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Biomedical subjects

C A White

Publications and source records attributed to C A White.

At least 109 records · Page 6Linked to original sources
PubMed1979

Development of gel filtration and specific analyses of urinary carbohydrate and protein material.

Hitherto investigations into urinary carbohydrate and proteinaceous macromolecular material has largely been restricted to non-dialysable fractions. We found that this limits the investigation to less than 1% of the total material present and we present a method for direct analysis of urine without prior concentration or extraction. This method extends existing techniques allowing deeper investigation into necessary and important chemical aspects of health and disease. The method is based on gel filtration using Bio-Gel P2. Means included to overcome the observed adsorption by the gel matrix of relevant material depend on use of high ionic concentration buffers for column elution. The problems of bacterial contamination of the gel matrix are discussed and the use of presterilised urine samples is proposed to prevent contamination. The coupling of the gel filtration column to three specific automated analyses allows simultaneous determination of uronic acid, neutral sugar and proteinaceous material.

Autoanalysis↗
PubMed1978

Intrauterine fetal transfusion, 1965-1976, with an assessment of the surviving children.

The need for IUT in the management of Rh hemolytic disease is likely to continue in the foreseeable future. Recent reports have been skeptical about the success of this procedure and the quality of the surviving infants. Of 84 fetuses who received 134 IUT's, over all, 35.7 per cent survived; 48.3 per cent of the nonhydropic group survived. Fifteen of the 23 survivors between 3 and 11 years of age received intellectual, academic, behavioral, health, and developmental evaluations. When compared to sibling and high-risk control groups, the study children showed no significant differences in intelligence quotients, arithmetic achievements, or reading achievements; their school performance is acceptable and none is presenting significant behavioral problems. Except for an excessive number of umbilical and inguinal hernias, there were no physical abnormalities that could be directly related to IUT.

Amniocentesis↗