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Biomedical subjects

B Wood

Publications and source records attributed to B Wood.

At least 55 records · Page 3Linked to original sources
PubMed1998

Taxonomic and functional implications of mandibular scaling in early hominins.

Body mass estimates for fossil hominin taxa can be obtained from suitable postcranial and cranial variables. However, the nature of the taphonomic processes that winnow the mammalian fossil record are such that these data are usually only available for the minority of the specimens that comprise the hypodigm of a species. This study has investigated the link between species mean body mass and the height and width of the mandibular corpus in a core sample of 23 species of extant simians. The slopes of the least-squares regressions for the whole sample and for the hominoid subset are similar. However, the intercepts differ so that for a given body mass, a hominoid will generally have a smaller mandible than a generalized simian. The same mandibular measurements were taken on 75 early hominin mandibles assigned to eight species groups. When mandibular corpus height- and width-derived estimates of body mass for the fossil taxa were compared with available postcranial and cranial-derived body mass estimates, the eight early hominin species sort into four groups. The first, which includes A. afarensis and A. africanus, has mandibles which follow a "generalized simian" scaling relationship. The second group, which comprises the two "robust" australopithecine species, P. boisei and P. robustus, has mandibles which scale with body mass as if they are "super-simians," for they have substantially larger mandibles than a simian with the same body mass. The two "early Homo" species, H. habilis sensu stricto and H. rudolfensis, make up the third group. It has mandibular scaling relationships that are intermediate between that of the comparative simian sample and that of the hominoid subsample. The last of the four groups comprises H. ergaster and H. erectus; their mandibles scale with body mass as if they were hominoids, so that of the four groups they have the smallest mandibles per unit body mass. These results are related to comparable information about relative tooth size. Their relevance for attempts to interpret the dietary adaptations of early hominins are explored.

Animals↗
PubMed1998

A technique for establishing the identity of 'isolated' fossil hominin limb bones.

Associated skeletons, which are specimens preserving more than one body part from the same individual, are especially important for taxonomic and functional analyses. This study concentrates on the subset of associated skeletons which preserve the reciprocal surfaces of a joint. It uses laser scanning to explore whether the shapes of the reciprocal surfaces of a joint of an individual are significantly more congruent than the surfaces of randomly-matched pairings taken from the same species. Laser scanning was used to capture the distal articular surface of the left tibia of OH35 and the trochlear articular surface of the talus of OH8, both from Bed I, Olduvai Gorge, Tanzania. The degree of congruency between those articular surfaces was tested against the congruency of the talocrural joint of AL 288-1 (Australopithecus afarensis), and the congruency of both associated and randomly-matched talocrural joints of modern humans, chimpanzees and gorillas. The results suggest that OH35 and OH8 do not come from the same individual and may not come from the same species. Although this analysis leaves open the taxonomic affinity of OH35, it demonstrates the potential of laser scanning for capturing 3D data in palaeoanthropology. It also demonstrates the potential for using the relative congruency of reciprocal joint surfaces as a test of the likelihood that isolated limb bones are components of a single individual.

Animals↗
PubMed1998

Teaching the clinical interpretation of peripheral blood smears to a second-year medical school class using the PeripheralBlood-Tutor computer program.

The interpretation of peripheral blood smears has an important role in the diagnosis of hematologic diseases and is, therefore, part of the education of physicians and technologists. We describe a computer program, PeripheralBlood-Tutor (Lippincott-Raven, Philadelphia, Pa), that teaches the morphologic features of normal and abnormal peripheral blood smears; we also describe the evaluation of the effectiveness of the program in 133 second-year medical students who were required to use the program in their hematology course. The version of the PeripheralBlood-Tutor used in the study had 2 distinct but equivalent 20-question examinations; one examination, the pretest, was taken before the students viewed the contents of the program, and the other examination, the posttest, was taken after completing the program. The mean score on the pretest was 61% (SD, 14%), the mean on the posttest was 91% (SD, 10%), and the improvement was significant. In addition, 4 questions about peripheral blood smears, which were based on printed images, were administered at the end of the hematology course. The students scored an average of 2.75 (SD, 0.86), and a positive correlation was found between these scores and the scores on the Tutor posttest. The results of the study suggest that PeripheralBlood-Tutor is feasible to implement, and it helps students learn to interpret peripheral blood smears. The use of PeripheralBlood-Tutor is now a requirement in the medical school curriculum, the medical technology program, and the pathology residency at the University of Washington, Seattle.

Blood Cell Count↗
PubMed1998

Pellagra in a woman using alternative remedies.

A young woman presented with pellagra. Dietary intake of niacin was in excess of recommended guidelines. She had a low body mass index and was taking a number of alternative remedies. Resolution was rapid with oral nicotinic acid and discontinuation of the remedies.

Adult↗
PubMed1998

The process of intimacy: similarity, understanding and gender.

This study examined gender and three aspects of marital intimacy using a method to establish both objective and subjective indices of intimacy. Fifty couples answered the Personal Assessment of Intimate Relationships (Schaefer & Olson, 1981) twice: once as a self-report and once to respond as they predicted their spouses would answer. Couples who were less accurate in predicting each other's responses also diverged in their experience of intimacy and reported lower intimacy. Results suggest that high intimacy is based on both understanding and similarity of intimate experience. Women reported significantly higher levels of intimacy and were also better than men in predicting their partners' feelings. These findings suggest that women may be more attuned to intimacy or that definitions and assessment of intimacy are gender biased or both.

Female↗
PubMed1998

Salivary cortisol profiles in chronic fatigue syndrome.

Salivary cortisol profiles (hourly sampling over a 16-hour period) of 10 patients with chronic fatigue syndrome (CFS) but without concurrent depressive disorder were compared with those of 10 healthy volunteers matched for age, sex and menstrual cycle. The mean saliva cortisol concentration over the 16-hour period was slightly but significantly greater in the patients than the controls (p < 0.05). These findings are at variance with earlier reports that CFS is a hypocortisolaemic state and suggest that in CFS the symptom of fatigue is not caused by hypocortisolaemia.

Adolescent↗
PubMed1998

Infrared microspectroscopy and artificial neural networks in the diagnosis of cervical cancer.

Infrared spectra of 88 normal and 32 abnormal (mild to severe dysplasia) cervical smear samples were used as a databank to investigate the usefulness of artificial neural networks (ANN) in the diagnosis of cervical smears. The spectra were first reduced, using principal component analysis (PCA), to seven wavenumber components that are the major contributors to the variance. A number of different ANN architectures were investigated that could differentiate between normal and abnormal cervical smears. Although the ANNs were trained to differentiate only normal from abnormal smears, the results using an independent test data set indicated that within the abnormal category mild dysplasia could be distinguished from severe dysplasia. The results using this restricted data set indicate that neural networks coupled to infrared microspectroscopy could provide an alternative automated means of screening for cervical cancer.

Female↗
PubMed1997

Potent topical steroid in a Chinese herbal cream.

Steroids have been discovered previously in oral "herbal" preparations. Using liquid chromatography, we have now confirmed the presence of the potent topical steroid, clobetasol proprionate, in a Chinese herbal cream.

Administration, Topical↗
PubMed1997

Nosocomial Trichophyton tonsurans in a long stay ward.

AIMS: To document a nosocomial outbreak of Trichophyton tonsurans infection in a long stay ward. METHOD: Retrospective review of mycology cultures taken from patients and staff during 1993-5 and clinical examination of both patients and staff. RESULTS: Thirty-three mycology samples from 13 patients and staff, cultured T tonsurans during the period 1993-5. Twenty-two patients and staff were examined; 4 had mycology confirmed T tonsurans (2 scalp, 2 fingernail). Treatment with terbinafine 250 mg/day for 2 months resulted in clinical clearance (only 1 positive culture in 16 months follow-up). SUMMARY: T tonsurans is emerging as an important pathogen which may cause nosocomial infections.

Adult↗
PubMed1997

Contact dermatitis from cetostearyl alcohol.

Emulsifiers are an uncommon cause of allergic contact dermatitis. Five cases of allergic contact dermatitis to cetostearyl alcohol are presented. In all five cases, multiple positive reactions to other allergens were present, usually topical corticosteroid creams.

Adult↗
PubMed1997

The economic impact of high-risk pregnancies.

To compare the costs of prenatal care, labor and delivery, and postnatal care of 775 high-risk (HR) pregnancies with costs of 2,825 low-risk pregnancies, data were collected from retrospective chart review and computerized financial records of infants and mothers. Claims paid to providers, hospitals, and ancillary services were the direct medical costs of care for Sentara Health Plan. The total prenatal, labor and delivery, and postnatal costs were more than 6 million dollars and 3.5 million dollars for premature and term babies, respectively. Postnatal and total costs were related inversely to gestational ages and birth weights and directly related to length of stay. The data indicate the substantially increased cost of identified HR pregnancies. The gestational age and birth weight correlate with postnatal and total costs.

Adolescent↗
PubMed1996

Hominid palaeobiology: have studies of comparative development come of age?

It is 70 years since Adolf Schultz urged his colleagues to consider how studies of primate growth and development could help them interpret the course of human evolution. This paper considers the evolutionary context of comparative growth studies. It compares and contrasts aspects of the ontogeny of living modern humans and chimpanzees, and considers whether relatively simple models of heterochronic change can account for the modifications which have taken place during the course of human evolutionary history.

Animals↗