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Biomedical subjects

C A Krueger

Publications and source records attributed to C A Krueger.

25 records · Page 2Linked to original sources
PubMed1978

Resistance of the histamine H2 receptor in guinea-pig heart to blockade by phenoxybenzamine.

Phenoxybenzamine is a potent irreversible H1 receptor antagonist in a variety of tissues. In order to assess the ability of this agent to antagonise the H2-receptor, we have examined the effects of phenoxybenzamine on the histamine-induced positive inotropic effect in electrically driven strips of guinea-pig right ventricle. Even at concentrations as high as 10(-4)M no significant change in the responses to histamine was observed. It is concluded that the histamine H2 receptor is unexpectedly resistant to antagonism by 2-haloalkylamines.

Animals↗
PubMed1975

Thermal alterations in onset and offset rate constants for chlorpheniramine.

The onset and offset rate constants for chlorpheniramine were obtained using the longitudinal muscle of guinea pig ileum. Between 21 degrees C and 37 degrees C these values follwed linear Arrhenius plots with activation energies similar to other biological systems. Below 18 degrees C the nature of the antagonism changed prohibiting estimation of the rate constants. It is concluded that at higher temperatures the histamine receptor behaves in a uniform manner, but below 20 degrees C a change in properties occurs.

Animals↗
PubMed1975

Synthesis and adrenergic neuron blocking properties of some alkylating analogues of bretylium.

A series of ortho-substituted N-alkyl-N-(2-chloroethyl)-benzylamines have been prepared. These compounds are structurally similar to the adrenergic neuron blocking agent bretylium. They were tested for neuron blocking activity using both the innervated rabbit jejunum and the vas-deferens-hypogastric nerve preparation of the guinea pig. Three compounds possessed some adrenergic neuron blocking activity of a prolonged nature, the most potent being N-(2-chloroethyl)-N-(0-bromobenzyl)-ethylamine.

Alkylating Agents↗