Biomedical subjects
C A Marino
Publications and source records attributed to C A Marino.
Skin staples in potentially contaminated wounds.
In potentially contaminated surgical procedures, wound infection is more likely when percutaneous sutures are used rather than skin tapes. Our reluctance to use tapes routinely because of variability in their adhesive properties prompted this evaluation of the ability of skin staples to resist abscess formation after contamination of the subcutaneous space. In each of 180 mice, a predetermined quantity of Staphylococcus aureus was injected into the subcutaneous space of a fresh skin incision. Closure with the skin stapler was most resistant to abscess formation. Presumably, percutaneous sutures provide a nidus for bacterial growth in the relatively avascular subcutaneous space. This problem is avoided by the use of skin tapes or staples. For those who are insecure about the strength of a closure with skin tapes, the skin stapler should provide an alternative in potentially contaminated cases where delayed primary closure is not elected.
Testicular uptake of 18F-labeled steroids and comparison with relevant radiopharmaceuticals including 201Tl.
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Synthesis of fluorine-18 labeled 21-fluoroprogesterone.
21-Fluoroprogesterone has been synthesized by the nucleophilic displacement of the mesyl group of the 21-hydroxypregn-4-ene-3,20-dione 21-methanesulfonate by fluoride ion, as formed from the solvolysis of potassium fluoride in acetonitrile, using 18-Crown-6 as the catalyst. In a similar manner, the synthesis of 21-fluoroprogesterone labeled with fluorine-18 has been accomplished, producing approximately 800 muCi of product from 6 mCi of K18F in one hour. This demonstrates that 18F labeled molecules of potential values as readiopharmaceuticals can be prepared rapidly in sufficient yield to allow animal investigation.