Interaction between effects of beta blockade and cigarette smoke on airways.
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Biomedical subjects
Publications and source records attributed to C A Mitchell.
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The ERA strain of rabies vaccine virus failed to propagate or cause clinical manifestations when instilled into the mammary gland of lactating goats. However, the virus did produce neutralizing antibodies in this gland as a result of repetitive viral stimulation, a "sham infection". The protective property of the concentrated and partly purified milk serum antibody was assessed in mice. In the first trial, protective activity was observed when a single dose of milk serum antibody was administered at intervals up to three days after exposure to virulent rabies virus. In the second trial, using a more concentrated milk serum antibody, about half of the mice were protected when the milk serum was administered up to ten days after exposure to virulent virus.
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Strains of Influenza A representative of human, avian, swine and equine sources were examined for decay when in aerosol form. Strains having their origin in avian and equine hosts were considerably more resistant to decay. Strains derived from human and swine sources were less resistant and bore a similarity in this property.
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Three attempts were made to propagate HERPES SIMPLEX virus in the mammary gland of goats. No active virus resulted. In one instance a marked clinical response was induced in the portion which had been instilled. Repeated instillations induced the synthesis of neutralizing antibody.
The decay rate of six strains of Influenza virus Type A of human origin and eight strains of avian origin were examined in aerosol form under fixed conditions of temperature and humidity. Strains of avian origin were demonstrated to have greater resistance to decay of viability.
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Specific antibodies are found in the globulin fraction of the milk following instillation of mumps virus in the mammary gland of the goat. These antibodies, conjugated with fluerescein isothiocyanate, have been successfully employed in the direct fluorescent antibody staining of mumps virus in infected BS-C-1 cells.
A strain of haemagglutinating virus isolated by Walker and Bannister in 1953 and identified by them as "Filterable Agent" of ducks has been examined. The evidence suggests that although belonging to the Myxovirus Influenza Type A group, it possesses specific strain properties.
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