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Biomedical subjects

C Almange

Publications and source records attributed to C Almange.

72 records · Page 4Linked to original sources
PubMed1975

[T.R.H. test in 93 cases of thyroid disease].

The authors used the stimulation of TSH test by intravenous injection of TRH in 93 patients. They obtained a negative or weak response in thyrotoxicosis, toxic adenomas, and Means syndrome, and a normal response with non-extinctive hot nodules. The response was positive and high in primary hypothyroidism. The results are sometimes paradoxal in hypothalamo-pituitary pathology even after hypophysectomy: a delayed and elevated response is in favour of a pituitary reserve of non-utilised TSH. In non-functional goitres and thyroiditis, the sometimes positive responses obtained are an indication for substitutive and depressive therapy.

Adenoma↗
PubMedDate not supplied

Prenatal diagnosis of familial tuberous sclerosis following detection of cardiac rhabdomyoma by ultrasound.

The authors report a case of tuberous sclerosis (TS), diagnosed by prenatal ultrasound, which was suspected by the detection of intracardiac tumours and confirmed by the family investigation. Cardiac rhabdomyomata can be visualized early on echography and must suggest this diagnosis. The place of genetic counselling and prenatal diagnosis in TS is examined.

Echocardiography↗
PubMedDate not supplied

[Complete atrio-ventricular block caused by a metastatic tumor of the heart. Apropos of a case].

Metastatic tumors of the heart are often asymptomatic but they may dominate the clinical picture. The location in the interventricular septum can account for conduction disturbances. The authors report a case of esophagus neoplasm with septal metastasis responsible for a complete atrioventricular block. The histologic study of the bundle of His by serial sections showing the destruction of the conduction fibres by malignant elements has not been carried out till now except in some observations. The prognostic of the atrioventricular metastatic block is very poor; the ten months' survival which was observed in the reported case is one of the most extended in literature.

Bundle of His↗
PubMedDate not supplied

[Hyperthyroidism and atrioventricular heart block (author's transl)].

Two cases of thyrotoxicosis including a first-degree heart block are reported; a study of action potentials of the bundle of His was achieved in the second case. The association atrioventricular block-hyperthyroidism is unusual but does not seem to be a pure coincidence. The direct effect of thyroid hormon on the myocardium is supposed to be responsible for the conduction disturbance; its disappearance with the cure of the thyrotoxicosis is a favourable argument for a relation of causality. The therapeutic consequence of this association is to exclude completely the use of betablockers.

Action Potentials↗
PubMedDate not supplied

[Williams-Beuren syndrome and renovascular arterial hypertension].

The Williams and Beuren's syndrome associates a particuliar facies, a mental debility, a supravalvular aortic stenosis, and frequent vascular anomalies of pulmonary artery as well as aorta and its branches. Relations between this syndrome and congenital idiopathic hypercalcemia seem now determined; the hypertension which has been frequently observed in this last case, seems more unusual in the case of Williams and Beuren's syndrome. The authors report a case about this syndrome in which the hypertension seemed linked to a stenosis of the left renal artery and which has been treated surgically. A year later the result is satisfactory but the evolutive potential of arterial lesions described in this syndrome does not necessory lead to a final recovery. Besides there are in this disease hypertensions which are relevant to an other etiology (more especially aortic hypoplasia) and stenosis of renal arteries without hypertension.

Adolescent↗
PubMedDate not supplied

[Horseshoe kidney and hypertension (author's transl)].

The authors report a case of horseshoe kidney responsible for hypertension through a one-sided renal dysplasia. The part of the renal malformation in the development of the hypertension is attested by the activities of renin from renal veins, by the isotopic nephrogram and by the disappearance of the hypertension following the heminephrectomy. The hypertension seems an exceptionnal complication of the horseshoe kidney, which can be surprising given the frequency of this malformation and associated urologic anomalies.

Adult↗
PubMedDate not supplied

[Glomerular disease associated with myelofibrosis (author's transl)].

The authors report the case of a 46 year-old patient presenting with membranous-proliferative glomerular disease, megakaryocytes present in the glomerular capillaries, evolving concomitantly with myelofibrosis. There are two possible explanations for this unusual association: the glomerular disease and the myelofibrosis may both result from the same etiologic and pathogenic factor, or the glomerular disease may be the consequence, thrombocytosis existing, of platelet activation, either direct or after deposition of immune complexes. The formation of immune complexes after antigenic stimulation in myelofibrosis is theoretically compatible with immunitary anomalies found in the evolution of this disorder as described in the literature.

Humans↗
PubMedDate not supplied

[Renal lesions in myelofibrosis (author's transl)].

In 26 cases of myelofibrosis, the authors investigated for possible renal impairment that can be appraised from the usual clinical, laboratory, and roentgenographic signs. No anomalies were demonstrated in 12 of these cases. In 14 (or 53%) of the patients, some anomaly was discovered : essentially proteinuria with minor alteration of renal function, but also, two cases of poorly functioning left kidney evidenced on intravenous urograms, one case of acute anuric renal failure connected with hyperuricemia, one case of hypokalemic tubulo-interstitial nephritis, and one case of glomerulonephritis with, nephrotic syndrome. This study, when compared to the literature, indicates that besides nephropathy specific to myelofibrosis and attributed to myeloid metaplasia in the kidney, serious consideration must be given to lesions due to (1) compression of the left kidney by the enlarged spleen, (2) urate precipitation in the urinary passages, and (3) a possible glomerular disorder whose mechanism remains undefined.

Adult↗
PubMedDate not supplied

[Orthostatic hypotension and obstructive hypertrophic cardiomyopathy (author's transl)].

The authors relate two cases of idiopathic hypertrophic subaortic stenosis detected after orthostatic hypotension with syncope. This type of detection has not been described till now. Relations between idiopathic hypertrophic subaortic stenosis and orthostatic hypotension are debated as well as relation between IHSS and systemic hypertension which has existed previously in the two cases. It seems suitable to call up IHSS systematically before every orthostatic hypotension at least in elderly. Beta-blockers can in such cases considerably improve orthostatic symptoms.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[Hyperacute periarteritis nodosa complicating Basedow's disease].

The symptoms and the evolution of necrotizing vasculitis vary greatly. The authors illustrate the case of an 18 year old patient with a history of frequent allergic manifestations (urticaria and others) who was found to have, in septembre 1975, a typical case of Grave's disease. During the following 2 months she was treated with an iodide derivative. One year later the clinical signs increased to the point where a treatment associating lugol, carbamizole and propanolol was deemed necessary. Less than 2 months later there developed a polyvisceral disease with oscillating fever, polyarthralgia and necrotizing vasculitis. The plurivisceral nature of the illness was further illustrated by the presence of a hyperreflexia, a glomerulopathy and retinal exsudats. A muscle biopsy revealed the necrotizing vasculitis with granulomas typical of periarteritis nodosa. Cardiac, neurologic and renal complications were responsable for a rapid down-hill course and despite corticoïdes and immunosuppresive drugs, the patient died after a few weeks of treatment. That periarteritis nodosa should complicate the evolution of Grave's disease suggests a connection between the two, very probably immunologic in nature. The role of drugs capable of inducing vasculitis must be explored, especially the iodide derivatives, the antithyroïd medications or their association. Such cases, even though they may be rare, should incite special care in the prescription of antithyroïd drugs in the allergic patient.

Acute Disease↗
PubMedDate not supplied

[Ventricular arrhythmias in mitral valve prolapse (author's transl)].

Ventricular arrhythmias were looked for in 35 patients with mitral valve prolapse. Their frequency is estimated to 35% in the 31 cases studied prospectively. Ventricular tachycardia is observed in 23% of them. Two patients in emergency had to undergo an external electric shock, one of them for ventricular fibrillation. The interest of different methods of detection and investigation of arrhythmia is questioned. Ventricular ectopic depolarizations are usually detected in the first routine ECG when arrhythmia is severe, but the degree of arrhythmia is generally underestimated. The 24 hour electrocardiographic ambulatory monitoring appears as the choice method but it might be inefficient as shown in some observations. In the latter cases, the exercise testing appears as an indispensable complement for the evaluation and long term follow-up of ventricular arrhythmias in mitral valve prolapse.

Adolescent↗
PubMedDate not supplied

[Evaluation of cardiovascular disturbances in patients with erythrodermic skin diseases by echocardiography (author's transl)].

Echocardiography was performed in seventeen patients with acute or chronic erythrodermic skin disease, to assess the cardiovascular disturbances. Fundamental difference is between the acute erythrodermic skin diseases, in which the cardiac output is low and the chronic erythrodermic skin diseases in which the cardiac output is very high, during the attacks. The reasons of this difference are studied. The ventricular function parameters are always normal and the hemodynamic disturbances seem only to be related to the modifications of the cardiac output induced by the erythrodermic skin diseases.

Acute Disease↗
PubMedDate not supplied

[Echocardiographic evaluation of cardiovascular effects of the arteriovenous fistula in haemodialyzed patients (author's transl)].

A prospective echocardiographic study was conducted in 24 patients undergoing haemodialysis to evaluate the cardiovascular consequences of their arteriovenous fistula (AVF). Recordings were taken before and after occlusion of the AVF during 15 minutes, which made it possible to measure the output of the shunt. With one exception, the AVF had no effect on the mechanisms of cardiac failure and arterial hypertension. Echocardiography therefore seems capable of providing valuable information on the haemodynamics status of patients under haemodialysis.

Adult↗