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Biomedical subjects

B Zederfeldt

Publications and source records attributed to B Zederfeldt.

At least 55 records · Page 3Linked to original sources
PubMed1988

Impact of long-term relative bowel rest on conditions for colonic surgery.

Collagen content, bursting wall tension, and suture-holding capacity in the proximal and distal colon of the rat were studied after long-term treatment with a low-residue or a standard laboratory chow diet. Collagen content decreased uniformly in both the proximal and distal colon of the low-residue diet group. In addition, the bursting wall tension of the nonoperated proximal colon was reduced, whereas the breaking strength of a newly constructed anastomosis at three different colonic sites was unaffected.

Animals↗
PubMed1988

The postcholecystectomy syndrome: bile ducts as pain trigger zone.

Sixty-five non-icteric patients presumed to have the postcholecystectomy syndrome (PCS) were followed up for 4-13 years after their first endoscopic retrograde cholangiopancreatography (ERCP) examination, which gave normal findings. All patients, however, experienced severe pain on injection of only 1-2 ml of contrast medium over 5-10 sec into the common bile duct (CBD). Thirty-four of the 65 patients were found to have true PCS on long-term follow-up studies, whereas 31 of them had other diseases. A second ERCP also showed normal results, and the injection-related pain was preceded by an abnormal pressure rise in the CBD at manometry. The CBD acted like a pain trigger zone, and the pain reaction might be diagnostic in everyday clinical practice. In conclusion, ultrasonography is an adequate diagnostic method in non-obstructive PCS. Medical treatment is often successful. ERCP and interventional treatment should be reserved for patients with obstructive symptoms and for patients in whom all medical treatment has failed.

Biliary Dyskinesia↗
PubMed1988

Left colon anastomotic healing following colostomy closure. An experimental study on rats.

The impact of colostomy closure on the healing of a left colonic anastomosis performed 4 weeks earlier was studied in rats. Colostomy closure could be safely accomplished but in 3 of 25 rats was followed by faecal obstruction due to narrowing of the primary left colonic anastomosis. After colostomy closure the gain in anastomotic strength was slow and did not exceed the outset value until after 3 weeks. After colostomy closure, accumulation of collagen in the anastomotic region increased earlier than anastomotic strength, indicating delay in collagen maturation.

Anastomosis, Surgical↗
PubMed1988

Healing of anastomoses after obstruction of small intestine.

Anastomotic healing after obstruction of the small intestine was investigated by measurements of development of strength, content of collagen and synthesis of collagen in standardized specimens taken at biopsy of the intestinal wall on both sides of the anastomosis. One hundred and sixteen male Wistar rats were used. Forty-eight rats were used for studies of synthesis of collagen by in vivo labeling with 100 microcuries of tritiated L-proline. Anastomoses performed after two days of obstruction in the ileum had a higher rate of complications than operations performed upon control rats (p less than 0.05). Obstruction of the small intestine resulted in increased content of collagen of the ileal wall as a consequence of increased synthesis of collagen, but this resulted in neither increased capacity to hold suture nor in any differences in development of strength between rats operated upon for obstruction of the small intestine and control rats. Increased turnover of collagen was noted in the vicinity of the anastomoses after obstruction, which might be related to the increased rate of complications found. Rats with complications accumulated more collagen in the intestinal wall after one week compared with rats with obstruction and uncomplicated healing. These rats had persistent obstruction or formation of granuloma, or both.

Anastomosis, Surgical↗
PubMed1987

Collagen metabolism in small intestinal anastomosis.

Collagen metabolism in the small intestinal wall during the first week of anastomotic healing in operated and nonoperated rats was studied. During this period, marked changes in anastomotic strength have been observed. A general and marked increase of collagen synthesis was found throughout the intestine already on the second day. This resulted in increased collagen content. Collagen concentration remained relatively unchanged despite an increase in collagen content as a result of concomitant increase of noncollagenous substances. The previously reported loss of anastomotic strength in the early phase of healing could not be explained by changes in collagen content or metabolism in this study. Cutting of sutures seems to be due to a local process. After 4 days, collagen content increased predominantly in the anastomotic region. It correlated well to the previously observed increase of anastomotic strength.

Animals↗
PubMed1987

Parathyroid lipoadenoma: a rare cause of primary hyperparathyroidism. Case report.

Three patients with lipoadenoma of the parathyroid gland are reported. This rare tumour was encountered at surgical exploration for primary hyperparathyroidism in two patients and as an incidental finding at autopsy in the third patient. In the 2 operated patients the lipoadenoma was the cause of primary hyperparathyroidism and they were both cured by extirpation of the tumour. In the autopsy case there was no evidence of excessive parathyroid hormonal activity. The dominating stromal component of all three cases was abundant adult adipose tissue interspersed with epithelial trabeculae of mainly chief cells.

Adenoma↗
PubMed1986

Mechanical and biochemical alterations in the intestinal wall adjacent to an anastomosis.

Mechanical strength of the small intestinal wall 3.5 mm from an anastomosis was studied during the first week of healing and correlated to alterations in collagen content. The mechanical properties of the small intestinal wall 3.5 mm from the primary anastomosis remained constant during the first 3 days of healing. A previously observed decrease in suture-holding capacity of the small intestinal wall thus is a very local process extending less than 3.5 mm from the transection line. After 1 week of healing, the increase of suture-holding capacity correlated well with the increase in collagen content of the bowel wall.

Animals↗
PubMed1986

Juxtapapillary choledochoduodenal fistula following choledochal exploration and diagnosed by early duodenoscopy.

In 86 patients who had undergone common-duct exploration at surgery for benign biliary disease, duodenoscopy was performed within 4 weeks after the operation. Choledochoduodenal fistula, apparently iatrogenic, was then found in eight patients (9.3%). All eight were among the 35 patients in whom a rigid probe had been passed to the duodenum, giving a fistula incidence of 23% in this group. Four of the eight patients consented to repeat duodenoscopy, which showed healing of fistula within a year in three cases. No patient with choledochoduodenal fistula experienced postoperative biliary symptoms.

Adult↗
PubMed1985

Beneficial effect on intestinal anastomoses of S-2441, a synthetic kallikrein-kinin antagonist. Experimental studies in the rat.

The effects of two protease inhibitors on breaking strength of an intestinal anastomosis were studied. The inhibitors tested were aprotinin and S-2441, a synthetic triple-peptide kallikrein-kinin antagonist. Rats were subjected to an end-to-end anastomosis in the small intestine. The breaking strength, or suture-holding capacity, was measured immediately after suture and after 24 hours. The loss of mechanical strength found in untreated rats was substantially, but not fully, prevented by S-2441. Aprotinin in the dose given was not effective.

Animals↗
PubMed1985

Changes in collagen content of the small intestinal wall after anastomosis.

Collagen content of small intestinal anastomosis in the rat was investigated in relation to previously reported changes in suture-holding capacity. The decrease in suture-holding capacity during the first 3 days previously observed, the inflammatory phase, did not correlate with collagen content during this period. However, the increase in suture-holding capacity from the third to the seventh days, the phase of fibroplasia, correlated well with an increased collagen content in the intestinal wall in both the ileum and jejunum. Anastomotic strength and collagen content correlated well after the third day. Deposition of collagen, not only in the wound but also in the intestinal wall and within the loop of the suture during the phase of fibroplasia, is the likely explanation for the rapid increase of suture-holding capacity during this period.

Animals↗
PubMed1985

Effect of diverting colostomy on collagen metabolism in the colonic wall. Studies in the rat.

The effect of total bowel rest by colostomy on collagen metabolism was studied. Fecal diversion led to a marked decrease of collagen and protein synthesis in the excluded colon. These changes were accompanied by a decrease in the amount of collagen and noncollagenous components. In the colonic part proximal to the colostomy site, a less marked decrease in collagen content was observed. It was concluded that stimulation of intraluminal bulk might be important as a regulating factor for collagen turnover. It remains to be determined if the observed changes in collagen metabolism affect colonic healing.

Animals↗
PubMed1985

Effect of diverting colostomy on breaking strength of anastomoses after resection of the left side of the colon. Studies in the rat.

In the present investigation, the effect of a proximal diverting colostomy on suture holding capacity and on anastomotic strength of the excluded left colon was studied. Suture holding capacity was increased 7 days after fecal diversion. Anastomotic strength development, however, was significantly delayed. These differences were accompanied by a diminished collagen response in the anastomotic region after fecal diversion. This might suggest impairment of healing in the excluded colon. The gross appearance of the anastomoses would, however, indicate that increased collagen formation and greater strength development in animals without colostomy is a result of more complicated healing.

Animals↗
PubMed1985

Influence of intraperitoneal Escherichia coli with septicemia on the healing of colonic anastomoses and skin wounds. An experimental study in the rat.

In rats a standardized left colonic resection was performed and colonic continuity restored by an end-to-end anastomosis in one layer. The rats were subjected to an LD50 septic challenge by intraperitoneal injection of live Escherichia coli pre- or postoperatively. Controls received saline in a corresponding manner. Groups of animals were sacrificed on the 3rd or 7th postoperative day. The breaking strengths of the anastomosis and of the skin wound were measured. The collagen content of the anastomotic segments was analyzed. There were no differences in anastomotic or skin wound strength between septic animals and controls. Collagen content was unaffected. Wound healing was not influenced by sepsis in this model.

Animals↗
PubMed1985

Suture technique and early breaking strength of intestinal anastomoses and laparotomy wounds.

The influence of different suture techniques on early fascial and intestinal breaking strength was studied in rats subjected to either colonic anastomosis or median laparotomy only. Interrupted sutures were used throughout. The sutures were inserted either 3 mm or 1.5 mm from the wound edges. The breaking strength with the sutures in situ, i.e. the suture holding capacity, was measured either immediately or 48 hours after their insertion. The breaking strength of the sutured fascia, but not that of the colon, was higher when sutures were inserted at the longer distance from the wound edges. Postoperative decrease of suture holding capacity occurred in both colon and fascia, but only when the sutures had been placed near the incision.

Animals↗
PubMed1985

Beneficial effect of proteinase inhibitors on early breaking strength of intestinal anastomoses.

Rats were subjected to end-to-end anastomosis of the small intestine. The breaking strength was measured in different groups immediately after suture and after 24, 72 and 120 h. Tiopronin (Thiola), soya-bean trypsin inhibitor (STI), or saline solution, was given by continuous intravenous infusion during the test periods. In the saline groups there was a marked decrease in breaking strength at 24 and 72 h. Most of the strength was restored at 120 h. The metalloproteinase inhibitor tiopronin, which in a previous study had diminished the decrease in breaking strength at 24 h, was without effect at 72 h. Rats given STI, which is a group-specific serine proteinase inhibitor, had substantially higher values of breaking strength than saline-treated controls at 24 and 72 h. At 120 h no difference was found. Since the postoperative decrease in breaking strength could be attenuated by proteinase inhibitors, it seems to be due to proteinase activities. STI-treatment did not impair subsequent gain in mechanical strength during the fibroplasia period.

Amino Acids, Sulfur↗