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Biomedical subjects

C A Thomas

Publications and source records attributed to C A Thomas.

At least 145 records · Page 8Linked to original sources
PubMed1966

The arrangement of information in DNA molecules.

The anatomy of DNA molecules isolated from mature bacteriophage is reviewed. These molecules are linear, duplex DNA consisting mainly of uninterrupted polynucleotide chains. Certain phage (T5 and PB) contain four specifically located interruptions. While the nucleotide sequence of most of these molecules is unique (T5, T3, T7, lambda), some are circular permutations of each other (T2, T4, P22). Partial degradation of these DNA molecules by exonuclease III predisposes some of them to form circles upon annealing, but indicating they are terminally redundant.

Bacteriophages↗
PubMedDate not supplied

The validity of reading comprehension therapy materials.

This study examines the degree to which reading comprehension therapy materials measure reading comprehension. Thirty-six non-brain-damaged adults (18 females, 18 males) ranging in age from 55 to 75 years participated. They answered written multiple-choice questions from aphasia therapy workbooks before and after reading the paragraphs (n = 40) to which the questions related. Results showed that for each of four sets of workbook materials, subjects answered an average of 24% to 49% more of the questions after reading the paragraphs relative to the number they answered before reading the paragraphs. For questions that could not be answered using one's prior knowledge, subjects were more dependent on having to read the paragraph in order to answer the questions correctly. Based on binomial probabilities, at least half of the questions from 32/40 paragraphs were answered correctly at greater than chance levels without reading the related paragraph.

Aged↗
PubMedDate not supplied

Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease.

The senile plaque is the pathological hallmark of Alzheimer's disease. Senile plaques are composed of beta amyloid fibrils, associated with activated microglia, astrocytes, and dystrophic neurons. We have recently identified class A scavenger receptors as the main receptors mediating the interaction of microglia with beta amyloid fibrils. Adhesion of microglia to beta amyloid fibrils leads to immobilization of these cells on the fibrils, and induces them to produce reactive oxygen species. We propose that interactions of microglial scavenger receptors with fibrillar beta amyloid may stimulate the microglia to secrete apolipoprotein E and complement proteins, which may further contribute to neurotoxicity and neuronal degeneration. Therefore, microglial scavenger receptors may be novel targets for therapeutic interventions in Alzheimer's disease.

Alzheimer Disease↗