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Biomedical subjects

Bogdan Rydzewski

Publications and source records attributed to Bogdan Rydzewski.

6 recordsLinked to original sources

[Osteosarcoma of the larynx].

The authors present a case of rare laryngeal neoplasm--osteosarcoma, which generated many diagnostic and treatment difficulties. Its main cause was nonspecific symptoms and laryngoscopic view, positive tuberculous history and positive tuberculosis tests. The first histopathological examination was "angioleiomyoma exulcerans, chronic inflammation and granulation." No cancer nor tuberculosis was found". After the physiologic consultations and with positive tuberculin test the tuberculocidal treatment was applied, but it bought no success. The larynx was split then, intraoperative histopathological examination gave the result: "Cellulae carcinomatosae". The total laryngectomy was performed. Postoperative immunohistochemical examination was "Osteosarcoma of larynx". The patient was not evaluated for radio- or chemotherapy. Admitted to the hospital after 5 months with neck tumor and reactional lymph nodes by the right side of the neck. Crile's operation was performed. During the postoperative course some metastatic lymph nodes on the left side of the neck and in lungs were detected. Patient noted to chemotherapy.

Aged↗

[Smell and taste in drug addicts].

The main objective of this study was to establish the degree of influence of various illicit drugs, taken into the body in different ways, on the senses of smell and taste. Other possible factors, that might have caused disturbances in normal functioning of both senses, were outlined. The studied group consisted of 48 drug addicts, between the age of 16 and 48 years, addicted to various illicit drugs for several years. Olfactory testing included two methods. First quantitative method described by Elsberg and Levy, modified by Pruszewicz, was used to establish the smell detection threshold. Then the University of Pennsylvania Smell Identification Test was used as a method for odor identification. The sense of taste was tested with the use of method described by Krarup and modified by Pruszewicz. The results showed disturbances in olfactory performance (combined in both method) in 52.1% of all drug abusers, and 16.7% of them were diagnosed with ageusia when the sense of taste was tested. The route of administration of illicit drugs proved to be a statistically significant factor that might have caused disturbances of smell perception and identification in the study group. Drug abusers who were taking drugs intravenously and those who smoked and inhaled various drugs had the most significant olfactory problems. Both means for assessing smell function were statistically compared and the results showed that approximately 75% of drug users with olfactory disturbances had olfactory problems in both tests.

Adolescent↗

[Influence of tonsillectomy in adults on the concentration and glycosylation profile of acute phase proteins].

Chronic tonsillitis (ch.t.) in adults can have the effect on immunological system and its function. The aims of this study were: 1. the estimation of concentration and glycosylation of acute-phase serum protein (a.ph.s.p.)--C-reactive protein (CRP), alpha 1-acid glycoprotein (AGP), alpha 1-antichymotrypsin (ACT), transferrin (Tf) and the concentration of immunoglobulins (Ig) and alpha 2-macroglobulin (alpha 2-M) in adults with ch.t. 2. the influence of tonsillectomy on the concentration and glycosylation a.ph.s.p. in I week and 6-8 months after surgery and determination of normalization estimated parameters. 116 patients with ch.t. and 15 healthy persons were evaluated. In all patients with ch.t. the concentration of acute-phase serum protein, alpha 2-M and immunoglobulins were determined before, in I-II day, VII day and 6-8 months after surgery. In patients with ch.t. were observed the significantly higher the concentration of CRP, AGP, ACT, IgG and the significantly decreased the concentration of serum transferrin before tonsillectomy, as an effects of immunological response on chronic inflammation. Tonsillectomy induced further increases the concentration of a.ph.s.p. and the highest value attained the CRP level. The change of glycosylation of AGP and ACT were results of chronic inflammatory process and analysis the glycosylation of these proteins can be useful in the estimation of activity of inflammatory process. The normalization of the concentration of acute-phase serum protein were observed in 6-8 months after tonsillectomy and confirmed the withdrawal of inflammatory process.

Acute-Phase Proteins↗

[A comparison of water and air stimulated bithermal-caloric test and the usefulness of both methods in otologic surgery].

The most commonly used method of testing the responses of the labyrinths is Water Stimulated Bithermal-Caloric Test of Fitzgerald-Hallpike. Before planning an otiatric surgery it is necessary to support by documentary evidence the responses of the vestibular organ in the ear planned to be operated on, however, irrigation with water may cause damage to structures of the ear and may intensify symptoms of the diseases and eventually make the treatment more difficult. In some centers where Water Stimulated Bithermal-Caloric Test were used alone, or a combination of air and water stimulated caloric test were performed, it seemed to be difficult to compare the results of both tests. In this study I tried to establish parameters of stimuli obtained in the Air Stimulated Bithermal-Calorics test that evoked nystagmus, similar to those obtained in the Fitzgerald-Hallpike water stimulated test. It was determined that the duration of nystagmus in both water and air stimulated bithermal-caloric tests were identical when the temperature of "cold" air wave was 26 degrees C, whereas "warm" air wave had the temperature of 48 degrees C and the time of stimulation for both tests was 80 seconds.

Adult↗

[Iatrogenic foreign bodies found in the middle ear as a result of prosthetic management].

In the past few months two patients were admitted and operated on for liquid silicone that hardened to form a sponge-like mass after it was accidentally poured into the tympanic cavity during an impression taking procedure. In on case an atrophic eardrum was torn open and in the other the accident was the result of a misdiagnosed chronic otitis. In both cases a tympanoplasty was performed to remove the sponge from the tympanic cavity and to restore the conductive structures in the middle ear. Both cases demonstrate the importance of following the rules of conduct precisely, in taking the prosthetic impressions and the obvious necessity for a thorough primary examination of patients by experienced otologists with a use of a microscope.

Aged↗

[Cat scratch disease--diagnostic problems].

Etiology, epidemiology and clinical symptoms of Mollaret's disease, also known as Cat-scratch disease, were described. Four cases of treated patients were presented. One patient with a history of type I Diabetes mellitus presented clinical symptoms of Mollaret's disease, however, after investigation he was finally diagnosed with malignant lymphoma and was given chemotherapy. In other cases some symptoms were also doubtful, but the final diagnoses were made upon positive results of serological reactions and all patients recovered completely after a few week antibiotic treatment. All patients had frequent contacts with cats. A significant divergence between the results of histopathological, serological and ultrasonographic findings lead to a conclusion that a certain diagnosis of Cat-scratch disease can only be made with the use of positive results of serological reactions.

Adult↗