Biomedical subjects

Brenda Wilson

Publications and source records attributed to Brenda Wilson.

5 recordsLinked to original sources

PubMed2006

Partnering in oncogenetic research--the INHERIT BRCAs experience: opportunities and challenges.

Today it is common to conduct research in collaboration with colleagues from different disciplines and institutions. The INterdisciplinary HEalth Research International Team on BReast CAncer susceptibility (INHERIT BRCAs), involves Canadian and international experts from diverse fields working with health service providers, patients and collaborators from the World Health Organization and other European networks. Evidence-based information and knowledge transfer drive our efforts to advance genomic research to understand the genetic basis of cancer susceptibility and treatment response. Several goals reveal the interdisciplinary team approach: (a) to estimate the prevalence and penetrance of BRCA1 and BRCA2 mutations and their deleterious impact upon different populations; (b) to pinpoint novel breast cancer susceptibility loci; (c) to assess the efficacy of clinical interventions; (d) to address changes in quality of life and health-related behaviour from the decision to undergo genetics testing and during follow-up; (e) to evaluate legal, social and ethical implications; and, finally; (f) to promote professional and public education by facilitating the transfer of research findings to clinical practice and informing policy makers. The lessons learned by the INHERIT research team and future challenges are presented.

Breast Neoplasms↗

PubMed2005

Perceptions of working as a nurse in an acute care setting.

This paper focuses on the changing nature of nurses' perceptions of their work. It examines the major sources of satisfaction and dissatisfaction experienced by nurses working at a major teaching hospital in May 2000. Coding categories reflected four components of nurses' work experiences: organizational, interpersonal, structural and professional. Organizational aspects of work were over-represented as sources of satisfaction and dissatisfaction and related to perceived changes in management philosophy (increasing productivity with limited resources). Study findings provide some clear goals for responsive, sensitive management.

Adult↗

PubMed2005

Prevalence of enzootic simian viruses among urban performance monkeys in Indonesia.

Animal reservoirs are the most important sources of emerging infectious diseases that threaten human populations. Global travel and tourism bring ever-increasing numbers of humans into contact with animals, increasing the likelihood of cross species transmission of infectious agents. Non-human primates come into contact with humans in a variety of contexts and may harbor infectious agents with zoonotic potential. We investigated the prevalence of infection with enzootic simian viruses among 20 urban performance monkeys (Macaca fascicularis) in Jakarta, Indonesia. This report documents for the first time evidence of infection with four simian viruses in urban performance monkeys. Simian foamy virus was detected by PCR in 52.9% of the macaques. Antibodies to simian retrovirus were detected in 10.5% of the macaques. Antibodies to Cercopithecine Herpesvirus 1, were detected in 5.3% of the macaques. Similarly, antibodies to simian T-cell lymphotropic virus were detected in 5.3% of the macaques. No evidence of infection with simian immunodeficiency virus was detected in these macaques. These results suggest that urban performance monkeys are a reservoir for enzootic simian viruses known to be capable of infecting humans.

Animals↗

PubMed2005

Primate-to-human retroviral transmission in Asia.

We describe the first reported transmission to a human of simian foamy virus (SFV) from a free-ranging population of nonhuman primates in Asia. The transmission of an exogenous retrovirus, SFV, from macaques (Macaca fascicularis) to a human at a monkey temple in Bali, Indonesia, was investigated with molecular and serologic techniques. Antibodies to SFV were detected by Western blotting of serum from 1 of 82 humans tested. SFV DNA was detected by nested polymerase chain reaction (PCR) from the blood of the same person. Cloning and sequencing of PCR products confirmed the virus's close phylogenetic relationship to SFV isolated from macaques at the same temple. This study raises concerns that persons who work at or live around monkey temples are at risk for infection with SFV.

Adult↗

PubMed2003

Integrated services pathways (ISP): a best practice model.

Under the National Demonstration Hospitals Program, Phase 3 (NDHP3), Flinders Medical Centre (FMC) developed a best practice model for integrating acute care services with primary and community services. The project methodology included the examination of existing literature, involvement of consumers and other key stakeholders and the application of contemporary change and project management practices. Common elements were identified from four NDHP3 clinical service enhancement projects--aged care, cardiac surgical gastroenterology and orthopaedic services. The generic elements were transferred to the model. FMCs approach focused on developing a generic model that could be applied to clinical programs in a range of acute care settings. Although a number of barriers were encountered, the NDHP3 experience has shown that integration can be improved at the clinical program level without changing financial and management structures.

Australia↗