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Biomedical subjects

C A Sousa

Publications and source records attributed to C A Sousa.

29 records · Page 2Linked to original sources
PubMed1996

A threshold model analysis of deafness in Dalmatians.

To elucidate the inheritance of deafness in Dalmatian dogs, 825 dogs in 111 litters were evaluated for abnormalities in hearing through the brainstem auditory evoked response (BAER). Recorded along with their quality of hearing (normal, unilaterally deaf, or bilaterally deaf) were the sex, coat color, eye color and the presence or absence of a color patch. The analysis considered deafness an ordered categorical trait in a threshold model. The underlying, unobservable continuous variate of the threshold model was assumed to be a linear function of sex of dog, coat color (black or liver and white), color patch (presence or absence), eye color, the deafness phenotype of the parents and a random family effect. Twenty-six percent of dogs were deaf in at least one ear. Eye color, color patch, sex and the hearing status of the parents were all significant contributions to deafness. The heritability of deafness, on the continuous unobservable scale, was 0.21. This value was computed after correction for eye color, color patch, parental hearing status and sex, implying that significant genetic variation exists beyond the contribution of several single loci.

Animals↗
PubMed1995

Exudative, crusting, and scaling dermatoses.

This article discusses the differential diagnoses for the dermatologic diseases of the cat that present with the primary owner complaint of scaling, crusting, and exudation. Clinical signs, diagnostic tests, and therapies are included for each disease.

Animals↗
PubMed1995

[Systemic lupus erythematosus in the elderly].

The authors report two clinical cases of systemic lupus erythematosus, both in patients over 65 years of age. The discussion includes a brief overview of recent publications on this condition in geriatric patients. Some aspects of systemic lupus in elderly persons are suggested and commented on.

Aged↗
PubMed1994

[Angiosarcoma of the spleen].

Primitive splenic tumors are extremely rare. We report a case, the first at S. José-Hospitais Civis de Lisboa, of a 70 year old woman who presented splenomegaly. She had pelvic irradiation in her past history. MRI revealed a splenic mass characterized as vascular on angiography. She is doing well 12 months after splenectomy. We have found 61 reported cases of this rare tumor whose etiopathogeny is unknown. Early splenectomy should be the first therapeutical approach, since spontaneous rupture is very common and was the feature presented in 34% of patients in the series by Autry et al. As far as cytostatic chemotherapy is concerned, the rarity of this tumor precludes any conclusion about its efficacy, but in metastasized forms it seems that chemotherapy for soft tissue sarcomas may be effective.

Aged↗
PubMed1990

Advances in methodology for diagnosis of allergic skin disease.

Advantages of IDST for diagnosis of atopy and selection of antigens for hyposensitization include the following: 1. The test is widely accepted by clients. 2. The clinician can select individual test allergens based on the patient history and geographic location. 3. It has been the standard for diagnosing atopy in the dog for more than 40 years. Disadvantages of IDST include the following: 1. The test should be performed on a regular basis to maintain reliability. 2. Interpretation of test results is subjective. 3. The test is not standardized on the basis of the examiner, source of the allergen, or reproducibility. 4. There is occasional difficulty in performing the test (e.g., need for sedation). 5. Anaphylaxis is a potential risk. 6. A significant amount of office time is needed to perform the test. 7. Condition of the patient's skin (e.g., lichenification, hyperpigmentation, pyoderma) may preclude its use. 8. There is a possibility of failure to test for appropriate allergens. 9. There may be false-positive and false-negative reactions. 10. Other medications can interfere with the test (e.g., antihistamines, corticosteroids). Advantages of in vitro testing for diagnosis of atopy and selecting antigens for hyposensitization include the following.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1988

Dermatosis associated with feeding generic dog food: 13 cases (1981-1982).

The records of 13 dogs with a crusting dermatosis of the mucocutaneous junctions, pressure points, and trunk were evaluated. All of the dogs had been fed corn- and wheat-based commercial dry dog foods that failed to meet the National Research Council's recommendations for balanced nutrition. The dermatosis in all 13 dogs resolved completely after the diet was changed to one that met the National Research Council's recommendations. The disease was similar to that which has previously been called canine dry pyoderma, but is now known to be a zinc-responsive dermatosis.

Animal Feed↗
PubMed1988

Atopic dermatitis.

The article considers the pathogenesis, clinical signs, diagnosis, and treatment of atopic dermatitis.

Animals↗
PubMedDate not supplied

Propionibacterium acnes immunotherapy in chronic recurrent canine pyoderma. An adjunct to antibiotic therapy.

In a randomized, double-blind, placebo-controlled study, dogs with chronic recurrent pyoderma were treated with antibiotics plus intravenous injections of either Propionibacterium acnes or placebo. Responses (an increase, decrease, or clearing of lesions) were measured and evaluated statistically. Eighty percent (12 of 15) of the dogs treated with antibiotics and P acnes compared with 38% (five of 13) of the dogs treated with antibiotics and placebo responded with significant improvement or complete remission of lesions at the end of the 12-week treatment schedule (P less than 0.05).

Animals↗