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Biomedical subjects

B d'Hoedt

Publications and source records attributed to B d'Hoedt.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Intralesional therapy of melanoma metastases with recombinant interferon-beta].

In ten patients with metastasizing melanomas, discontinuous intratumoral treatment with recombinant interferon beta (rIFN-beta) was administered into 19 cutaneous or palpable subcutaneous metastases. Among the 16 metastases treated with 5 x 10(6) IU per injection, 8 showed partial or complete remission. No recurrence was observed during the 4-9-month follow-up period. There was no regression in 3 metastases treated with 3 x 10(6) IU rINF-beta per injection. No systemic antineoplastic effects were observed in any of the cases. The IFN-beta serum levels were measurably increased following intratumoral application. Local treatment led to a significant increase in (2'-5')oligoadenylate synthetase in the mononuclear blood cells and in the serum. Side-effects of the treatment were moderate; there was a temporary increase in transaminases, a decrease in thrombocytes and influenza-like symptoms. The results show that IFN-beta has a dose-dependent antitumour effect on malignant melanomas.

Adult↗
PubMed1991

Contribution to the functional surface structure of endosseous implants.

An endosseous implant that should allow osseointegration as well as fixation by connective tissue has been developed. A special surface structure consisting of titanium wire loops on a titanium implant was produced by diffusion bonding. The mechanical properties of this implant are investigated.

Dental Bonding↗
PubMed1989

[The Tübingen implant within the scope of adult orthodontic treatment].

Prior to the replacement of a missing tooth with an implant the adult dentition, orthodontic treatment can be carried out to widen the space mesio-distally, correct the axial inclination of the neighbouring teeth and safeguard the anterior overbite. Implantation is not possible if, as a result of orthodontic treatment the gap cannot be widened to a minimum of at least 6 mm, if the alveolar bone is not thick enough in the vertical dimension or if the implant does not have sufficient space in the oro-vestibular direction.

Adolescent↗
PubMed1989

Ultrasonographic diagnosis of melanoma metastases in liver, gallbladder, and spleen.

Ultrasonographic findings in the liver, gallbladder, and spleen of 42 patients with metastatic melanoma of the skin are described in a retrospective study stressing sonomorphologic results. Liver metastases were detected in 27 (64%) of the patients. Clinically asymptomatic melanoma metastases were found in the gallbladder of three patients and in the spleen of three others. The liver metastases were still in the initial stages in 10 patients, whose survival times averaged 8.4 months. The significance of upper abdominal ultrasonography in assessing the spread of metastasizing malignant melanoma during follow-up is emphasized.

Female↗
PubMed1989

A comparative study of results with various endosseous implant systems.

The results of regular follow-up of various endosseous titanium implant systems are presented together with an overview of the results with Tübingen Frialit aluminum oxide ceramic implants. Using ITI implants, pathological findings for sulcus depth and peri-implant bone degradation were found significantly more frequently than with the other titanium implants. Clinical mobility was present significantly more frequently with TPS implants than with the IMZ system, whereas an increase in the depth of the peri-implant sulcus alone occurred significantly more frequently with the IMZ and ITI than with the TPS implant system. The observation period for Brånemark implants is too short to permit final evaluation. However, pathological findings have not occurred to date.

Dental Implantation, Endosseous↗
PubMed1982

The influence of fine surface structures on the osseo-integration of implants.

The availability of inert materials like dense, pure Al2O3-ceramic or titanium allows the study of purely biomechanical influences of surface modulations or lacune on the osseo-integration of implants at different locations of the skeleton. The discovery of the "load-line-shadow" phenomenon in lacune of dental implants and the observation of the same effect in the grooves of hip sockets (Lindenhof type) indicate the general validity of the rules controlling the remodelling ability of bony tissue. Their application to the problems concerned with load transmission via surfaces which are mainly loaded by shear can contribute to achieve a well defined anchorage of implants.

Aluminum Oxide↗
PubMedDate not supplied

Treatment of peri-implantitis defects with autogenous bone grafts: six-month to 3-year results of a prospective study in 17 patients.

As part of an ongoing prospective study, the treatment of peri-implantitis defects using autogenous bone grafts was evaluated. This present report is based on data from 25 ITI screw implants in 17 patients with progressive peri-implant tissue destruction during the maintenance phase. Treatment of these lesions included raising flaps, removal of the surrounding granulation tissue, and air-polishing of the implant surface. Subsequently, corticocancellous bone grafts or particulate bone were placed into the peri-implant osseous defects, and the flaps were sutured around the cervical segment of the implants, allowing for transmucosal healing. Two of the 25 cases resulted in a negative outcome of the procedure. One of the transplants had to be removed 40 days after augmentation because of flap dehiscence and graft mobility. In another patient, the healing period was uneventful until the re-entry surgery, but when the site was reopened, the total graft volume was resorbed. The primary therapeutic success at re-entry surgery evaluated by intraoperative measurements resulted in a median defect depth reduction of 6.9 to 0.7 mm (P = .001), corresponding to a bone repair of 90%. The change in defect width was 1.9 mm (P = .002, repair 100%). A positive result of the reconstructive therapy has been observed during a re-evaluation time of up to 3 years. Median marginal bone loss was reduced from 6.2 to 2.3 mm after 2 and 3 years, respectively. The median vertical bone resorption of 4.5 mm was completely repaired. The crevicular fluid volume, a parameter of the level of marginal inflammation, along with probing depths and attachment levels, were reduced to a physiologic rate. The implant observation period until the first appearance of the lesion seems to be crucial to the effectiveness of the therapy. Early failures appearing within the first 2 years after implant placement showed a more stable therapeutic result over time.

Alveolar Bone Loss↗
PubMedDate not supplied

The longitudinal clinical effectiveness of ITI solid-screw implants in partially edentulous patients: a 5-year follow-up report.

A total of 114 ITI solid-screw implants was consecutively placed in 55 partially edentulous patients and restored with 68 fixed prostheses. The patients were followed for at least 5 years in a prospective study that focused on implant success and longitudinal reactions of the peri-implant hard and soft tissues. During the study period, 5 implants failed and 15 implants were lost to follow-up, resulting in a cumulative survival rate of 95.3% after 5 years of loading. The success analysis included additional strictly defined events ("first occurrence of marginal bone loss > or = 4 mm," "first occurrence of pocket depth > or = 4 mm," and "first occurrence of crevicular fluid volume > or = 2.5 mm") and resulted in a cumulative 5-year success rate of 89.0%. Median loss of marginal bone, as observed on radiographs, was 0.7 mm between implant placement and prosthetic treatment and 0.5 mm between prosthesis placement and the 5-year evaluation. Compared to the previous year's value, the annual increase in marginal bone loss did not reach a level of statistical significance between 1 and 5 years of function, so that a steady state prevailed. The incidence of lingual-palatal surfaces affected with remarkable plaque deposits increased from 13% after prosthesis placement to 23% after 5 years. Sulcus Bleeding index, probing depth, attachment level, and crevicular fluid volume were used to describe the health of the peri-implant soft tissues. The research parameters remained almost unchanged and indicated a soft tissue response within physiologic levels. Most mechanical complications were experienced during the first year of loading and were related to loosening of occlusal screws, which occurred in 8 (12%) of 68 restorations.

Adolescent↗