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Biomedical subjects

Bernard Hoerni

Publications and source records attributed to Bernard Hoerni.

18 recordsLinked to original sources
PubMed2005

Fludarabine phosphate-CVP in patients over 60 years of age with advanced, low-grade and follicular lymphoma: a dose-finding study.

The aim of this study was to establish a safe and effective regimen of fludarabine phosphate, cyclophosphamide, vincristine and prednisone (F-CVP) as first-line treatment for elderly patients with advanced, low-grade non-Hodgkin's lymphoma. Twenty-three patients >60 years were assigned successively to eight treatment cycles (Dose level 1: low F, low CV [n=4]; 2A: high F, low CV [n=8]; 2B: low F, high CV [n=4]; 3: high F, high CV [n=7]). High and low levels were: F, 25 and 20mg/m(2), respectively (Days 1-5); C, 750 and 500 mg/m(2), respectively (Day 1); and V, 1.4 and 1mg/m(2), respectively (Day 1). Patients received P at 40 mg/m(2) on Days 1-5. Response was assessed after Cycles 2, 4, 6 and 8. At level 3, dose-limiting toxicity (opportunistic infections and neutropenia) became evident, particularly after Cycle 6. Further patients were recruited at Dose level 2A. All regimens proved effective, with an OR rate of 78% (65% CR), and 3-year survival of 65% (+/-10%). Among 18 responders, 51% were still in response at 3 and 5 years. The study shows that this combination therapy is highly effective. The addition of F to CVP at Dose level 2A was feasible and increased the CR rate, with good tolerability in elderly patients.

Administration, Oral↗
PubMed2004

[Telephone in medical practice].

The telephone is increasingly used as a means of communications between patients and physicians. It has several advantages (mainly for the patient), but also several drawbacks (mainly perceived by the physician). Specific training in telephone interview techniques, including possible pitfalls, should be offered to all medical students.

Communication↗
PubMed2003

[Management of cancer patients by general practitioners. Results of a survey among 422 physicians in Aquitaine].

OBJECTIVE: To have a better knowledge on the role of the general practitioner in the management of cancer patients, their opinion on communications with the specialists and their training in oncology. METHOD: In March 2000, a questionnaire was sent to a random sample of 730 general practitioners in the Aquitaine area. RESULTS: We obtained 440 answers (60%). The general practitioners declared taking care of a mean of 16 cancer patients among their clientele and seeing 5 new cases every year. Two thirds of them decided on the orientation of their patients, case by case. Nearly 70% of the practitioners reported difficulties, notably psychological, in the case of relapses or during the terminal phase. The majority (94%) considered the quality of the information provided by the specialists as correct or good. Globally, the practitioners would prefer to be more involved in the treatment of their cancer patients and 82% would accept to ensure the follow-up of the patients in remission. CONCLUSION: The expectations of the general practitioners defined in this study merit reflection for the development of treatment networks in order to improve their organisation and the collaboration between general practitioners and specialists.

Adult↗
PubMed2003

[Medicine, ethics and money].

Since the end of the Middle Ages, physicians have been paid in different ways for the care they give. This payment must respect the ethical principles of equity, autonomy and benevolence-beneficence. Equity requires that everybody be treated according to his needs and not according to his means, the necessary means being offered by physicians or provided by society. Autonomy requires that the physician be independent so that no other consideration--including his own material interest--takes precedent over the patient's interests. Benevolence-beneficence places the emphasis on means, in accordance with evidence-based medicine, results being impossible to guarantee.

Altruism↗
PubMed2002

Quality of life in patients with aggressive non-Hodgkin's lymphoma. Validation of the medical outcomes study short form 20 and the Rotterdam symptom checklist in older patients.

In the elderly population, cancer treatment aims to cure and/or maintain Quality of Life (QoL). However, there is little QoL data to provide evidence for QoL benefits for some of the cancer treatments. This pilot study developed valid QoL questionnaires in French, for patients over 65 years with a diagnosis of large cell lymphoma, part of the Lymâge phase II study. They were asked to complete two questionnaires, the Medical Outcomes Study Short Form 20 (MOS SF20; generic) and the Rotterdam symptom checklist (RSCL; cancer-specific). Between June 1995 and April 1997, questionnaires were returned by 63 of 89 patients. This article reports the process undertaken to adapt the English version to a French setting, and provides the results of factor analysis, convergent and discriminant validity and reliability. Our data suggest that QoL questionnaires can be used in elderly patients. These two questionnaires are validated in French and would help us to analyse the QoL of elderly patients with the development of new treatments as done in the Lymâge study.

Aged↗
PubMedDate not supplied

[Medical ethics. Evolution century after century].

Since Hippocrates had succeeded to specify the medical science his ethical principles-kindness, deference to human life, privacy of home-were expressed in the so-called Hippocratic Oath. Later some principles of non-discrimination were added, chiefly in the field of the medical research.

Ethics, Medical↗
PubMedDate not supplied

[Life and death of the medical lie].

For several centuries many practitioners and people believed that fine words could help the recovery of patients and a friendly lie could conjure away a fatal prognosis. At the end of the 20th century, reversal of opinion imposed the truth of which advantages were more numerous than drawbacks.

Deception↗