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Biomedical subjects

B Wocial

Publications and source records attributed to B Wocial.

At least 127 records · Page 7Linked to original sources
PubMed1978

Urinary excretion of catecholamines and their metabolites in patients with renovascular hypertension.

Urinary excretion of catecholamines, vanillylmandelic acid, and methoxycatecholamines was studied in 50 patients with renovascular hypertension. The urinary excretion of noradrenaline was increased in patients with elevated peripheral plasma renin activity and in those with elevated renal vein renin ratio in comparison with the patients with normal plasma renin activity. The urinary excretion of dopamine was diminished and vanillylmandelic acid increased in the entire group of patients with renovascular hypertension. In the investigated group, following sodium restriction, the mean urinary excretion of noradrenaline increased while dopamine excretion decreased. These results suggest that the increased sympathetic activity may play a role in the pathogenesis of renovascular hypertension.

Adolescent↗
PubMed1977

Renin release and autoregulation of blood flow in a new model of non-filtering non-transporting kidney.

1. A recently developed model of a non-filtering, non-transporting dog kidney, obtained by an in situ filling of tubules with low-viscosity oil, was applied for studies of renin release and autoregulation of renal blood flow (RBF). 2. Renal blood flow was partially autoregulated after oil blockade of tubules, as indicated by a mean autoregulation index (Semple-de Wardener (1959) of 0-5. This was comparable to autoregulation of the stop-flow kidney (index 0-6) and contrasted with abolition of autoregulation after hypertonic mannitol loading at stop-flow conditions (index 1-1). 3. The aortic construction at a suprarenal level, which decreased renal perfusion pressure of the oil-blocked kidney 35 +/- (S.E. of mean) 6 mmHg, produced an increase in arterial plasma renin activity of 1-8 +/- 0-1 ng. ml.-1 (P less than 0-02). Renin secretion rate decreased 33 to 70 ng.min-1 in three dogs in which renal perfusion pressure was reduced to 60--66 mmHg, but increased 110 +/- 41 ng.min-1 when pressure reductions were kept within the renal blood flow autoregulation range (n=8, P less than 0-025). 4. These results suggest that signals from the tubular receptor (macula densa) are not necessary for stimulation of renin release or autoregulation of renal blood flow.

Animals↗
PubMed1977

Metabolic and hormonal studies in patients with essential hypertension.

In 106 patients with essential hypertension and different plasma renin activity several hormonal and metabolic factors were studied: urinary excretion of catecholamines, blood levels of cholesterol and triglycerides, levels of glycaemia and insulinaemia after glucose load and plasma fibrinolytic activity. The plasma renin activity in 46.2 percent of patients was normal, whereas in 25.5 percent it was low, and in 28.3 percent it was high. In patients with high plasma renin activity the excretion of noradrenaline and adrenaline was relatively high while that of dopamine was low. Significantly lower triglyceride levels were found in patients with low plasma renin activity in comparison with those with high and normal plasma renin activity. There was also a statistically significant difference in the euglobulin lysis time which was shorter in patients with low and longest in patients with normal plasma renin activity. The results of the study show that patients with different plasma renin activity may also differ in some hormonal and metabolic values.

Adult↗