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Biomedical subjects

C A Clemetson

Publications and source records attributed to C A Clemetson.

18 recordsLinked to original sources
PubMed1999

The key role of histamine in the development of atherosclerosis and coronary heart disease.

Vitamin C-deficiency is known to cause a disturbance of cholesterol metabolism. Suboptimal plasma ascorbic acid levels also cause increased blood histamine levels, which are exaggerated by sleep-lack and other forms of stress. Histaminemia causes separation of vascular endothelial cells. It is here suggested that the histaminemia of stress and ascorbate depletion combine to cause damage to the arterial endothelium and predispose to atherosclerosis, the principal cause of myocardial infarction.

Animals↗
PubMed1981

Abruptio placentae.

Analysis of blood samples from pregnant women has shown that the mean histamine level starts to rise when the plasma ascorbic acid level falls below 1.0 mg/100 ml; it is doubled when the ascorbate level falls to 0.5 mg/100 ml and quadrupled when it falls below 0.2 mg/100 ml. The incidence of abruptio placentae was found to be seven out of 355 (or 2.0%) in women who had plasma ascorbic acid levels above 0.4 mg/100 ml and six out of 31 (19.4%) in women with plasma ascorbate levels below 0.4 mg/100 ml. This difference is highly significant. It is suggested that ascorbic acid deficiency and histamine excess play leading roles in the etiology of abruptio placentae.

Abruptio Placentae↗
PubMed1980

Histamine and ascorbic acid in human blood.

Analysis of 437 human blood samples has shown that when the plasma-reduced ascorbic acid level falls below 1 mg/100 ml, the whole blood histamine level increases exponentially as the ascorbic acid level decreases. When the ascorbic acid level falls below 0.7 mg/100 ml, there is a highly significant increase in the blood histamine level. Oral administration of ascorbic acid (1 g daily for 3 days) to 11 selected volunteers resulted in a reduction of the blood histamine level in every instance.

Ascorbic Acid↗
PubMed1979

Some thoughts on the epidemiology of cardiovascular disease, (with special reference to women "on the pill"). Role of ascorbic acid.

Consideration of nine major factors predisposing to cerebral thrombosis, coronary thrombosis or thrombosis in the deep veins of the calf, reveals that these factors all have one thing in common. Estrogen administration, pregnancy, ageing, smoking, infection, trauma, surgery, soft water and winter season are all associated with a tendency towards decreased plasma ascorbic acid levels. Normally, ascorbic acid deficiency is thought of as causing a tendency towards hemorrhage rather than thrombosis, but it is here suggested that petechial hemorrhages under the endothelium of the blood vessels may precipitate thrombosis on the damaged endothelium. Is not blood coagulation the normal mechanism for the arrest of hemorrhage?

Age Factors↗
PubMed1978

Estrogens in food: the almond mystery.

Studies were made of 36 different nuts, grains, fruits and vegetables commonly used as human foods; each of these was fed to a group of ovariectomized rats for 10 days as a sole diet. The estrogenic activities of the foods were estimated by comparing the uterine weights, uterine fluid volumes and the vaginal cornification indices of each group of rats with those of groups fed other foods. Almonds, cashew nuts, peanuts, oats, corn, wheat and apples all showed estrogenic activity. The original sample of almonds showed the greatest estrogenic activity (p less than 0.01) which was confirmed by repetition of the experiment (p less than 0.01), but subsequent studies of other samples of almonds showed no estrogenic activity. Possible reasons for the disparity of the results with different lots of almonds are discussed.

Animals↗
PubMed1977

Secretion and reabsorption of uterine luminal fluid in rats.

Treatment of ovariectomized rats with oestradiol-17beta and progesterone demonstrated that oestradiol-17beta causes secretion of sodium, potassium and water into the lumen of the uterine horn and that progesterone causes reabsorption of these substances.

Absorption↗
PubMedDate not supplied

Ascorbic acid and diabetes mellitus.

Dehydroascorbic acid, the oxidized form of vitamin C, causes diabetes when injected into animals and has been reported to be present in increased amounts in the blood of patients with diabetes mellitus and even in prediabetics. One of the earliest changes in diabetes mellitus is electron-microscopic evidence of damage to the inner endothelial lining of the blood vessels. Certain bioflavonoids, which are natural non-toxic food substances from plants, like rutin from buckwheat, prevent the oxidation of ascorbic acid and seem to protect the endothelium when given with vitamin C; it is therefore suggested that all vitamin C tablets should be combined with these flavonoids.

Animals↗