Search PubMed⌕ Search

Biomedical subjects

C Amiel-Tison

Publications and source records attributed to C Amiel-Tison.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Arterial hypertension during pregnancy. 531 cases treated in one centre (author's transl)].

Between 1977 and 1979, 531 consecutive cases of hypertension complicating pregnancy were observed at the Maternité de Port-Royal, Paris. All patients were treated preferentially with methyldopa, and most women with moderate hypertension were treated as out-patients. Perinatal mortality in these hypertensive women was the same as for normotensive women who delivered at the Maternité and for the French population as a whole during the same period.

Female↗
PubMed1982

A new neurologic and adaptive capacity scoring system for evaluating obstetric medications in full-term newborns.

A variety of examinations are currently available for evaluating the neurobehavior of the newborn. These exams are often difficult and time-consuming to perform, require extensive training of the examiners, and produce results that may be difficult to interpret. The authors describe a new Neurologic and Adaptive Capacity Score (NACS) for full-term neonates and compare it with the Scanlon Early Neonatal Neurobehavioral Scale (ENNS), the most widely used test for evaluating effects of obstetric medication on the neonate. The NACS was designed as a screening test to detect central nervous system depression from drugs and also to differentiate these effects from those found after birth trauma and perinatal asphyxia. The NACS is based on 20 criteria, each of which is given a score of 0, 1, or 2. These criteria assess five general areas: 1) adaptive capacity; 2) passive tone; 3) active tone; 4) primary reflexes; and 5) alertness, crying, and motor activity (general observations). In contrast to the ENNS, the NACS places more emphasis on motor tone, avoids the use of noxious stimuli (pinprick, repeated Moro examinations), takes half the time to perform, and provides for any given baby a single number that immediately identifies a depressed or vigorous neonate.

Adaptation, Physiological↗
PubMed1981

Neonatal effects of maternal administration of acebutolol.

Systolic blood pressure, heart rate, and blood glucose concentration were measured in the first three days of life in 10 infants born to mothers who had received acebutolol, a cardioselective beta-adrenergic-blocking agent, for hypertension in pregnancy and compared with values in 10 infants whose mothers had received methyldopa. The blood pressure was expressed as a percentage of the expected value. Blood pressure was significantly lower in the infants of the mothers given acebutolol (p less than 0.02, less than 0.01, and less than 0.01 respectively during the three days of observation). Heart rate was also lower, but the significance was only at the 0.05 level. Blood glucose was not significantly different between the two groups. These results suggest that care should be taken in prescribing beta-adrenergic-blocking drugs during pregnancy.

Acebutolol↗
PubMed1981

Incidence of idiopathic respiratory distress syndrome during the last ten years.

In the Port Royal Maternity Hospital, with about 2000 deliveries per year, the incidence of idiopathic respiratory distress syndrome (IRDS) has been studied during the last ten years. Because of the potential hazards of drugs, the attitude of restricting the use of steroids to a few particular cases was adopted. In period I (1968-1969), the incidence of IRDS was 1 per 100 live births. In period II (1972-73), the incidence dropped to 0.54% of the live births. In period III (1975-77), the incidence remained at 0.47% of the live births. The difference in frequency between period I and period II and III is statistically significant (P less than 0.01). This diminution appears to be the result of an overall improvement in the pre- and postnatal care of premature infants. The newborns who could have benefited from prenatal glucocorticoid treatment are studied in period III. From 28 to 34 wk of gestational age, 148 infants were born. Seventy-eight (not equal to 50%) did not have any respiratory problems, 54 had mild and transitory distress and 16 (not equal to 10%) had IRDS. In only 7 cases was the time interval between the first signs of premature labor and delivery longer than 24 h. In conclusion, at least 148 neonates would have had prenatal glucocorticoid treatment, in order possibly to avoid 7 cases of IRDS, which would mean hazard for 20 and benefit for 1. A hazardous effect on brain development seems to be the main concern and has to be more fully documented.

Female↗
PubMed1981

[Neonatal mortality and morbidity. Priorities in perinatal care (author's transl)].

Perinatal mortality rates have been decreasing from 25 to 15 0/00 at the Port-Royal maternity hospital from 1969 to 1978. The incidence of materno-foetal infection has been stable within the last 10 years, around 1.2% live-births; mortality linked with these infections represents 28% of early neonatal deaths and remains nearly as high as mortality from malformations. The incidence of Idiopathic Respiratory Distress Syndrome has been decreasing as low as 0.3% live births (14% between 28 and 34 weeks of gestation). The risk appears not high enough to justify the systematic use of prenatal glucocorticoids. Birth injury in the full term newborn occurs at a rate of 1 0/00 births in the most severe cases. In cases of moderate severity, the incidence has been decreasing from 1% to 1 0/00 births within the last 5 years, probably due to improved obstetrical care.

Female↗
PubMed1980

Possible acceleration of neurological maturation following high-risk pregnancy.

Evidence of an advance on neurological maturation of 4 weeks or more was detected in 16 infants with gestational ages between 30 and 37 weeks. These infants were all from pregnancies in which it is fair to conclude that one form or another of intrauterine stress was in operation. The hypothesis is advanced that unfavorable intrauterine conditions can induce an acceleration of neurologic development.

Female↗
PubMed1980

[Incidence of birth injury in full term newborns in the last 5 years at Port Royal Maternity Hospital (author's transl)].

The incidence of birth injury in full term neonates during the last 5 years at Port Royal Maternity Hospital has been determined. Cerebral symptoms were classified in three grades; mild, moderate and severe. The study was concerned with gestational and obstetric causes of cerebral damage. Babies with malformations, metabolic disorders and infections were excluded. During the study the incidence of intra-partum deaths and still births was low, 2 to 2.5 per thousand births, and did not alter but there was a statistically significant reduction in the number of babies in the moderate and mildly affected groups. This may be due to improved obstetric practice. From 1974 to 1978 the incidence of fetal heart monitoring increased from 20 to 60 percent and since early 1977 amnioscopy has been performed in every woman admitted. The incidence of cerebral symptoms may be an important method of assessing the quality of obstetric care. Serious accidents are becoming rare and therefore the incidence of mild or moderate cerebral symptoms is likely to be a better indicator of good obstetric care. In full term infants perinatal factors are infrequently the cause of brain damage.

Birth Injuries↗
PubMed1978

The lecithin/sphingomyelin ratio in 132 insulin-dependent diabetic pregnancies.

A total of 228 determinations of L/S ratios were performed in 132 insulin-dependent diabetic pregnancies. A declining L/S ratio was observed in 6 per cent of the cases without adverse effects on the fetus. No significant difference in the percentage of mature L/S ratios by weeks of pregnancy was found in the different classes of diabetes. An immature L/S ratio was associated with a significant increase of low Apgar scores. At each stage of pregnancy, there was no significant difference in the percentage of mature L/S ratios according to the sex of the baby nor according to the presence or absence of polyhydramnios. Among the five infants with HMD two had a mature L/S ratio within 2 days of birth. This represents 3 per cent incidence of false-positive results. Despite this finding, we feel that the determination of L/S ratio is a useful advance in the management of diabetic pregnancies.

Amniotic Fluid↗
PubMed1978

A method for neurological evaluation within the first year of life: experience with full-term newborn infants with birth injury.

In a prospective study undertaken at Port-Royal Maternity Hospital, Paris, 1785 deliveries were studied during a 15-month period. Signs of cerebral dysfunction were observed in 57 newborn infants--mild signs in 38 infants, moderate in 17, severe in 2. There was a high incidence of abnormal labour in 28 of these 57 infants (50%) (dysfunctional labour patterns without obvious cephalopelvic disproportion, including false labour, prolonged active-phase dilatation, (prolonged descent, marked caput succedaneum). During the first year of life, 30 of the 57 infants were followed. In 14 of the 30 infants transitory abnormalities were observed. In five infants abnormalities persisted at the end of the first year. Eleven infants were normal throughout the first year. In another study the incidence of cerebral symptoms at birth was compared in full-term infants born in 1974 and those born in 1976. Thirteen infants with moderate and severe symptoms were observed out of 1578 deliveries during 1974 and five out of 1934 deliveries during 1976, the incidence of Caesarean section necessitated by acute fetal distress being the same in both groups. This decreasing percentage of complications appears to be linked with improving care, including more widespread use of fetal monitoring.

Birth Injuries↗