Functional pituitary acidophil adenoma in a cat with diabetes mellitus and acromegalic features.
Explore the source record for details and available documents.
Acromegaly↗
Biomedical subjects
C A Lichtensteiger
Publications and source records attributed to C A Lichtensteiger.
Toxic hepatopathy in neonatal foals.
Six foals of three different breeds, born to healthy mares, appeared normal at birth, and died at two to five days of age with icterus, ataxia, head pressing, and terminal hepatic coma. Their livers were less than one-half normal weight. Most of the liver was dark red-brown and slightly rubbery. Histologically, these areas were characterized by severe bile ductule proliferation, mild portal tract fibrosis, and massive hepatocellular necrosis and lobular collapse. A small proportion of the liver, usually on the peripheral part of the lobes, was grossly light brown and slightly raised. Histologically, these areas had mild to severe bile stasis in canaliculi. In the thin marginal zone between the severely affected and mildly affected liver, there was mild bile ductule proliferation and periportal fatty change and necrosis. Alzheimer's type II cells, characteristic of hepatoencephalopathy, were numerous in the brains of all foals. Within two hours after birth, all the foals had been given an oral proprietary nutritional paste, the ingredients of which included a viable Aspergillus sp and an iron compound. Similar lesions were produced in an experimental foal.
Animals↗
Rhamnus cathartica (buckthorn) hepatocellular toxicity in mice.
The toxicity of the plant Rhamnus cathartica was assessed in mice after the plant was identified as a potential cause of an idiopathic neurologic disease in horses. Another member of the Rhamnaceae family, Karwinskia humboldtiana, is neurotoxic to mammals and birds and can induce hepatic degeneration and necrosis. To investigate the toxicity of R. cathartica, a 34-day feeding trial in mice was conducted using a complete rodent diet with 0, 5, or 25% added R. cathartica. No clinical signs or gross lesions were seen, and all major tissues were histologically normal except the liver. The livers of mice fed R. cathartica had marked hepatocellular swelling. Results from periodic acid-Schiff reaction staining and from electron microscopy confirmed that the swelling was due to deposits of monoparticulate glycogen (beta particles) in the cytoplasm. Glycogen deposition is an uncommon toxic change in cells. Apparently, compound(s) in R. cathartica directly or indirectly interfered with glycogen metabolism (either glycogenesis or glycogenolysis). Mechanistic and chronicity studies with R. cathartica are needed to investigate the pathophysiology of the glycogen disturbance and to determine if hepatic injury progresses and if other organs will be injured.
Animal Feed↗