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Bin Zhang

Publications and source records attributed to Bin Zhang.

At least 145 records · Page 8Linked to original sources
PubMed2005

[Magnetic resonance imaging diagnosis of cervical lymph node metastasis from lingual squamous cell carcinoma].

BACKGROUND & OBJECTIVE: The identification of cervical lymph node metastasis is very important for the treatment and prognosis prediction of lingual squamous cell carcinoma. Simple palpation is unsatisfactory for the accurate diagnosis of cervical lymph node metastasis. Magnetic resonance imaging (MRI) has been increasingly used to evaluate cervical lymph node status. This study was to explore MRI features of cervical lymph nodes metastasis from lingual squamous cell carcinoma, and to investigate the role of MRI in diagnosing this kind of metastasis. METHODS: The MR images of 448 nodal levels in 92 patients with lingual squamous cell carcinoma were analyzed, and compared with their pathologic diagnoses. RESULTS: Of the 488 nodal levels, 166 (37.1%) were proved pathologically as metastases, level II was the most commonly involved. False-positive and false-negative rates of MRI diagnoses were higher in levels I, and II than in levels III, IV, and V. There is no statistical difference in the incidence of cervical lymph nodes metastases of different nodal levels between squamous cell carcinoma of corpus linguae and that of radix linguae. Obvious central nodal necrosis was seen in 76 nodal levels at MR images,which were proved pathologically as metastatic nodes. Extracapsular nodal invasions in 34 nodal levels had irregular contour, and infiltration of adjacent fat tissues around lymph nodes, among which carotid artery walls were encased in 2 cases. With the diagnostic criteria of metastasis as the minimal nodal diameter of >/= 8 mm or central nodal necrosis, the diagnostic sensitivity, specificity, and accuracy of MRI were 79.5%, 90.4%, and 86.4%, respectively. CONCLUSIONS: The incidence of cervical lymph nodes metastasis from lingual squamous cell carcinoma is highest in level II. MRI diagnostic criteria of cervical lymph nodes metastasis are nodal size, central nodal necrosis, and irregular contour of lymph nodes. MRI may diagnose lymph node metastasis in levels III-V with high accuracy, While its diagnosis accuracy on levels I-II is affected by the sites, which weakens its clinical value.

Adult↗
PubMed2005

[Epidemic survey on TCM syndrome typing and preliminary discussion on TCM etiology and pathogenesis of fatty liver].

OBJECTIVE: To investigate the common TCM syndrome types of fatty liver by way of epidemic questionnaire, their occurrence ratio, and the correlation between various syndrome types and objective indexes. METHODS: A total of national wide 503 subjects with fatty liver were enrolled, the TCM syndromes, body mass index (BMI), abdominal perimeter/hip circumference, liver function, blood lipids, B ultrasonic examination and CT in them were observed and recorded. RESULTS: In the 46 symptoms investigated in total, the first ten symptoms in order of appearing rate were lassitude, obese, oral dryness, vertigo, hypochondriac distending pain, soreness and pain in loin, spiritlessness, oral bitterness, aching and weakness in knee and abdominal distention. The mostly appeared tongue figures were pale and corpulent or pale dim tongue proper, white greasy or yellow greasy tongue coating, and the mostly appeared pulse figures were taut, taut-thin and taut slippery. Statistical cluster analysis showed that syndromes of fatty liver could be typed into 4 TCM types, the asthenia Pi-Shen with Gan-stagnation type, the asthenia Pi-Shen type, the asthenia Pi with phlegm-heat type and the unclassified type. Among them the asthenia Pi-Shen with Gan-stagnation type was the commonest one, which accounted to 62.32%. CONCLUSION: The mostly appeared syndrome type of fatty liver was asthenia Pi-Shen with Gan-stagnation type. The TCM pathogenesis of fatty liver was deficiency of origin, mainly deficiency of Shen, involving Pi, with excess superficiality, the turbid-phlegm and blood stasis.

Adolescent↗
PubMed2005

[Factors associated with acute ST-segment elevation myocardial infarction with normal angiographic findings of the coronary artery].

OBJECTIVE: To identify the factors related to acute ST-segment elevation myocardial infarction (STEMI) with normal angiographic findings of the coronary artery. METHODS: An retrospective analysis of the electrocardiographic, echocardiographic, and angiographic data of 271 STEMI cases was conducted. Of these patients, 29 had normal coronary artery by angiography and from the rest patients presenting abnormal angiographic findings of the coronary artery, 60 were randomly selected to serve as the control group. Multiple logistic regression analysis was performed to identify the independent factors related to acute STEMI with normal coronary artery by angiography. RESULTS: The incidence rate of STEMI with normal coronary artery was 10.7%. Univariate analysis showed that age, smoking, diabetes mellitus, absence of pre-infarction angina, and wall motion score were related to STEMI with normal coronary artery (P<0.05), whereas multiple logistic regression analysis identified the former 3 factors as the related factors (P<0.05). Wall motion score, left ventricular ejection fraction, cardiac index, and stroke volume index were higher, and cardiac events fewer in patients with normal coronary artery than in those with abnormal coronary artery (P<0.01). CONCLUSION: Acute STEMI with normal coronary artery is more likely to occur in young smokers without pre-infarction angina, possibly in association with spontaneous reperfusion.

Adult↗
PubMed2005

[Analysis of the causes of postoperative chest or/and abdomen colic in benign prostatic hyperplasia].

OBJECTIVE: To analyze the causes of chest or/and abdomen colic with in 1 week after prostatectomy and transurethral resection of the prostate (TURP). METHODS: Retrospective studies were made on 120 cases of benign prostatic hyperplasia (BPH) with postoperative colic in the chest or/and abdomen from October 2001 to October 2002, 35 (Group A) treated by prostatectomy and the other 85 (Group B) by TURP. RESULTS: In sequence of frequency, the causes of the postoperative chest or/and abdomen colic were bladder spasm, catheter block, acute gastroenteritis, angina and acute myocardial infarction. CONCLUSION: The causes of chest or/and abdomen colic after prostatectomy are multiple. If the causes are timely established and corresponding measures immediately taken, its complications can be minimized.

Aged↗
PubMed2005

[Time effect window of sildenafil for the treatment of erectile dysfunction].

The therapeutic efficacy of sildenafil for the treatment of erectile dysfunction is correlative with the pharmacokinetics of the drug and the time of sexual behavior. More and more researches on the time effect window of sildenafil for the treatment of erectile dysfunction have elucidated the least time to achieve sufficient penile hardness for intercourse and to reach the best erectile state after the drug administration, as well as the therapeutic effect of the long-term treatment with the drug.

Erectile Dysfunction↗
PubMed2005

[An island pectoralis major myocutaneous flap for the reconstruction of tongue and floor of mouth].

OBJECTIVE: To evaluate an island pectoralis major myocutaneous flap for immediate reconstruction of the total tongue body and the floor of the mouth after radical resection of bilateral tongue carcinoma involved. METHODS: Form October 2000 to December 2002, seven patients with bilateral tongue carcinoma were selected to treat with salvage surgery, and an island pectoralis major myocutaneous flap were applied for immediate reconstruction of total body of tongue and floor of mouth. RESULTS: Six flaps survived well. Only one flap showed a partial necrosis, with no submandibular fistula, infection, and other complications. The reconstructed tongue and floor of mouth worked well. The speaking and swallowing functions were satisfactory after 2 approximately 16 months' follow-ups. Only one patient died of lung metastasis carcinoma in 9 months after the operation. CONCLUSIONS: The island pectoralis major myocutaneous flap could be an ideal selection for the immediate reconstruction of the total tongue body and the floor of mouth.

Adult↗
PubMed2005

[Analysis of different reperfusion methods for acute ST segment elevation myocardial infarction].

OBJECTIVE: To evaluate significance of different reperfusion methods in the treatment of acute ST segment elevation myocardial infarction (STEMI). METHODS: A retrospective analysis of the clinical data of electrocardiography (ECG), echocardiogram, and angiography was conducted in 271 cases of STEMI treated in our hospital. Of these patients 31 were treated by primary percutaneous coronary intervention (PCI), and 44 by intravenous thrombolysis with urokinase, including 26 with thrombolytic treatment with concomitant PCI and 18 with rescue PCI. RESULTS: The patients receiving primary PCI, thrombolytic therapy along with PCI, and rescue PCI did not exhibit significant differences in age, sex, diabetes, hypertension, hyperlipidemia, smoking status, symptom onset to treatment time, or collateral circulation (P>0.05). The incidence of cardiac events including unstable angina, complex ventricular arrhythmia, and cardiac insufficiency were not significantly different between the 3 groups (P>0.05), nor was Killip class, number of Q waves on ECG, wall motion score, left ventricular ejection fraction, cardiac index, or stroke volume index (P>0.05). CONCLUSION: Combination of thrombolytic therapy and interventional therapy can be a safe and effective treatment of STEMI, and rescue PCI may benefit the improvement of the left ventricular function.

Angioplasty, Balloon, Coronary↗
PubMed2005

[Responses of antioxidation system of Cynodon dactylon to recirculated landfill leachate irrigation].

With pot experiment, this paper studied the membrane lipid peroxidation and the variations of antioxidation system in Cynodon dactylon under recirculated landfill leachate irrigation. The results showed that when irrigated with low dilution ratio (< 25%) leachate, the chlorophyll a/b ratio increased with increasing dilution ratio, membrane permeability and MDA and H2O2 contents were in adverse, and membrane lipid peroxidation was relatively weak. However, with the increasing leachate dilution ratio (> 25%), there existed an obvious negative fect on Cynodon dactylon, i.e., the chlorophyll a/b ratio decreased, while cell membrane permeability and MDA and H2O2 contents increased, which meant that the membrane lipid peroxidation was accelerated. The contents antioxidants AsA, GSH and Car also showed the similar trend, i.e., they increased with increasing leachate dilution ratio when irrigated with low dilution ratio leachate, but decreased under medium or high dilution ratio leachate irrigation. Among three test anti-oxidative enzymes, SOD and POD activities showed a similar change test antioxidants, and POD activity was more sensitive, while CAT activity was on the contrary. The contents test antioxidants and the activities of SOD and POD were negatively and significantly correlated to MDA content, indicating that they might play an important role in preventing Cynodon dactylon from cell membrane lipid peroxdation.

Antioxidants↗
PubMed2005

[Different psychological impact of immediate breast reconstruction and delayed breast reconstruction].

OBJECTIVE: To investigate the optimal time to perform breast reconstruction after mastectomy for breast cancer. METHODS: From May, 2001 to March, 2004, 52 patients were performed immediate or delayed breast reconstruction after mastectomy. They were given questionnaires to assess for satisfaction, sexuality, anxiety, depression, body image and self-esteem. RESULTS: 97% of the IR group patients were very or moderately satisfied while only 75% of the DR group were so (P = 0.026). Only 6% of the IR group compared with 30% of the DR group felt an obvious impairment of their sexual attractiveness (P = 0.043). Anxiety (P = 0.014) and depression (P = 0.006) were less in the IR group than the DR group. Body image (P = 0.012) and self-esteem (P = 0.003) were superior in the IR group. CONCLUSIONS: If tumor characters and patient health permit, immediate breast reconstruction should be performed after mastectomy for breast cancer.

Adult↗
PubMed2005

[Analysis of misdiagnosis in 33 cases of aortic dissection].

OBJECTIVE: To compare the clinical characteristics, clinical course and laboratory findings of diagnosed and misdiagnosed cases of aortic dissection (AD). METHODS: The data of 33 cases of AD were collected for a retrospective review. All the patients underwent examination with X-ray and B-type ultrasound, and diagnosis of the suspected cases was further verified CT and magnetic resonance imaging according to the criteria of presence of false lumen or free valves. Diagnosis of AD was established in 18 of the 33 patients, including 14 male and 4 female patients aged from 20 to 79 years with a mean of 55.8+/-11.4 years. Misdiagnosis occurred in 15 patients including 12 male and 3 female patients aged 22-75 years with a mean of 56.2+/-10.8 years. RESULTS: No significant differences were found between the diagnosed and misdiagnosed groups in terms of age, sex, hypertension, coronary heart disease, chest pain, heart murmur, pericardial effusion, pleural effusion, average systolic and diastolic pressure, white blood cell count, creatine phosphokinase (CK) and its isoenzyme CK-MB, or De Bakey type III (P>0.05). Significant differences in peripheral large blood vessel murmur, asymmetric blood pressure of the arm and leg, ST segment variation, arrhythmia, and De Bakey types I and II were noted between the two groups (P<0.05). In cases misdiagnosed as acute coronary syndrome, ST segment variation, creatine kinase, arrhythmia, and white blood cell count were significantly different from those in cases of diagnosed as AD (P<0.01), but CPK-MB and cardiac troponin I were comparable. CONCLUSION: The initial symptoms, disease course, cardioelectrographic changes and creatine kinase of AD can be easily confused with those of acute coronary syndrome, and special attention should be given to their differentiation.

Adult↗
PubMed2005

[Selective neck dissection in the management of tongue squamous cell carcinoma with clinically negative nodes].

OBJECTIVE: To compare the effectiveness of selective neck dissection (SND) with radical or modified radical neck dissection (RND) for the management of tongue squamous cell carcinoma with clinically negative nodes (cN0). METHODS: There were 33 patients who were treated with SND (including 14 supraomohyoid neck dissection and 19 level I -IV neck dissection ) between January 1998 and December 2002. According to T classifications, treatment modality and pathological status of lymph node (pN), the control group of 33 patients were randomly selected from the cN0 tongue squamous cell carcinoma patients who were treated with RND between January of 1980 and December of 1997. Kaplan-Meier was used to calculate the rate of regional recurrence and 5-year survival rate. RESULTS: The neck recurrent for RND population was 9.1% (3 patients), which was not statistically different from the neck recurrent in the SND population 12.1% (4 patients). Also, the 5-year survival rates were no statistic difference between SND and RND groups (82.9%, 28 patients vs 78.8%, 26 patients). The rate of recurrent outside the dissection area for level I -IV neck dissection population was 0, which was statistically different from the rate of recurrent outside the dissection area in the supraomohyoid neck dissection population (14.3%, 2 patients). CONCLUSIONS: Comparing to the radical or modified neck dissection, the SND offered the same oncologic compromise for patients with cN0 tongue squamous cell carcinoma. I -IV neck dissection was recommended.

Carcinoma, Squamous Cell↗
PubMed2005

[Relationship between basal core promoter combined point mutation of hepatitis B virus and TCM syndrome type].

OBJECTIVE: To investigate the relationship between basal core promoter (BCP) combined point mutation of hepatitis B virus (HBV) and TCM syndrome type. METHODS: One hundred and two patients with chronic hepatitis with positive HBV DNA and hadn't ever been treated by Lamivudine and interferon were differentiated according TCM syndrome differentiation into 5 types, two excess types (damp-heat blocking zhong-jiao type and blood stasis blocking collaterals type) and three deficiency types, gan-stagnation with pi-dificiency type, gan-shen yin-deficiency type and pi-shen yang-deficiency type. The serum HBV DNA, hepatic biochemical indexes, and the mutation of BCPnt 1762A-T and nt1764G-A combined point were determined, respectively. RESULTS: The variant strain positive rate detected in the excess type was significantly higher than that in the deficiency type, the highest rate appeared in patients of damp-heat blocking zhong-jiao type. CONCLUSION: BCP combined point mutation may be liable to happen in patients of TCM excess type, especially in patients of damp-heat blocking zhong-jiao type.

Diagnosis, Differential↗
PubMed2005

[Model for predicting survival of patients with severe virus hepatitis and its clinical application].

OBJECTIVE: To study prospectively the short-time survival of patients with severe virus hepatitis using model of severe liver diseases (MSLD) established by our previous study. METHODS: One hundred and three patients with severe hepatitis were included by cohort study. Of them, there were 85 patients with severe chronic hepatitis patients, 10 acute and 8 subacute severe hepatitis patients, respectively. The follow-up endpoint was 6 months. The cutoff score of the MSLD was determined by receiver operating characteristic cure (ROC) statistic analysis, and the survival of severe hepatitis patients in 2 weeks, 4 weeks, 3 months and 6 months were estimated by Kaplan-Meier statistic analysis. RESULTS: The cutoff MSLD score for predicting survival was 5. The survival curves of group A (total MSLD score< or =4) was significantly better than group B (total MSLD score> or =5, P<0.000). After treatment for 2 weeks, the survival rate in 2 weeks and 4 weeks was 37.9% and 3.5%, respectively, if MSLD score had no change or increased. The survival rate in 2 weeks, 4 weeks and 3 months was respectively 61.5%, 15.4%, 5.8% if the MSLD score decreased 1. Then, the survival in 2 weeks, 4 weeks, 3 months and 6 months was respectively 95.0%, 90.0%, 63.9% and 52.4% if MSLD score decreased 2 or more. CONCLUSION: It is suggested that MSLD may be valuable in predicting 6-month survival of severe virus hepatitis patients. It may be used to determine the efficacy of medical treatment and to guide clinical decision.

Adolescent↗
PubMed2005

[Preventive and therapeutic effects of recombinant IFN-alpha2b nasal spray on SARS-CoV infection in Macaca mulata].

OBJECTIVE: To study the preventive and therapeutic effects of recombinant IFN-alpha2b for nasal spray on SARS-CoV infection in Macaca mulata (rhesus monkey). METHODS: Ten rhesus monkeys were divided into two groups, 5 in interferon group, and 5 in control group. Before and after SARS-CoV attack, the virus was detected in samples such as pharyngeal swab in all the two groups by Real-time PCR (RT-PCR) and virus isolation was performed. RESULTS: After virus attack, the level of SARS-CoV-specific IgG and neutralizing antibody were induced by SARS-CoV in the interferon group was weaker than in control group. Hematology items showed no apparent changes after virus attack in treated group. Through pathological examination, the morphology of the lung tissues of two Macaques in the treated group was normal, while the other three displayed the interstitial pneumonia with the thickened septum and infiltration with mononuclear cells. Among which, one monkey showed part of thickened septum fused with each other. These lesions in the interferon treated animals were similar to those seen in the animals in control group, but with smaller scope of pathological changes. No significant abnormity was detected in other organs. CONCLUSION: Recombinant IFN-alpha2b could effectively interdict or weaken SARS-CoV injury in monkeys.

Animals↗
PubMed2005

[A field trial of recombinant human interferon alpha-2b for nasal spray to prevent SARS and other respiratory viral infections].

OBJECTIVE: To study the preventive effect of recombinant human interferon alpha-2b for nasal spray against SARS and other common respiratory viral infections by serum-epidemiological method. METHODS: A randomized, placebo-controlled, double-blind field trial study in populations with 14,391 persons from SARS prevalent cities or provinces in China during May-Jun, 2003 and Dec-Apr, 2004. Interferon alpha-2b was given twice per day, once 9 x 10(5) IU by nasal spray for 5 days. Serum samples were taken at 15 days after last administration. Serological tests included SARS IgG antibody and IgM antibodies against influenza B, parainfluenza virus types 1-3, adenovirus type 3, 7 and respiratory syncytial virus by using commercial ELISA kits. RESULTS: No statistically significant difference in serum SARS IgG antibody positive rate was found between the interferon and control groups among 2,757 serum samples. On the other hand, after using interferon, all four respiratory viruses (parainfluenza virus types 1-3 influenza B, adenovirus types 3, 7 and respiratory syncytial virus) in interferon group had lower IgM antibody positive rates than those in control group. Among them there were statistically significant differences between the interferon and control groups for parainfluenza virus, influenza B and adenovirus. The preventive efficacy of interferon against four respiratory viruses was different, from high to low, the rank was Flu B (66.76%), parainfluenza types 1-3 (66.75%), RSV (39.61%) and adenovirus (32.86%). The average preventive efficacy was 50.27%. CONCLUSION: The recombinant human interferon alpha-2b for nasal spray could decrease the rates of common respiratory viruses infection in the selected population.

Administration, Intranasal↗
PubMed2005

[Preliminary study on nasal spray of interferon alpha-2b used for prevention of rubella and measles virus infections].

OBJECTIVE: To evaluate the efficacy of the interferon alpha-2b nasal spray in prevention of rubella and measles virus infections. METHODS: The properly selected volunteer groups have been divided into interferon alpha-2b experimental and control group. The experimental group received interferon alpha-2b treatment by nasal spray for 2 days before the immunization, then both groups were challenged with rubella and measles attenuated live vaccine respectively through nasal spray. The sera from pre-immunization and 21 and 28 days after immunization were collected to test the IgG antibody titers. The influence on the viral antibody titer reflects the viral preventive effect by interferon alpha-2b. RESULTS: The antibody titer difference of measles virus between experimental and control group was 1.26 (21 day) and 2.96 (28 day), there were statistically difference between them; the difference of rubella virus was 0.95 (21 day) and 0.37 (28 day), but there were no statistically differences found. CONCLUSION: The preliminary results showed that the interferon alpha-2b can be used as prevention method for measles and rubella viral infections.

Administration, Intranasal↗
PubMed2005

[A controlled randomized trial of the use of combined L-carnitine and acetyl-L-carnitine treatment in men with oligoasthenozoospermia].

OBJECTIVE: To determine the efficacy and safety of combined L-carnitine and acetyl-L-carnitine therapy in infertile males with oligoasthenozoospermia. METHODS: One hundred fifty patients with oligoasthenozoospermia were randomized selected into treatment and control groups. The treatment group with 90 patients were given L-carnitine (2 g/d) and acetyl-L-carnitine (1 g/d) orally, twice a day. The patients in control group were given Vitamin E 100 mg plus Vitamin C 100 mg, tid. The oral therapy lasted three months and patients accepted sperm analysis every one month. The L-carnitine level in seminal plasma was examined by high performance liquid chromatography (HPC). Side effects as well as pregnant rate were observed. RESULTS: In the treatment group, 85 patients out of 90 finished the three month treatment. Female spouses of 10 patients (11.6%) achieved pregnancy. Moreover, their forward motile sperm per ejaculation, total motile sperm, as well as the concentration of L-carnitine in seminal plasma were increased significantly (P < 0.01). In control group, 53 patients out of 60 completed three months therapy. Two pregnancy (3.7%) was observed. Though some increase was seen in number of forward motile sperm and total motile sperm per ejaculation, the changes were not statistically significant (P > 0.05). The difference of the pregnant rate between two groups was statistically significant. No side effects were found. CONCLUSION: Combined treatment with L-carnitine and acetyl-L-calmitine can be an effective and safe option for treating oligoasthenozoospermia by means of significantly improving forward motile sperm and total motile sperm per ejaculation, as well as increasing pregnant rates.

Acetylcarnitine↗