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C A James

Publications and source records attributed to C A James.

67 records · Page 4Linked to original sources
PubMedDate not supplied

CHORTLES: a method for representing oligomeric and template-based mixtures.

Screening mixtures of synthetic oligomers or fixed templates (e.g., rings) with varying substituents is increasingly the focus of drug discovery programs. CHORTLES is designed and implemented to facilitate representation, storage, and searching of oligomeric and template-based mixtures of any size. Building upon the CHUCKLES method of representing oligomers as both monomer-based sequences and all-atom structures, CHORTLES compactly represents a mixture without explicitly enumerating individual molecules. This method lends itself to a hierarchy relating mixtures to submixtures and individual compounds, as one finds when deconvoluting mixtures in drug lead discovery programs. In addition, we describe two methods of searching mixtures at the monomer level. We also present a simple pictorial representation for describing all components in a mixture, which becomes essential as the list of monomer names is expanded beyond common names (e.g., amino acids).

Amino Acid Sequence↗
PubMedDate not supplied

Nature vs. nurture: two brothers with schizophrenia.

TOPIC: The nature vs. nurture argument as it pertains to two brothers. PURPOSE: To explore the synergistic effects of heritability and environment in the cases of two brothers with schizophrenia. SOURCES: Review of the literature and the authors' clinical experience. CONCLUSIONS: The nature vs. nurture dichotomy may not be as relevant as looking at the interaction between these two forces.

Environment↗
PubMedDate not supplied

Evaluation of a community health representative program among the Cree of northern Quebec.

The James Bay Cree Community Health Representative (CHR) program was implemented in 1984 to train persons from the Cree population of northern Quebec to act as health care advocates and educators, as intermediaries between the Cree population, health services and local organizations, and as participants in assessing health needs. A formative evaluation was initiated which included quantitative analysis of the daily tasks of CHRs and a qualitative component based on documentary research, observation and semi-structured interviews. The evaluation revealed that CHRs actively participated in the ongoing community health programs mainly through health education; the people interviewed showed a high level of satisfaction. However, direct supervision, sufficient continuing education for the CHRs and better integration into health care teams are long-term goals which need to be emphasized in the program.

Attitude of Health Personnel↗