surgery. The angioscope has emerged as a potentially powerful tool for today's vascular surgical team. Nurses need to be aware of this procedure so that they can provide quality care for these patients.

Blood Vessels↗
PubMed1991

Noninvasive evaluation of cerebral ischemia. Trends for the 1990s.

A number of diagnostic tools have been developed over the past decade that facilitate the noninvasive evaluation of cerebral ischemia. From duplex Doppler ultrasound to xenon computed tomography and magnetic resonance angiography, a greater trend toward combining both anatomic and function information is anticipated. The methodology, limitations, and current clinical applications of these three diverse techniques, with emphasis on xenon computed tomography and magnetic resonance angiography, are discussed. Both xenon computed tomography and magnetic resonance angiography can be performed on current systems with minimal hardware and software modifications. As a result, standard anatomic and structural imaging can be supplemented with diverse information such as quantitative brain perfusion without and with flow challenging as well as flow mapping and velocity imaging, which approximates conventional x-ray angiography.

Brain↗
PubMed1991

Pharmacokinetics of percutaneous estradiol: a crossover study using a gel and a transdermal system in comparison with oral micronized estradiol.

The pharmacokinetics of three transdermal estradiol (E2) replacement regimens were studied following establishment of steady-state dynamics. Oestrogel 3.0 mg, Oestrogel 1.5 mg, and Estraderm transdermal delivery system 4 mg (0.05 mg/day) were administered for 14 days each to 15 postmenopausal volunteers, with a 14-day washout period between each regimen. The percutaneous E2 pharmacokinetics were compared with an oral micronized E2 preparation. Venous samples were obtained at 0, 1, 2, 4, 8, 12, and 24 hours on 3 sequential days 11 days after initial application of the Oestrogel and the transdermal delivery system, and at the same times after oral E2 ingestion. All three percutaneous regimens provided nearly constant serum E2 and estrone (E1) levels throughout their use. The mean serum E2 levels were 102.9 +/- 39.9, 68.1 +/- 27.4, and 41.1 +/- 13.5 pg/mL for Oestrogel 3.0 mg, Oestrogel 1.5 mg, and Estraderm, respectively. Oral E2 resulted in a mean serum E2 level of 114.0 +/- 65.2 pg/mL with marked peak and nadir values. The E1/E2 ratio was comparable with all three percutaneous regimens (1.08-1.33) and was significantly lower than that found with oral Estrace (5.05).

Administration, Cutaneous↗
PubMed1991

Dysplasia of oral mucosa: a unified approach to proper evaluation.

The histologic features of fully developed epithelial dysplasia of oral mucosa are readily recognized. Early dysplastic change, however, may present a diagnostic challenge since its frequently subtle features may, on occasion, cause it to be overlooked and thus undercalled. The problem of underdiagnosis is further compounded in many instances by the markedly diverse manner in which altered surface epithelium is described, interpreted, and reported. In an effort to establish a more unified manner of histopathologic interpretation of oral epithelial tissue, we propose clear definitions for the terms atypia, dyskeratosis, dysplasia, and lichenoid, underscoring topographic as well as morphological criteria for each. Significant alterations in rete ridge architecture and maturation disturbance are identified as subtle yet important markers of dysplastic potential, even in the absence of atypical cytomorphology. Correlation of clinical and historical data with microscopic findings is also stressed as an important adjunct to the arousal of diagnostic suspicion. Interpretative rationale and an illustrative case are offered in support of points raised.

Humans↗