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Biomedical subjects

Badreldeen Ahmed

Publications and source records attributed to Badreldeen Ahmed.

8 recordsLinked to original sources

Normal standards for fetal neurobehavioral developments--longitudinal quantification by four-dimensional sonography.

AIM: To construct normal standards for fetal neurobehavioral development using longitudinal observations through all trimesters by four-dimensional sonography. SUBJECT AND METHODS: A group of 100 healthy normal singleton pregnancies were recruited for longitudinal 4D US examinations to evaluate fetal neurodevelopmental parameters between 7 to 40 weeks' gestation. Variables of maternal and fetal characteristics including gestational age, eight fetal movements patterns in the first trimester and 14 parameters of fetal movement and fetal facial expression patterns recorded thereafter for the construction of fetal neurological charts. RESULTS: Measurement of 7 parameters in the first trimester and 11 parameters in the second and third trimesters correlated with gestational age (P<0.05). Those parameters have been followed longitudinally through all trimesters and showed increasing frequency of fetal movements during the first trimester. A tendency towards decreased frequency of facial expressions and movement patterns with increasing gestational age from second to third trimesters has been noticed. CONCLUSION: With 4D sonography, it is possible to quantitatively assess normal neurobehavioral development. There is urgent need for further multicentric studies until a sufficient degree of normative data is available and the predictive validity of the specific relationship between fetal neurobehavior and child developmental outcome is better established.

Brain↗

Routine cervical dilatation during elective cesarean section and its influence on maternal morbidity: a randomized controlled study.

AIM: To determine the effect of routine intraoperative cervical dilatation during elective cesarean section on maternal morbidity. SUBJECTS AND METHODS: Patients with even numbers in the operative elective cesarean section list were included in the study. Of these, every second patient underwent intraoperative cervical dilatation. All participants in the two groups had otherwise similar preoperative care, operative procedures and subsequent clinical care. Blood loss was estimated and maternal infection status was assessed postoperatively by any rise of temperature or wound infection. RESULTS: Of the 131 patients included in the study, 67 underwent cervical dilation and 64 served as controls. There was no significant difference in postoperative hemoglobin, incidence of fever, or wound infection between the two groups. Only two of the cervical dilation group and one control patient developed postoperative fever. A hemoglobin drop of more than 0.5 g/dL was noted in 27 and 26 patients in the cervical dilation and the no dilation groups, respectively (NS). None of the study patients had signs of wound infection. CONCLUSION: Intraoperative cervical dilatation during elective cesarean section did not reduce the risk of postoperative maternal fever, wound infection or change in hemoglobin concentration.

Adult↗

Non-invasive diagnosis of fetal anemia due to maternal red-cell alloimmunization.

OBJECTIVE: To determine the value of measurement of velocity of the middle cerebral artery (MCA) in the prediction of fetal anemia in alloimmunized pregnancies without ultrasound evidence of hydrops and to see if this could replace the invasive techniques in the diagnosis and management of this condition. METHODS: In a prospective cohort study, 65 non-hydropic fetuses with red blood cell alloimmunization were evaluated with ultrasound and Doppler imaging. This study was carried out at Feto Maternal Medicine Unit at Women's Hospital, Hamad Medical Corporation, Doha, Qatar from January 2003 to December 2003. Middle cerebral artery-peak systolic velocity (PSV) was measured. We interfered only if there is a sign of fetal anemia as indicated by changes in blood velocity in MCA using the table designed by Giancarlo Mari or the fetus developed signs of hydrops fetalis. Immediately after delivery, the blood was taken from umbilical cord for full blood count, blood group, bilirubin and antibodies level. Results before first fetal blood sampling (FBS) or delivery were analyzed. RESULTS: Sixty-five patients met the inclusion criteria for the study and were managed. Sixty-three women were alloimmunized with rhesus (Rh)-D antibodies and 2 with anti-C. With the conventional management, all 65 patients undergone amniocentesis to determine bilirubin levels. However, with non-invasive management, 60 women were safely prevented from undergoing invasive testing or invasive procedures. Amniocentesis was performed for only one (1.54%) patient, despite having a normal MCV-PSV which was carried out solely due to the care provider was insisting on this procedure and the result was normal. Planning delivery based on MCA-PSV allowed us to deliver 97% (63/65) of these babies without any signs of severe anemia between 28-38 weeks. Two (3%) of the fetuses were diagnosed as severely anemic with MCA-PSV. In both cases, anemia was confirmed by FBS and intra uterine transfusion was carried out immediately to the test. Only 2 babies were diagnosed anemic after birth and underwent blood transfusion. CONCLUSION: Doppler evaluation of MCA-PSV is effective in the prediction of fetal anemia in red blood cell alloimmunization. Using this technique will reduce the number of invasive procedures needed with the added risks of these procedures with good fetal outcome.

Anemia↗

Female genital mutilation and childbirth.

The practice of female genital mutilation sadly remains to this day, part of the life of many women worldwide. In the Middle East and Africa, it is hard to practice obstetrics and gynecology without some knowledge of the condition. This review is an attempt to discuss the salient points as regards to management of these women during pregnancy and labor.

Circumcision, Female↗

Study of peripheral circulation in non-pregnant, pregnant and pre-eclamptic women using applied potential tomography.

BACKGROUND: Profound changes are known to occur in the cardiovascular system during pregnancy, involving an increase in cardiac output and a fall in peripheral resistance. In some women these adaptations may be inappropriate and this may result in pregnancy-induced hypertension and pre-eclampsia. AIMS AND METHODS: The aims of the study were to evaluate the relatively new, non-invasive technique of applied potential tomography (APT) in measurements of peripheral blood flow, to study peripheral blood flow in a sample of non-pregnant, pregnant and pre-eclamptic women, and to investigate whether the adaptive changes in the peripheral circulation are different in pre-eclampsia compared with normal pregnancy. Applied potential tomography was used to assess peripheral vascular reactivity, by monitoring fluid distribution in calf muscles during postural change. RESULTS: The APT technique was able to detect peripheral vasoconstriction in response to an increase in intramural pressure brought about by passive lowering of the leg (peripheral mechanisms). The peripheral vasoconstriction response was found to be more prominent in woman with pre-eclampsia. CONCLUSIONS: The presence of a local reflex in the lower limb had been postulated and the effect of this reflex on the peripheral circulation could be detected using APT, regardless of how it was initiated. In normal pregnant women this reflex was diminished when compared to non-pregnant women, which might contribute to the reduction in peripheral vascular resistance seen in normal pregnancy. This reflex was defective in pre-eclampsia and this lack of adaptation may be a local reflex contributing to the raised peripheral resistance, which in turn may be a factor in high blood pressure in pre-eclampsia.

Adult↗

Cesarean section on request.

Obstetricians are facing a tide of non-medically indicated requests for cesarean section. Risks and benefits of accepting cesarean section on request are discussed.

Cesarean Section↗