Biomedical subjects
B von Bonsdorff
Publications and source records attributed to B von Bonsdorff.
The introduction of active nephrological therapy at the Fourth Department of Medicine, University of Helsinki.
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[The history of infectious agents; a survey].
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The ecology of Diphyllobothrium latum.
The life cycle of the broad tapeworm Diphyllobothrium latum is discussed. To complete its development from egg to adult worm the parasite has to pass through two obligatory intermediate hosts before invading its final host. At each stage critical ecological parameters have to be encountered, among them oxygen concentration, light intensity and temperature. The first intermediate host, which remained unknown for a long time, is one of many copepod species; the second hosts are fish, notably species belonging to the genera Esox. Perca and Lota. The parasite remains in the latter until eaten by Man and his domesticates. The prerequisites for the parasite's development are precise, and the elimination of only one is sufficient to free an area of infection.
Castle's test (with vitamin B12 and normal gastric juice) in the ileum in patients with genuine and patients with tapeworm pernicious anaemia.
A mixture of vitamin B12 and normal gastric juice, instilled through an intestinal tube into the ileum, produces haematological remission in patients with tapeworm pernicious anaemia. When a similar mixture is administered by mouth, this effect fails to occur. This observation constitutes evidence in favour of the view that Diphyllobothrium latum, attached to the proximal portion (jejunum) of the intestine, absorbs the vitamin B12 contained in the food, thus preventing vitamin bound to the intrinsic factor of the gastric juice from reaching the receptors in the distal portions of the small intestine of the host. In genuine pernicious anaemia, remission results from the administration of vitamin B12+gastric juice both by mouth and into the ileum.