Biomedical subjects

Beata Rostkowska-Nadolska

Publications and source records attributed to Beata Rostkowska-Nadolska.

6 recordsLinked to original sources

PubMed2006

[RANTES expression in nasal polyps fibroblasts; spontaneously and after stimulation with lipopolisaccharides (LPS) and phytohemagglutinin (PHA)].

INTRODUCTION: According to the results of research carried out by a number of authors, one of the main mechanisms of the generation of polyps is local inflammatory processes accompanied by immune system disorders. It has recently been shown that a number of differentiation factors and inflammatory mediators may be involved in the growth of nasal polyps. RANTES is a eosinophil chemoattractant factor likely could play an important role in a chronic inflammatory response in the nasal tissue that subsequently leads to the development of nasal polyps. OBJECTIVE: The objective of this study was detection of the chemokine RANTES in nasal polyps fibroblasts and researching influence of stimulation with lipopolisaccharides and phytohemagglutinin for RANTES expression in cultured nasal fibroblasts in vitro. METHODS: Nasal polyps were obtained from 17 subjects (9 atopic and 8 nonatopic) during polypectomy. RANTES was measured by immunofluorescence method. RESULTS: Intensive granular luminescence was observed in all cytoplasm of cells with the exception of nucleus. Immunoreactive RANTES was found to be present in 70% of cells. We not find increase percentage of positive RANTES fibroblasts after stimulation with lipopolisaccharides and phytohemagglutinin. RANTES expression was similar in the both: atopic and nonatopic polyps. CONCLUSIONS: This study demonstrates that cultured fibroblasts derived from both atopic and nonatopic patients release RANTES spontaneously and after stimulation with lipopolisaccharides and phytohemagglutinin. This observation and the finding that RANTES is present in nasal polyps fibroblasts suggest that this chemokine may be an important mediator of eosinophil in both atopic and nonatopic nasal polyposis. More research needs to expand on chemotactic factors such as RANTES and their interplay with other local cytokines.

Adult↗

PubMed2006

[Haemangiopericytoma of the nasal cavity as a cause of recurrent epistaxis--case report].

A case of haemangiopericytoma of the nasal septum in 73-year-old female admitted to the Department of Otolaryngology of Wroclaw Medical University with a history of recurrent epistaxis and progressive right monolateral nasal respiratory obstruction is reported. On admission presented smooth, cyanotic, easily bleeding lesion in the nasal cavity on the right. Nose CT scans identified presence of a soft-tissue mass arising from the nasal septum. She was treated with a complete surgical resection of the mass. The diagnosis was established based on the careful histopathological examination. Haemangiopericytomas are rare soft-tissue neoplastic lesions, occurring mainly in adults, originating from pericytes and primarily arising in the lower extremities and retroperitoneum. Haemangiopericytomas of head and neck are very unusual and comprise about 15 to 30%; of these, approximately 5% occur in the sinonasal area. Authors have presented etiology, symptomatology, histopathological features, differential diagnoses, diagnostic and therapeutic management. Malignant and benign clinical course have been described.

Aged↗

PubMed2005

Trace elements in nasal polyps.

The reason why nasal polyps occur has not been explained yet. In the literature, the role of immunological factors are considered and broadly discussed, but there is no information on the role of microelements in the pathogenesis of nasal sinusal polyposis. In this study, concentrations of Cu, Se, Zn, and Pb in tissue of nasal polyps were determined. The tissue samples were taken from 41 patients during polypectomia procedures, whereas healthy tissue from nasal mucosa was sampled from 10 patients during endonasal surgery. The concentrations of the elements were determined by atomic absorption spectrometry. It was found that the concentrations of all the elements were signifcantly lower in polyp tissues than in healthy nasal mucosa. The reasons for this are unclear in the present study.

Adolescent↗

PubMed2005

[Cytological examination of nasal polyps smears].

Cytological evaluation of smears taken from the surface of nasal polyps were presented. 30 patients were examined. In 60% of the smears the prevalence of neutrophils were noticed. The metaplasia of stratified squamous cell epithelium, lesion of cell's nuclei and blurring of cytoplasm were observed in this cases. In 23 cytograms predominance of eosinophils were found. In cytograms with predominance of eosinophils, numerous stratified columnar epithelium were present. According to cytological examination the polyps were divided to neutrophil and eosinophil type. Cytograms taken from eosinophil polyps resembling smears from atopic rhinitis. In the case of neutrophil polyps the changes in cytograms characteristic for chronic rhinitis were found.

Adolescent↗

PubMed2003

[Electrophysiologic tests of the auditory apparatus and vestibular organ in Usher syndrome].

Usher syndrome is a congenital autosomal dominant inherited disease characterised by hearing, balance and vision problems. The aim of the work was an evaluation of hearing and vestibular organ in the chosen group of patients with Usher syndrome diagnosed. Material consisted of 10 persons (5 males and 5 females) aged from 16 to 46 years with Usher syndrome diagnosed. All the patients have been in constant ENT and Ophthalmology Clinics' care. Complex hearing and balance organ, including posturography, as well as complex ophthalmologic examination were performed in each case. Medium or severe perceptive cochlear hearing loss, proper function of vestibular organ and slight elevation of stabilograms parameters were found in 6 cases. In 4 cases there were severe bilateral hearing loss, lack of vestibular function and considerable worsening of stabilograms parameters. In ophthalmologic examination in all the cases there was bilateral symmetrical dystrophy of the retina of various intensification. We concluded that hearing and balance organ examination in Usher syndrome can state accessory diagnostic aspect that might help to distinguish subtypes of the syndrome. In this way audiologic and otoneurologic tests could help to define prognosis of the disease in the individual cases. A necessity of close co-operation of genetics, ophthalmologists and ENT doctors as well as psychologists was stressed.

Adolescent↗

PubMed2002

[Bacterial flora as a potential etiopathogenic factor for nasal polyps].

Nasal polyps develop in patients with disturbed local homeostasis of nasal mucosa. Research of Bernstein and Stoop showed the influence of inflammation of nasal mucosa on growth of nasal polyps. Bacterial and viral infections play significant role in development and intensification of inflammatory and immunological process. Many bacteria produce factors which damage cilia cells, cause dyskinesis of cilia and destroy respiratory epithelium. Disturbed muco-ciliar cleaning permits bacteria to penetrate through mucous layer and facilitate their adhesion and colonization on the cells of respiratory epithelium. Adhesion and successive colonization with bacteria multiplication can lead to inflammatory process. Nose swabs results were different in each examined group. The aim of this work was to define bacterial flora in patients with nasal polyps and in patients after polypectomia and to compare it to bacterial flora in healthy patients. Nose swabs were performed in 51 patients with nasal polyps before polypectomia and additional in 15 patients after polypectomia. 25 healthy medical students were a control group. The patients were divided into two groups: I. patients with nasal eosinophilic polyps, II. patients with nasal neutrophilic polyps. In the group of patients with both neutrophilic and eosinophilic polyps dominating bacterial flora included bacteria which usually are the cause of inflammation. In the group of patients after polypectomia bacterial flora was not different from that which was found in patients with polyps.

Adult↗