Biomedical subjects

Bing Cheng

Publications and source records attributed to Bing Cheng.

8 recordsLinked to original sources

PubMed2026

Hepatocyte-derived LRG1 primes the liver for metastasis and impairs immunotherapy.

The liver undergoes active remodeling by the primary tumor prior to metastatic spread. However, the mechanisms by which hepatocytes dictate the liver-specific tropism of tumors remain elusive. Here, we identify hepatocyte-derived leucine-rich alpha-2-glycoprotein 1 (LRG1) as a key mediator of liver premetastatic niche (PMN) formation. Clinically, elevated serum LRG1 levels are correlated with an increased risk of liver metastasis in patients and multiple mouse models. Mechanistically, LRG1 remodels the hepatic microenvironment by driving immunosuppressive neutrophil accumulation, impairing the function of effector T cells and dendritic cells, and enhancing angiogenesis in the liver, thereby fostering a prometastatic landscape. Hepatocyte-specific ablation of LRG1 dampens premetastatic niche formation and significantly reduces the metastatic burden in vivo. Hepatic LRG1 induced by tumor-associated inflammation via IL-6/STAT3 signaling promotes liver metastasis through the formation of TGFBR/PI3K/AKT axis-driven neutrophil extracellular traps (NETs). Importantly, therapeutic blockade of LRG1 not only suppressed liver metastasis but also reprogrammed the hepatic niche toward an immune-activated state, sensitizing tumors to anti-PD-1 therapy. Collectively, our findings reveal a hepatocyte-LRG1 axis that drives liver premetastatic niche remodeling and highlight LRG1 as a promising target for the prevention and treatment of liver metastasis.

Animals↗

PubMed2004

[Phacoemulsification using burst mode].

OBJECTIVE: To observe the effect of burst mode combined with high vacuum on phacoemulsification. METHODS: Nine hundreds and fifty-four eyes (819 patients) were randomly divided into three groups (continue group, pulse group and burst group). Each group consisted of 318 eyes. A temporal clear corneal incision was performed in each group. Various phaco modes were used. In continue group, the vacuum was 160 mm Hg, max phaco power was 60%. In pulse group, vacuum was 160 mm Hg and the power was 60%. In burst group, vacuum was 250 - 300 mm Hg and the power was 60%. Actual phaco power, phaco time, visual acuity, corneal endothelial cell loss and other complications were recorded. RESULTS: The actual phaco power in these 3 groups was 25.36% +/- 6.65%, 19.54% +/- 3.50% and 6.27% +/- 1.27%, respectively. Phaco time in these 3 groups was (222 +/- 30), (186 +/- 41) and (36 +/- 6) seconds, respectively. In comparison of the power and time among these 3 groups, the difference between continue group and pulse or burst group was significant (P = 0.005 and 0.0001). Visual acuity was significant improved in all 3 groups postoperatively. The difference between the continue group and the pulse group was not significant. The difference between the continue group and burst group was statistically significant. There was no statistically significant difference in mean number of corneal endothelial cell between these 3 groups preoperatively. Endothelial cell loss postoperatively was lower in the pulse and burst groups than that in the continue group. The difference was significant between the continue group and pulse or burst group (P = 0.005 and 0.001). Serious corneal edema occurred more frequently in the continues group than that in the pulse and burst groups. CONCLUSION: High vacuum combined with pulse or burst phaco mode reduced phaco time and actual phaco power consumed during phacoemulsification, especially in the burst mode, which enhanced the effectiveness of phaco chop and reduced the loss of corneal endothelial cell and corneal edema. It is safe to use the burst phacoemulsification clinically.

Aged↗

PubMed2004

[The causes and reposition of fixed intraocular lens pupillary capture in children].

OBJECTIVE: To analyze the cause of fixed intraocular lens (IOLs) pupillary capture in children and investigate the rational methods to reposit intraocular lens. METHODS: Thirty-one eyes (30 cases) with fixed intraocular lens pupillary capture under 14 years old were analyzed based on clinical data; the causes and the complications were also evaluated. The IOL reposition procedure was performed in 8 cases (8 eyes) with severe complications. RESULTS: Different extent of secondary cataract, posterior iris synechia caused by severe postoperative uveal tract reaction were existed in all 30 cases, corecleisis was occurred in some severe cases. During reposition operation, different extent of lens cortex regeneration in the equator portion of capsule bag was found in all eight cases. CONCLUSION: Fixed pupillary capture of IOL is the common complication in children after cataract surgery. Severe postoperative uveal tract reaction and secondary cataract and lens cortex regeneration are the major causes of intraocular lens pupillary capture. The intraocular lens could be reposited through iris synechia separation, regenerated lens cortex cleaning and secondary cataract extraction.

Adolescent↗

PubMed2003

[Changes of lens capsule after phacoemulsification].

OBJECTIVE: To observe the changes in the lens capsule after phacoemulsification and its effects on the position of intraocular lens (IOL) and to demonstrate the best position of IOL in relation to the anterior capsule. METHODS: The present series comprised 141 eyes in 127 patients underwent phacoemulsification and foldable lens implantation with 5 mm continuous curvilinear capsulorhexis. The changes in the lens capsule and the position of IOL with dilated pupil were observed using slit lamp microscope 3 months after the operation. RESULTS: Capsular bag shrinkage and white Soemmering ring along the margin of capsulorhexis were observed in all cases. Three different kinds of relationship between anterior capsule opening and the IOL optic surface were found, including the non-capture (68 eyes), partial-capture (52 eyes) and total-capture (21 eyes) relationships. The incidence of central posterior capsule opacification (PCO) was significantly higher in the total-capture group (47.6%) than that in the non-capture (11.7%) and partial-capture (21.2%) groups (P < 0.01). IOL in well centered position was significantly higher in the non-capture (91.2%) and total-capture (81.0%) groups than that in the partial-capture group (42.3%) (P < 0.01). CONCLUSION: In the present study, various changes in the lens capsule were observed after phacoemulsification and foldable lens implantation. It is suggested that keeping the IOL in a non-capture position is a key point to avoid the occurrence of PCO and IOL decentration.

Aged↗

PubMed2003

[The preliminary study of photolysis for cataract surgery].

OBJECTIVE: To evaluate the safety and efficiency of Dodick-ARC photolysis machine (a kind of Nd:YAG laser system) in the using of cataract surgery. METHODS: 52 eyes of cataract (fifty-two patients) were undergone photolysis with Dodick-ARC laser system and foldable intraocular lenses (IOLs) implantation. The hardness of nuclei was graded as N(1.0) to N(4.0) of LOCS III classification system. Before and after operations, the intraocular conditions, visual acuity, corneal thickness and operative complications were recorded. The time of follow-ups was more than 6 months. RESULTS: The operations were accomplished in 28 eyes and were changed into Phacoemulsification in 24 eyes. Posterior capsule rupture occurred in 2 cases (3.8%). Severe corneal edema was found in 3 cases (5.8%) that disappeared in 1 to 2 weeks. Preoperative visual acuity was < 0.05 in 19 cases, 0.05 - 0.3 in 28 cases and 0.4 - 0.5 in 5 cases. Postoperative visual acuity was < or = 0.3 in 1 case, 0.4 - 0.5 in 12 cases, 0.6 - 0.9 in 25 cases and > or = 1.0 in 14 cases. The mean values of pachymetry was 0.59 mm preoperatively and 0.60 mm in 3 months postoperatively (P = 0.097). CONCLUSION: Photolysis using Dodick-ARC Nd:YAG laser system is a safe and effective method for cataract surgery. The further improvement of equipment and surgery techniques is needed.

Adult↗

PubMed2002

[Macular image changes of optical coherence tomography after phacoemulsification].

OBJECTIVE: To investigate the effects of phacoemulsification on the macula following uncomplicated phacoemulsification by optical coherence tomography (OCT). METHODS: Eighty eyes of the senile cataract were chosen randomly. The uncomplicated phacoemulsification was performed. OCT was examined preoperatively and 1 week after the surgery. Preoperative visual acuity, the retinal thickness and phaco power were compared with those after surgery. RESULTS: In 80 eyes, the preoperative mean foveal thickness was (142.9 +/- 16.7) micrometer and the postoperative (157.9 +/- 36.7) micrometer, the difference being not significant (P > 0.05). Three eyes had macular edema 1 week after surgery. In 11 eyes with Tyndall sign (+ +), the mean postoperative foveal thickness was thicker than the mean preoperative value (P < 0.05). In lower phaco power group, the mean postoperative foveal thickness was (156.2 +/- 18.3) micrometer and the higher phaco power group was (172.6 +/- 32.9) microm (P < 0.05). The best corrected visual acuity after surgery had a negative correlation with the retinal thickness. CONCLUSIONS: The retinal thickening and macular edema can be found after uncomplicated phacoemulsification. The higher phaco power results in significant inflammation and thicker retina. The visual consequences were proportional to the degrees of macular thickening.

Aged↗

PubMed2002

[Tear film changes after phacoemulsification].

OBJECTIVE: To evaluate tear film changes after phacoemulsification. METHODS: This prospective randomized study involved 68 consecutive patients with age-related cataract (79 eyes) who underwent phacoemulsification. Tear break-up time, Schirmer I test (S I t) value, corneal fluorescein staining, tear film pattern by DR-1 tear interfermetry and the height of tear meniscus were measured preoperatively and 1 day and 2, 7, 14, 30, 180 days postoperatively. RESULTS: At 1 day and 2 days postoperatively, the mean tear break-up time reduced greatly, and the number of patients who showed III to V tear film pattern, the mean S I t value, the height of tear meniscus and fluorescein staining scores increased significantly (P < 0.001 for day 1, P < 0.005 for day 2). S I t value at 7 days postoperatively (P = 0.831) and the height of tear meniscus at 14 days returned to their preoperative values (P = 1.000). The tear break-up time, corneal fluorescein staining scores and the grades of tear film pattern all recovered at 30 days postoperatively (P > 0.05). At 30 days postoperatively, 19.3% of patients showed shorter tear break-up time and less S I t value than that of preoperative day. In addition, 1/9 of the patients with normal preoperative tear film experienced dry eye at 30 days postoperatively. The cases with tear break-up time < 10 seconds compared to patients with tear break-up time >/= 10 seconds were more easily to show tear instability postoperatively (relative risk 13.5, 8.25, 20.0, 39.0, 8.6, 3.9 at 1 day and 2, 7, 14, 30, 180 postoperative days, respectively). CONCLUSION: Phacoemulsification significantly alters the tear break-up time, S I t value, corneal fluorescein staining, tear film pattern and the height of tear meniscus. Some patients with normal tear film may experience dry eye after surgery. Patients with preexisting tear break-up time < 10 seconds are easily at risk of experiencing the tear film instability postoperatively.

Aged↗

PubMed2002

[A clinical observation of low and negative power intraocular lens implantation].

OBJECTIVE: To evaluate the clinical effects of the low power and negative power acrylic foldable intraocular lens (Acrysof IOL) implantation. METHODS: Forty patients (56 eyes) received phacoemulsification and above mentioned Acrysof IOL implantation. Intraoperative and postoperative complications, visual acuity and refractive error were observed. RESULTS: No intraoperative complications occurred. During 3 months of follow-up, the corrected visual acuity was less than 0.1 in 2 eyes, 0.1 - 0.4 in 12 eyes, 0.5 - 0.9 in 36 eyes, and 1.0 - 1.5 in 6 eyes. Posterior capsular opacification was found in 4 eyes (7.2%). Capsular distension was found in 1 eye (1.8%). No retinal detachment was seen. CONCLUSION: It is safe and effective for highly myopic patients with cataract to implant a low or negative power Acrysof IOL after phacoemulsification.

Adult↗