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Biomedical subjects

C A Molgaard

Publications and source records attributed to C A Molgaard.

52 records · Page 3Linked to original sources
PubMed1986

Incidence and effectiveness of cerebrospinal fluid shunts in Olmsted County, Minnesota, 1956-1981.

In the period 1956 through 1981, 129 cerebrospinal fluid (CSF) shunt operations were performed on 50 patients who were residents of Olmsted County, Minn. The overall average annual age- and sex-adjusted incidence of initial CSF shunts during this 26-year period was 2.3 per 100,000 person-years. Within 5-year calendar time intervals, the average annual incidence rates per 100,000 person-years ranged from 0.8 (1956-1960) to 4.6 (1971-1975). There were 4 shunt-related deaths, 1 due to a CSF shunt infection and 3 due to acute increases in intracranial pressure. In this analysis of shunt procedures in a defined population, the diagnostic indications and changes over time in CSF shunting devices are also described.

Adolescent↗
PubMed1986

Neuroepidemiology of acquired immune deficiency syndrome.

Neuroepidemiology is that branch of chronic disease epidemiology dealing with disorders that affect the nervous system. The potential for neurological involvement in the diagnosis and pathogenesis of Acquired Immune Deficiency Syndrome (AIDS) has recently been noted. The following review outlines the spectrum of neurological conditions seen in AIDS patients to date. These conditions include: infectious central nervous system complications of viral, bacterial, fungal or protozoan origin; noninfectious central nervous system complications such as neoplasms or cerebral vascular accidents, and cranial and peripheral neuropathy. The incidence of neurological abnormalities among AIDS cases may be seriously underestimated due to a delay in the presentation of an overt neurological syndrome and/or the overlooking of subtle neurological signs and symptoms in such an overwhelming systemic disease.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Current concepts in endometriosis.

There are no conclusive data available on the incidence or prevalence of endometriosis, yet the notion persists that the frequency of cases has dramatically risen in western societies during the past 25 years. Race, familial predisposition, reproductive history, socioeconomic status, personality type and a historical drop in age at menarche have been posited as risk factors for the complex and as-yet-unclear epidemiology of this disorder. The epidemiology of endometriosis is constrained by the difficulty of the diagnosis. Several analytic concepts from epidemiology, however, could be profitably used to further our knowledge of endometriosis. Included are the case-control study, survival and life-table analyses and correlations of psychologic traits with susceptibility to development of the disease. Though none of these techniques is original or without potential for bias, they may be underutilized in solving the conundrum of endometriosis.

Adult↗
PubMed1984

Swine flu vaccine and multiple sclerosis.

Using age-specific rates for multiple sclerosis (MS) based on a national survey, the number of "naturally occurring" new cases of MS among the 45 million swine flu vaccine recipients in the United States is estimated as 1,624 during the year after vaccination, or 31 cases per week. Information from available reports and publications indicates no excess over the expected frequencies. Analyses of admissions for MS before, during, and after the immunization program showed no increase to the US Army hospitals or to the Mayo Clinic. Three independent controlled clinical investigations performed on patients with MS showed no increase in the frequency of exacerbations among those receiving swine flu vaccine as compared with those receiving placebo. Epidemiologic features of MS do not implicate killed virus vaccine as an etiologic factor in onset or exacerbations of the disease. There is no indication from these analyses of any association or cause-and-effect relationship between swine flu vaccine and MS.

Adult↗
PubMed1984

Lack of association of swine flu vaccine and rheumatoid arthritis.

On the basis of available incidence rates, about 22,000 new cases of definite rheumatoid arthritis would have developed fortuitously among the 45 million recipients of the swine flu vaccine during the year after the immunization program. No excess has been detected. Proportional morbidity studies among all Mayo Clinic patients and among the active-duty personnel of the US Army showed no increase in the number of cases of rheumatoid arthritis after administration of the swine flu vaccine. These results do not support the claims based on anecdotal reports of an association of the vaccine with rheumatoid arthritis.

Adolescent↗
PubMed1984

ALS and heavy metals: a pilot case-control study.

We conducted a case-control study of suspected risk factors for ALS among referral patients seen at the Mayo Clinic. Responses to questions about demographic factors, diet, medical history, travel, infectious disease, and other variables were similar in ALS patients and controls. In all but a few items, the responses of the cases and controls did not differ significantly. A significant level of shared exposure to an exogenous agent or environmental insult among cases was noted mainly for heavy metals.

Adult↗
PubMed1982

Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women.

To test the widely accepted--but not well-supported--impression that endometriosis and infertility are associated, we compared the prevalence of endometriosis visualized at laparoscopy in 100 patients being evaluated for infertility and in 200 fertile control subjects (two age-matched to each patient) undergoing tubal ligation. The extent of endometriosis and adhesions noted in the operative reports was classified according to the system proposed by The American Fertility Society. Endometriosis was found in 21 of the 100 infertile patients--mild in 11, moderate in 8, severe in 2. It was found in 4 (2%) of the 200 controls and was mild in all 4. Thus, endometriosis is more often present, and more often severe, among infertile patients. The risk of infertility was estimated to be almost 20 times greater with endometriosis than without. These data support the clinical impression that an association exists.

Adult↗
PubMedDate not supplied

Cholinesterase and self-reported pesticide exposure among pregnant women.

Ascertainment of exposure to cholinesterase-inhibiting pesticides in pregnant subjects is complicated by altered enzyme activity that results from metabolic changes associated with pregnancy. Nevertheless, this study found a high correlation (Pearson chi-square = 13.67, p = .008) between classification of pesticide exposure using self-reported interview information and plasma cholinesterase activity for 203 pregnant women for whom three trimester cholinesterase values were available. All plasma cholinesterase activity values were referenced, by trimester, to a larger sample of 1,050 plasma cholinesterase values from 535 pregnant women. Subjects who lived nearest to agricultural land and who reported that they worked with pesticides in agricultural and other occupations tended to have lower plasma cholinesterase activity than those who reported use of household pesticides only.

Adolescent↗
PubMedDate not supplied

Prevalence of isolated systolic hypertension in Alameda County, California.

Clinical research has suggested that isolated systolic hypertension differs from essential hypertension in terms of pathophysiological change. Yet little is known of the descriptive epidemiology of isolated systolic hypertension. This paper examines the prevalence of isolated systolic hypertension in biracial Alameda County, California. Baseline survey data from the Alameda County Hypertension Project (1978) were used to calculate age and sex percentage of prevalence by race. This condition was rare below age 40, but the percentage of prevalence increased with age. Defining isolated systolic hypertension as diastolic blood pressure less than 90 and systolic blood pressure greater than 160, age-adjusted prevalence was 1.15, 1.31, 1.01, and 2.47 for white men, black men, white women, and black women, respectively. Comparison with the prevalence estimates of isolated systolic hypertension from biracial, rural Evans County, Georgia, indicated that the Alameda County prevalence was significantly lower for white women (p less than .01), black women (p less than .03), and total population (p less than .01). We posit that the larger number of people under care for essential hypertension is responsible for the lower occurrence of pure, isolated systolic hypertension in Alameda County. The results suggest the importance of female family members in the acceptance and promulgation of health promotion efforts for both essential and isolated systolic hypertension at the population level.

Adult↗
PubMedDate not supplied

[The effectiveness of a program of smoking prevention among Mexican schoolchildren].

The main objective of this study was to determine if a program emphasizing training for coping with the social pressures to smoke cigarettes is effective in preventing initial experimentation in the same population. Six elementary schools in Tijuana, Mexico, were included in this prospective study with the participation of 168 sixth-graders. After a baseline survey students were randomly assigned to an intervention and a control group. A program that emphasizes peer-pressure resistance skills to avoid smoking was applied to the intervention group. The control group received no intervention. After 10 months a second survey was carried out in both groups. A significantly smaller proportion of subjects in the intervention group experimented with tobacco during the follow-up period when compared with controls (8.1% vs 20%; p < 0.05). Although designed as a prevention tool, the program also had a therapeutic effect. The proportion of subjects in the intervention group that quit smoking was significantly higher than that of the control group (72% vs 34.78%; p < 0.01). We conclude that this peer pressure resistance skill program was effective in preventing experimentation with tobacco among sixth graders in Tijuana, Mexico.

Adolescent↗