Biomedical subjects
B Winblad
Publications and source records attributed to B Winblad.
A scanning electron microscope study of the glomerular epithelial cells in alloxan diabetic rats.
The glomerular epithelial cells in control and alloxan diabetic rats were studied by scanning electron microscopy. The changes observed in the epithelial cells were mainly localized to the terminal foot processes. In one long-term (12 months) diabetic rat a complete fusion of these processes was observed. Rats with long-term alloxan diabetes had generally more advanced glomerular epithelial lesions than age-matched control animals. The glomeruli of rats diabetic for only one month did not appear to differ from those of corresponding controls.
Bone marrow examination as a diagnostic tool in carcinoma of the prostate.
155 patients with a newly discovered carcinoma of the prostate were investigated for the presence of bone metastases. Straight X-ray (conventional X-ray) revealed such secondary in 38 cases and bone marrow examination in 20. Three patients with a normal X-ray picture nevertheless showed cancer cells on bone marrow examination. The authors consider bone marrow examination as a valuable complement to the routine invedtigation of the patients with carcinoma of the prostate.
Vascular and morphological changes in the urinary bladder wall after irradiation.
Twelve adult rabbits were used to study radiation-induced changes in the urinary bladder by angiographic, microangiographic, light microscopic and scanning electron microscopic methods. Angiographic, microangiographic and light microscopy examinations were performed on 2 animals in which the urinary bladders were not irradiated and on 4 animals in which parts of the bladders received high radiation doses of 60Co. The bladders irradiated in this manner exhibited advanced changes within a shorter time after irradiation than those in an earlier study. In this study a lower dose of irradiation was given over the entire bladder. Otherwise, the radiation changes were similar. Light and scanning electron microscopic studies were carried out on 2 normal and 4 irradiated bladders. In the latter, atrophy of the mucosa, epithelial desquamation, cellular atypisms and ulcerations were observed.
Periapical destructions caused by experimental pulpal inoculation of Streptococcus mutans in rats.
The development of pulpal and periapical changes in rat molars was studied after inoculation of Streptococcus mutans (GS-5) into the pulp chamber. Before injection into the pulp Streptococcus mutans was cultured on a special collagen substrate and "trained" to break down collagen. The destruction of the alveolar bone periapically could be demonstrated both roentgenologically and histopathologically. Large numbers of inflammatory cells in the pulp chamber and the periapical area, as well as carious dentin, were present. The pulpally inoculated bacteria could also be recovered from the systemic blood. The identity between the pulpally inoculated bacteria and the bacteria recovered from the blood was proved by gel precipitation.
Lowered monoamine oxidase activity in brains from alcoholic suicides.
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Spread of tuberculosis from obstructed and non-obstructed upper urinary tract.
As part of an experimental study of the spread of urogenital tuberculosis, male guinea pigs were inoculated with tubercle bacilli (H37Rv) in the upper part of the ureter. Half of the animals were prepared by ligature of the ureter below the injection site prior to inoculation. Spread of the infection to the lower urinary tract and the genitalia occurred whether the ureter was intact or ligated. It is concluded that lymphatic spread is possible and seems to be more common than urinary (canalicular) spread.
Experimental renal candidiasis in mice and guinea pigs.
As a part of an experimental study of the spread of urogenital infections, male guinea pigs and mice were intravenously injected with a sublethal dose of Candida albicans in a long-time experiment. The kidney was the organ of maximum infection. Spread in the kidney was observed from the cortical and glomerular capillaries, where the injected yeast cells first lodged, but after pseudomycelial transformation penetrated into the Bowman's space and into the lumen of the tubuli. Guinea pigs recovered from the infection. In mice the renal candidiasis progressed and two types of the disease could be distinguished: an acute type with cortical abscesses and a chronic type with partly necrotic tips of the pyramids and adhering fungal masses in the pelves. A similar picture has been observed in man. The pathogenesis of renal candidiasis seems to resemble that of renal tuberculosis.
Experimental male genital tuberculosis-appraisal of protective value of BCG vaccination.
As part of an experimental study of the spread of urogenital tuberculosis, the development of tuberculous infection was compared in vaccinated and non-vaccinated guinea pigs after challenge with Mycobacterium tuberculosis strain H37Rv into the seminal vesicle. The animals were saccrified 35 days after challenge. Morphological observations indicate that tuberculous infection in an immunized animal is retarded, but spreads by the same routes as in an nonimmunized animal. On microbial enumeration significantly lower numbers of organisms were recovered from the inoculated seminal vesicle and regional iliac lymph nodes of the BCG-vaccinated guinea pigs.
Male genital tuberculosis-the possibility of lymphatic spread. A case report.
A 52-year old man with recurrent, persistent tuberculosis developed a tuberculous epididymitis. No inflammatory changes were found in the ductus deferens. It is likely that spread of infection from the prostate to the epididymis occurred via the lymphatics in the funiculus spermaticus.
Scanning electron microscopic study of virulent and avirulent colonies of Neisseria gonorrhoeae.
A preparation procedure for scanning electron microscopy was developed by which gononcoccal colonies can be studied directly on the agar surface. After glutaraldehyde fixation directly in petri dishes, small agar pieces were cut out and dehydrated stepwise in increasing concentrations of ethanol. The blocks were thereafter transferred to a critical-point drying apparatus, via steps of increased gradients up to 100% amyl acetate. By this method five different gonococcal colony types could be distinguished analogous to light microscopic observations made by others. At higher magnifications an abundance of intercellular strands was found between the cells in virulent type 1 and 2 colonies, but not in the avirulent types 3 through 5. These strands seemed to anchor the cells to each other and to the agar surface. The presence of such structures probably explains the highly convex surface of virulent colonies and explains why colonies of avirulent strains exhibit a radial extension and a flat upper surface. The nature of these filamentous intercellular strands is discussed.
Letter: Brain-levels of monoamine oxidase in depression.
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Vasovasostomy suture technique. An experimental study in the dog.
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Heart failure as complication of lithium treatment. Preliminary report of a fatal case.
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Grave lithium intoxication with fatal outcome.
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Huntington's chorea: pathology and brain amines.
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Determination of 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and homovanillic acid in brain tissue from an autopsy material.
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Primary localized amyloidosis of the bladder.
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