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Biomedical subjects

Brian C J Moore

Publications and source records attributed to Brian C J Moore.

At least 19 recordsLinked to original sources
PubMed2006

Speech perception problems of the hearing impaired reflect inability to use temporal fine structure.

People with sensorineural hearing loss have difficulty understanding speech, especially when background sounds are present. A reduction in the ability to resolve the frequency components of complex sounds is one factor contributing to this difficulty. Here, we show that a reduced ability to process the temporal fine structure of sounds plays an important role. Speech sounds were processed by filtering them into 16 adjacent frequency bands. The signal in each band was processed by using the Hilbert transform so as to preserve either the envelope (E, the relatively slow variations in amplitude over time) or the temporal fine structure (TFS, the rapid oscillations with rate close to the center frequency of the band). The band signals were then recombined and the stimuli were presented to subjects for identification. After training, normal-hearing subjects scored perfectly with unprocessed speech, and were approximately 90% correct with E and TFS speech. Both young and elderly subjects with moderate flat hearing loss performed almost as well as normal with unprocessed and E speech but performed very poorly with TFS speech, indicating a greatly reduced ability to use TFS. For the younger hearing-impaired group, TFS scores were highly correlated with the ability to take advantage of temporal dips in a background noise when identifying unprocessed speech. The results suggest that the ability to use TFS may be critical for "listening in the background dips." TFS stimuli may be useful in evaluating impaired hearing and in guiding the design of hearing aids and cochlear implants.

Adult↗
PubMed2006

Dead regions in the cochlea and enhancement of frequency discrimination: Effects of audiogram slope, unilateral versus bilateral loss, and hearing-aid use.

Following a restricted lesion of the cochlea, which produces a "dead region" (DR), animal experiments have revealed an increase in the cortical representation of frequencies just below the edge frequency (f(e)) of the DR. This may result in improved difference limens for frequency (DLFs) just below f(e). In previous studies to assess this, the value of f(e) was not determined precisely. We measured DLFs using human subjects with DRs for whom the values of f(e) had been determined precisely using psychophysical tuning curves. To prevent use of loudness cues, stimuli for the measurement of DLFs had a mean level falling along an equal-loudness contour and levels were roved over a 12-dB range. DLFs were measured for thirteen subjects with a DR in at least one ear. Almost all subjects with bilateral hearing loss exhibited enhanced DLFs near f(e), consistent with cortical reorganisation. This occurred for subjects whose audiograms had both steep and shallow slopes, regardless of hearing aid use, and for two subjects with low-frequency DRs. One subject with a high-frequency DR in one ear and good hearing in the other ear showed an enhanced DLF in her better ear.

Acoustic Stimulation↗
PubMed2006

Frequency discrimination of complex tones by hearing-impaired subjects: Evidence for loss of ability to use temporal fine structure.

For normally hearing subjects, thresholds for discriminating the fundamental frequency (F0) of a complex tone, F0DLs, increase when the number of the lowest harmonic, N, is above eight. A previous study showed that F0DLs were affected by component phase for N above 7, and it was argued that the increase in F0DLs with increasing N reflects a loss of temporal fine structure information. Here, subjects with moderate hearing loss were tested in a similar experiment. F0DLs were measured for tones with three successive harmonics, added in cosine or alternating phase. The center frequency was 2000 Hz. N was varied by changing the mean F0. A background noise was used to mask combination tones. F0 was roved across trials and N was roved by +/-1, to reduce use of excitation pattern cues. F0DLs were smaller for cosine than for alternating phase for four out of six subjects, and this occurred once N exceeded 5. In contrast to the result for normally hearing subjects, F0DLs decreased with increasing N. Performance was much worse than obtained for normally hearing subjects at the same center frequency, suggesting that most of the hearing-impaired subjects had a poor ability to use temporal fine structure information.

Acoustic Stimulation↗
PubMed2006

Temporal masking curves for hearing-impaired listeners.

The decay of forward masking was investigated for three subjects with moderate sensorineural hearing loss. For such subjects, compression on the basilar membrane (BM) is thought to be largely absent, enabling one to determine the decay of masking without the influence of compression. Temporal masking curves (TMCs), plots of the masker level at threshold against delay between masker offset and signal onset, were measured for delays of 0, 15, 30, 45, 60, and 75 ms, for signal frequencies, fs, of 500, 1000, 2000, 4000, and 6000 Hz. Masker frequencies were 0.5, 0.8, 1.0, 1.15, and 1.3 times fs. Most of the TMCs were well fitted with single-segment straight lines, which, except for high masker levels, were roughly parallel for each fs, supporting the belief that BM compression was largely absent in these subjects. However, the slopes of the TMCs were greater for fs = 500 and 1000 Hz than for higher frequencies, which may indicate that the decay of forward masking is not the same for all signal frequencies. The results suggest that it may not be valid to infer BM compression at low signal frequencies by using a reference TMC for a high fs.

Acoustic Stimulation↗
PubMed2006

Potential benefits of across-aid communication for bilaterally aided people: listening in a car.

We explored whether transferring signals between two hearing aids could improve speech intelligibility in noise. This was evaluated using a simulated conversation in a car; speech was presented to the right ear and car noise was presented either to the right or both ears. In three cross-aid communication conditions, the noise in the right ear was scaled and subtracted from the noise in the left ear. Speech intelligibility was determined for a group of normally hearing listeners and a group with bilateral hearing loss. The hearing-impaired group had relatively higher intelligibility scores when the car noise was diotic, whereas the normal-hearing group had relatively higher intelligibility scores in the binaural (dichotic) conditions. The cross-aid conditions led to improved intelligibility compared to the reference conditions. The results indicate that the transfer of signals between hearing aids may be of benefit when listening to speech in a car.

Adolescent↗
PubMed2006

Modification of the Threshold Equalising Noise (TEN) test for cochlear dead regions for use with steeply sloping high-frequency hearing loss.

Steeply sloping high-frequency hearing loss is often associated with cochlear dead regions. These can be identified by measuring pure-tone thresholds in quiet and in Threshold-Equalising Noise (TEN). However, many patients cannot be adequately tested because the low frequencies in the TEN lead to uncomfortable loudness. We investigated the effect of high-pass filtering on the TEN-test results and the loudness of the TEN. Twenty-four normally hearing subjects and 35 subjects with steeply sloping high-frequency hearing loss were tested, using the standard TEN (TENs), and TEN high-pass filtered at 0.5 kHz (TEN0.5) or 1 kHz (TEN1). For both groups, masked thresholds did not differ across noise types for frequencies above 1 kHz. Over 50% of the hearing-impaired ears tested met the criteria for a dead region at 4 kHz, using all three noise types. However, masked thresholds and the prevalence of positive TEN-test results at 1 kHz were both lower with the TEN 1. The TEN1 was judged the most comfortable noise by 68% of the hearing-impaired subjects. We conclude that high-pass filtering would allow testing at higher TEN levels for patients with steeply sloping hearing loss.

Acoustic Stimulation↗
PubMed2006

Detecting dead regions using psychophysical tuning curves: a comparison of simultaneous and forward masking.

A dead region (DR) is a region of the cochlea where there are no functioning inner hair cells and/or neurones. We compared the edge frequencies, fe, of DRs estimated using four methods: the TEN(HL) test; psychophysical tuning curves (PTCs) measured in simultaneous masking (320-Hz wide noise masker) using a 'fast' method (sweeping masker) and a 'classical' method; and PTCs measured in forward masking (sinusoidal masker) using a 'classical' method. Fourteen subjects with high-frequency DRs were tested. For measurement of PTCs, the signal frequency was chosen to fall inside the DR; the tip frequencies of the PTCs were taken as indicating the values of fe. The values of fe obtained from the PTCs in forward and simultaneous masking (both fast and classical methods) were similar and were usually close to, but somewhat above, the values of fe estimated from the TEN(HL) test. Fast PTCs measured in simultaneous masking are recommended for use in clinical practice, as they give a precise estimate of fe and are quick to administer.

Acoustic Impedance Tests↗
PubMed2006

Frequency discrimination of complex tones; assessing the role of component resolvability and temporal fine structure.

Thresholds for discriminating the fundamental frequency (FO) of a complex tone, FODLs, are small when low harmonics are present, but increase when the number of the lowest harmonic, N, is above eight. To assess whether the relatively small FODLs for N in the range 8-10 are based on (partly) resolved harmonics or on temporal fine structure information, FODLs were measured as a function of N for tones with three successive harmonics which were added either in cosine or alternating phase. The center frequency was 2000 Hz, and N was varied by changing the mean FO. A background noise was used to mask combination tones. The value of FO was roved across trials to force subjects to make within-trial comparisons. N was roved by +/- 1 for every stimulus, to prevent subjects from using excitation pattern cues. FODLs were not influenced by component phase for N= 6 or 7, but were smaller for cosine than for alternating phase once N exceeded 7, suggesting that temporal fine structure plays a role in this range. When the center frequency was increased to 5000 Hz, performance was much worse for low N, suggesting that phase locking is important for obtaining low FODLs with resolved harmonics.

Acoustic Stimulation↗
PubMed2006

Perception of amplitude modulation by hearing-impaired listeners: the audibility of component modulation and detection of phase change in three-component modulators.

Two experiments were conducted to assess whether hearing-impaired listeners have a reduced ability to process suprathreshold complex patterns of modulation applied to a 4-kHz sinusoidal carrier. Experiment 1 examined the ability to "hear out" the modulation frequency of the central component of a three-component modulator, using the method described by Sek and Moore [J. Acoust. Soc. Am. 113, 2801-2811 (2003)]. Scores were around 70-80% correct when the components in the three-component modulator were widely spaced and when the frequencies of the target and comparison different sufficiently, but decreased when the components in the modulator were closely spaced. Experiment 2 examined the ability to hear a change in the relative phase of the components in a three-component modulator with harmonically spaced components. The frequency of the central component, f, was either 50 or 100 Hz. Scores were about 70% correct when the component spacing was < or = 0.5fc, but decreased markedly for greater spacings. Performance was only slightly impaired by randomizing the overall modulation depth from one stimulus to the next. For both experiments, performance was only slightly worse than for normally hearing listeners, indicating that cochlear hearing loss does not markedly affect the ability to process suprathreshold complex patterns of modulation.

Acoustic Stimulation↗
PubMed2006

Effect of modulation maskers on the detection of second-order amplitude modulation with and without notched noise.

The mechanisms underlying the detection of second-order amplitude modulation (AM) were explored. The detectability of second-order AM (fixed depth for each subject) was measured for first- and second-order modulation rates of 16 and 2 Hz, respectively (slow-rate pair), and 50 and 10 Hz, respectively (fast-rate pair), with no masker, a low-band modulation masker (centered at 2 or 10 Hz), and a high-band modulation masker (centered at 16 or 50 Hz). This was done in the absence and presence of an audio-frequency notched noise centered at the carrier frequency of 4000 Hz. Both modulation maskers were "low-noise" noises, to prevent overmodulation. In the absence of notched noise, both modulation maskers impaired performance for the slow-rate pair, but only the low-band masker impaired performance for the fast-rate pair. When notched noise was present, the low-band masker had no significant effect for either rate pair and the high-band masker had an effect only for the slow-rate pair. These results suggest that second-order AM detection is mediated both by an envelope distortion component at the second-order rate and by slow fluctuations in the output of a modulation filter tuned to the first-order rate. When notched noise is present, the distortion component plays little role.

Adult↗
PubMed2006

Effect of noise on the detectability and fundamental frequency discrimination of complex tones.

Percent correct performance for discrimination of the fundamental frequency (0) of a complex tone was measured as a function of the level of a background pink noise (using fixed values of the difference in F0, deltaF0) and compared with percent correct performance for detection of the complex tone in noise, again as a function of noise level. The tone included some low, resolvable components, but not the fundamental component. The results were used to test the hypothesis that the worsening in F0 discrimination with increasing noise level was caused by the reduced detectability of the tone rather than by reduced precision of the internal representation of F0. For small values of deltaF0, the hypothesis was rejected because measured performance fell below that predicted by the hypothesis. However, this was true only for high noise levels, within 2-4.5 dB of the level required for masked threshold. The results indicate that the mechanism for extracting the F0 of a complex tone with resolved harmonics is remarkably robust. They also indicate that adding a background noise to a complex tone containing resolved harmonics is not a good means for equating its pitch salience with that of a complex tone containing only unresolved harmonics.

Acoustic Stimulation↗
PubMed2006

Prediction of absolute thresholds and equal-loudness contours using a modified loudness model.

The loudness model described by Moore et al. [J. Audio Eng. Soc. 45, 224-240 (1997)] forms the basis for a recent ANSI standard for the calculation of the loudness of steady sounds. However, the model does not give accurate predictions of the absolute thresholds published in a recent ISO standard. Here it is described how the assumed middle-ear transfer function in the model can be modified to give more accurate absolute threshold predictions. The modified model also gives reasonably accurate predictions of the equal-loudness contours published in a recent ISO standard.

Auditory Threshold↗
PubMed2006

Effects of level and frequency on the audibility of partials in inharmonic complex tones.

The effect of level and frequency on the audibility of partials was measured for complex tones with partials uniformly spaced on an equivalent rectangular bandwidth (ERB(N)) number scale. On each trial, subjects heard a sinusoidal "probe" followed by a complex tone. The probe was mistuned downwards or upwards (at random) by 4.5% from the frequency of one randomly selected partial in the complex. The subject indicated whether the probe was higher or lower in frequency than the nearest partial in the complex. The frequencies were roved from trial to trial, keeping frequency ratios fixed. In experiment 1, the level per partial, L, was 40 or 70 dB SPL and the mean frequency of the central partial, f(c), was 1201 Hz. Scores for the highest and lowest partials in the complexes were generally high for all spacings. Scores for the inner partials were close to chance at 0.75-ERB(N) spacing, and improved as the spacing was increased up to 2 ERB(N). For intermediate spacings, performance was better for the lower level used. In experiment 2, L was 70 dB SPL and f(c) was 3544 Hz. Performance worsened markedly for partial frequencies above 3544 Hz, consistent with a role of phase locking.

Acoustic Stimulation↗
PubMed2006

Comparison of the roex and gammachirp filters as representations of the auditory filter.

Although the rounded-exponential (roex) filter has been successfully used to represent the magnitude response of the auditory filter, recent studies with the roex(p, w, t) filter reveal two serious problems: the fits to notched-noise masking data are somewhat unstable unless the filter is reduced to a physically unrealizable form, and there is no time-domain version of the roex(p, w, t) filter to support modeling of the perception of complex sounds. This paper describes a compressive gammachirp (cGC) filter with the same architecture as the roex(p, w, t) which can be implemented in the time domain. The gain and asymmetry of this parallel cGC filter are shown to be comparable to those of the roex(p, w, t) filter, but the fits to masking data are still somewhat unstable. The roex(p, w, t) and parallel cGC filters were also compared with the cascade cGC filter [Patterson et al., J. Acoust. Soc. Am. 114, 1529-1542 (2003)], which was found to provide an equivalent fit with 25% fewer coefficients. Moreover, the fits were stable. The advantage of the cascade cGC filter appears to derive from its parsimonious representation of the high-frequency side of the filter. It is concluded that cGC filters offer better prospects than roex filters for the representation of the auditory filter.

Acoustics↗
PubMed2005

The relationship between stream segregation and frequency discrimination in normally hearing and hearing-impaired subjects.

We examined the relationship between the fission boundary (FB) at which a sequence of pure tones alternating between two frequencies cannot be heard as two separate streams and the frequency difference limen (FDL), using normally hearing subjects and subjects with cochlear hearing loss. The stimuli used in the two tasks were as similar as possible in duration and inter-tone interval. The frequency range examined was 250-8000 Hz for the normally hearing subjects and 250-2000 Hz for the hearing-impaired subjects. For normally hearing subjects, the FBs were almost invariant with frequency when expressed as ERB(N) values; the mean FB was about 0.4 ERB(N). The FDLs, also expressed as ERB(N) values, increased for frequencies above 2000 Hz. The ratio FB/FDL was roughly constant at 7-9 in the frequency region 250-2000 Hz, but decreased for higher frequencies, reaching about 1 at 8000 Hz. For the hearing-impaired subjects, FB/FDL ratios varied over a large range (1-40), and were not systematically related to the amount of hearing loss. These results suggest that the FB is not determined solely by the discriminability of successive tones.

Acoustic Stimulation↗
PubMed2005

Factors affecting psychophysical tuning curves for hearing-impaired subjects with high-frequency dead regions.

A dead region (DR) is a region of the cochlea where there are no functioning inner hair cells and/or neurons. DRs can be detected using the threshold-equalizing-noise (TEN) test, but psychophysical tuning curves (PTCs) are sometimes used to give a more precise estimate of the edge frequency of a DR; a shifted tip of the PTC indicates a DR. We show here that the shapes of PTCs for hearing-impaired subjects can be influenced by the detection of beats and simple difference tones (SDTs). As a result, PTCs can have tips at f(s), even when f(s) falls in a DR. PTCs were measured for subjects with mild to moderate low-frequency and severe high-frequency hearing loss using sinusoidal and narrowband noise maskers (80-, 160-, 320-Hz wide): (1) in quiet; (2) in the presence of additional lowpass filtered noise (LF noise) designed to mask SDTs; (3) in the presence of a pair of low-frequency tones designed to interfere with the detection of beats (MDI tones). In condition (1), the PTCs were often W-shaped, with a sharp tip at f(s). This occurred less for the wider noise bandwidths. For subjects with good low-frequency hearing, the LF noise often reduced or eliminated the tip at f(s), suggesting that this tip was partly caused by detection of SDTs. For the sinusoidal and 80-Hz wide noise maskers, the addition of the MDI tones reduced the masker level required for threshold for masker frequencies adjacent to f(s), for nearly all subjects, suggesting a strong influence of beat detection. To minimize the influence of beats, we recommend using noise maskers with a bandwidth of 160 or (preferably) 320 Hz. In cases of near-normal hearing at low frequencies, we recommend using an additional LF noise to mask SDTs.

Acoustic Stimulation↗
PubMed2005

Dead regions and noisiness of pure tones.

Some hearing-impaired subjects report pure tones as sounding highly distorted and noise-like. We assessed whether such reports indicate that the tone frequency falls inside a dead region (DR). Nine hearing-impaired and four normally hearing subjects rated pure tones on a scale from 1 to 7, where 1 indicates clear tone and 7 indicates noise. A white noise was presented as a reference for a sound that should be rated as 7. Stimuli covered the whole audible range of frequencies and levels. The noisiness ratings were, on average, higher for hearing-impaired subjects than for normally hearing subjects. For the former, the ratings were not markedly different for tones with frequencies just outside or inside a DR. However, ratings always exceeded 3 for tones falling more than 1.5 octaves inside a DR. The results indicate that judgement of a tone as sounding noise-like does not reliably indicate that the tone frequency falls in a DR. Both normally hearing and hearing-impaired subjects rated 0.125 kHz and 12 kHz tones as somewhat noise-like, independently of the existence of a DR.

Adult↗