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Biomedical subjects

Bernardo Liberato

Publications and source records attributed to Bernardo Liberato.

7 recordsLinked to original sources
PubMed2005

Evolving concepts regarding transient ischemic attacks.

Transient ischemic attack (TIA) represents one end of the spectrum of focal brain ischemia, the other being completed infarction or ischemic stroke. The evolving technologic advancements in neuroimaging continue to change and sharpen the definition, epidemiology, and management of TIA. As a powerful risk factor for ischemic stroke, TIA deserves widespread public and physician education, urgent attention and investigation, and rapid management. The recognition and treatment of TIA provides an excellent opportunity for stroke prevention that is often missed or poorly recognized among physicians.

Animals↗
PubMed2004

Nonconvulsive status epilepticus in patients with cancer: imaging abnormalities.

BACKGROUND: Convulsive status epilepticus may cause reversible neuroimaging abnormalities. These cortical changes have been reported rarely in association with nonconvulsive status epilepticus. OBJECTIVE: To describe patients with cancer who had reversible magnetic resonance (MR) imaging abnormalities from nonconvulsive status epilepticus and whose altered mental status and MR imaging findings were initially considered to result from a structural lesion related to their underlying tumor. DESIGN: Retrospective study. SETTING: Department of Neurology at Memorial Sloan-Kettering Cancer Center, New York, NY. PATIENTS: Eight patients with a diagnosis of nonconvulsive status epilepticus who underwent MR imaging. RESULTS: Enhancing cortical abnormalities were observed on MR images in 4 (50%) of 8 patients with cancer who had impaired mental status and an electroencephalogram demonstrating seizure activity. Follow-up MR images showed neuroimaging improvement or resolution in all patients. CONCLUSIONS: Cortical enhancement on MR images in patients with cancer who have altered mental status may be due to nonconvulsive status epilepticus and not recurrent or metastatic tumor. If electroencephalography is not immediately available at initial evaluation, a trial of anticonvulsant therapy deserves consideration.

Adult↗
PubMed2003

Temporal evolution of diffusion after spontaneous supratentorial intracranial hemorrhage.

BACKGROUND AND PURPOSE: The evolution of apparent diffusion coefficient abnormalities during supratentorial intracranial hemorrhage in normal appearing brain tissue has not been described. Recent investigations using diffusion imaging have revealed increased apparent diffusion coefficient in perihematomal tissue. We report brain tissue abnormalities beyond the visibly abnormal region ipsilateral and contralateral to the hematoma. This preliminary effort should generate meaningful clinical prognostic indicators for moderate size hemorrhages in large scale studies. METHODS: Using the neurology patient encounter database at a tertiary care hospital, we retrospectively identified patients who presented with acute focal neurologic deficits, had CT scans of the head that confirmed spontaneous intracranial hemorrhage, and had a MR images obtained within the first 6 hr to 30 days postictus. The regions identified as targets of this investigation were the hemorrhage and surrounding T2 signal intensity abnormality and the visibly normal supratentorial cerebral tissue. RESULTS: Ninety-five patients were admitted during a period of 25 months. Fifteen patients met the criteria for the study. Elevated whole brain diffusion was shown as early as 6 hr after intracranial hemorrhage. This increase in diffusion was comparable in both hemispheres. Diffusion values in the lesion (hematoma plus T2 signal intensity abnormality) increased slowly with peak increases noted 2 to 3 days after the ictus. CONCLUSION: Diffuse early cerebral response occurs in normal appearing brain tissue both ipsilateral and contralateral to the visibly abnormal hematoma, manifested by increased apparent diffusion coefficient. This response is present before the local response is fully developed. Supratentorial intracranial hemorrhage results in an early diffuse brain response with increased apparent diffusion coefficient in normal appearing brain.

Adult↗