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Biomedical subjects

Bryan C McIntosh

Publications and source records attributed to Bryan C McIntosh.

5 recordsLinked to original sources

Managing extracavitary prosthetic vascular graft infections: a pathway to success.

Prosthetic vascular graft infections portend grave consequences if not treated expediently. Despite the low incidence of infection, the potential for limb loss or death greatly magnifies this complication. The surgical management of prosthetic graft infections has evolved over the last 2 decades. With the myriad therapeutic options now available, an algorithm is necessary to provide the optimal surgical treatment of Samson groups 1 through 5 extracavitary infected vascular prostheses. An extensive review of the literature was undertaken to evaluate the most effective management schemes. The authors found that 3 factors--Samson classification, bacteriology, and patient vascular anatomy--are vital to the surgical strategy. These 3 criteria were examined, and an algorithm was developed based on successful clinical and experimental results. This review provides a step-by-step rationale for the surgical management of extracavitary prosthetic graft infections according to the most successful reported outcomes.

Algorithms↗

Head and neck angiosarcomas.

Angiosarcoma of the head and neck is a rare and lethal neoplasm. Data from the Connecticut Tumor Registry was analyzed for all head and neck angiosarcomas between 1980 and 2001. The authors also present the first reported case of familial angiosarcoma of the head and neck region. The 1-year mortality was 48% for all patients with angiosarcomas (38% for males, 69% for females). The 5-year survival was 28% for all patients (38% for males, 15% for females). The combination of surgery and radiotherapy resulted in improved survival compared with either treatment alone.

Adult↗

Endovascular repair of transplant nephrectomy external iliac artery pseudoaneurysm.

The formation of a pseudoaneurysm at the site of transplant nephrectomy is a rare complication, having been reported only six previous times in the literature. Possible causes of this occurrence include infection or rejection of the anastomotic remnant. Diagnosis of the pseudoaneurysm with radiological imaging is necessary. The first successful repair of a noninfected pseudoaneurysm of a transplant nephrectomy patient is described using an endovascular graft.

Aneurysm, False↗

Necrobiosis lipoidica resulting in squamous cell carcinoma.

Necrobiosis lipoidica is a chronic degenerative disease of dermal connective tissue, of unknown etiology, which occurs mostly in diabetic patients. It may occasionally be complicated by squamous cell carcinoma. Since this combination is rare, a high index of suspicion is necessary to establish the diagnosis. We present a case and a review of the literature.

Adult↗