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Biomedical subjects

C Allard

Publications and source records attributed to C Allard.

At least 55 records · Page 3Linked to original sources
PubMed1982

Serum high-density lipoprotein cholesterol in male and female Olympic athletes.

High-density lipoprotein cholesterol (HDLC) is negatively associated with the risk of cardiovascular disease, and high levels of HDLC have been reported for physically active people. During the 1976 Olympic Games, held in Montreal, Canada, several physiological variables were measured in volunteer male and female Olympic athletes, from whom blood was collected. To compare these elite athletes with the general population and other physically active groups, HDLC was measured in serum samples that were kept at -80 degrees C and after precipitation of lipoproteins of lower densities by heparin-manganese. High-density lipoprotein cholesterol levels were significantly higher in women (65.2 +/- 2.1 N = 31) than in men (54.5 +/- 1.4, N = 64) (P less than 0.01). Olympic athletes had approximately 20% more HDLC than levels reported in the literature for the general population of North America. Levels of HDLC of the male Olympic athletes were comparable to those reported for elite world-class runners of comparable age. No correlation was found between HDLC and Quetelet index or maximum oxygen consumption. Levels of HDLC in athletes 20-24 yr of age were lower than in the other age groups studied and was positively correlated with age for athletes over 20 yr of age. Although a causal relationship between physical activity and HDLC remains to be established unequivocally, the present findings agree with several other studies that link various levels of physical activity with blood concentrations of HDLC higher than those found in sedentary populations.

Adult↗
PubMed1982

Scanning electron microscopy of the spleen in a case of sickle cell anemia.

We report the case of a 5 1/2-year-old Congolese girl with homozygous sickle cell anemia and hereditary persistence of fetal hemoglobin (Hemoglobin S 88%, Hemoglobin A2 2%, Hemoglobin F 10%). She presented marked enlargement of the spleen, descending into the left iliac fossa and producing significant hypersplenism with thrombocytopenia as low as 60,000/mm3. Additional findings included an increase in plasma volume to 90% greater than normal, with elevation of both cardiac output (determined by radiolabelled albumin) to 4 l/min and cardiac index to 6.25 l/min. Splenectomy became clinically necessary after the occurrence of two successive episodes of acute splenic sequestration characterized by a rapid, painful splenic enlargement associated with a poorly tolerated fall in hemoglobin to 4 gm/dl. Preparation for surgery included exchange transfusion with slow removal of 20 ml/kg of the patient's blood and replacement with type specific HbAA blood at 15 ml/kg. Following the exchange transfusion, the hemoglobin level rose from 8 to 12 gms/dl and the percentage of hemoglobin S fell from 89% to 36%. The patient did well following splenectomy and 8 weeks later repeat hematologic values showed a hemoglobin of 10.1 gms/dl, reticulocytes of 500,000/mm3, platelet count of 254,000/mm3 and white count of 13,200/mm3.

Anemia, Sickle Cell↗
PubMed1981

Isoelectric focusing of red cell phosphoglucomutase (E.C.: 2.7.5.1) at the PGM1 locus in a French-Canadian population.

Phosphoglucomutase1 (PGM1) polymorphism was studied in a French-Canadian population of Québec city, Canada by means of a low voltage (max 500 V) isoelectric focusing (IEF) procedure on vertical polyacrylamide gel slabs. Frequencies of the four common PGM1 genes estimated from the phenotype distribution in 308 unrelated individuals were PGM1(1+), 0.61 (+/- 0.02); PGM1(1-), 0.13 (+/- 0.01); PGM1(2+), 0.18 (+/- 0.02); and PGM1(2-), 0.08 (+/- 0.01). The segregation patterns observed in 154 families, which included 31 different mating types and 353 children, confirmed a Mendelian inheritance of four autosomal genes. The distribution of the PGM1 phenotypes observed or expected in a Hardy-Weinberg equilibrium was compared with that of other populations. A significant (P < 0.001) difference was found between the Québec population and a Black population from Keneba, Gambia, West-Africa.

Alleles↗
PubMed1978

[Specific ENT involvement in a case of angio-immunoblastic adenopathy (author's transl)].

The authors report the case of a 78 year old man with an unusual localization (soft palate and tonsil) of an angio-immunoblastic lymphadenopathy. Clinically, the syndrome combines fever, a marked change in general condition, multiple lymphadenopathy and skin rash. From a laboratory standpoint, the picture is dominated by polyclonal hypergammaglobulinemia, often associated with a hemolytic anemia. Histologically, only lymphnode biopsy allows the diagnosis to be made, with the following findings: disruption of the normal architecture of the node, marked vascular neogenesis, presence of acidophilic interstitial substance, lympho-plasmo-immunoblastic proliferation. The course is in general rapidly fatal despite corticosteroids and multiple chemotherapy.

Aged↗
PubMed1973

Serum uric acid: not a discriminator of coronary heart disease in men and women.

Fasting serum uric acid (SUA) was measured using a spectrophotometric method in 635 randomized male subjects aged 20 to 70, as part of an epidemiological study carried our among the civil employees of French origin working for the City of Montreal. It was observed that SUA was not age-dependent and that the overall mean value was 6.26 mg./100 ml. On the other hand SUA was studied in 742 males and 260 females, all of whom had had coronarography. A significant difference in SUA between males and females of 1.26 mg./100 ml. was noted. Correlating the SUA levels with the incidence of CHD or the severity of the lesions in the coronary arteries indicated no relationship between CHD and SUA concentrations in men or in women. The results of this study permit the conclusion that SUA is not a discriminator for CHD.

Adult↗