Search PubMed⌕ Search

Biomedical subjects

B Werner

Publications and source records attributed to B Werner.

At least 19 recordsLinked to original sources
PubMed1979

Hepatitis A and Indian childhood cirrhosis.

Antibody to hepatitis A virus (anti-HAV) was found in 50% of patients with Indian childhood cirrhosis; this was not significantly different from the prevalence of anti-HAV in age- and sex-matched controls.

Antibodies, Viral↗
PubMed1978

[Postgastrectomy syndromes. Development of the aspects in past and present (author's transl)].

After gastric operations about 20 to 30% of all patients complain of an abundance of postoperative gastrointestinal and vasomotor complaints. Research into these "postgastrectomy syndromes" is carried out periodically. In the beginning of this century concepts as precipitated evacuation, dumping stomach, too narrow or too wide anastomosis predominate. In the thirties the subdivision into a so-called early and late dumping syndrome follows. The description and treatment of the afferent loop syndrome in the middle of this century suggest the introduction of functional factors into the explanation of the postgastrectomy syndromes. Next comes the recognition of the pathophysiological significance of the regurgitated duodenal contents into the operated stomach. The endoscopic biopsy gives a broad morphological basis. The postoperative alcaline reflux gastritis temporarily ends the development.

Bile↗
PubMed1978

Inter- and intra-individual variation of carbon monoxide production in young healthy males.

Duplicate studies of endogenous CO production (Vco) were performed in three groups of young healthy males. In group A (eleven subjects) Vco studies were performed with an interval of approximately 1 week. In group B (ten subjects) duplicate studies were done on the same day and in group C (ten subjects) duplicate studies were also done on the same day but with the subjects strictly resting between determinations. The error of the single determination estimated from duplicate measurements (formula: see text) was +/-4.3 mumol/mmol TBH.day (TBH = total body haem) in group A and +/-3.7 and +/-1.0 in group B and C, respectively. Thus the intra-individual variation in Vco was considerably diminished when the duplicate determinations were performed with the subjects strictly resting between determinations. A possible explanation for this might be less variation in blood flow or metabolic processes in tissues engaged in haem breakdown in the resting group compared with the other groups.

Adult↗
PubMed1978

[Duodenal cancer. A clinical-pathological study].

Seven primary carcinomas of the duodenum were observed from 1973 to 1976 at the University Hospital Hamburg; four in females and three in males with an age between 32 and 69 years of age. The interval between the first symptoms (epigastric pain, jaundice, pruritus, diarrhea, and loss of weight) and surgical therapy (duodeno-pancreatectomy) averaged four months. All carcinomas were resected radically from the macroscopic (intraoperative) aspect as well as from the histological findings. Local tumour recurrences which proved fatal occurred in five patients within nine to twenty-one months. One patient died of peritonitis and another of pancreatitis. The diagnostic mode has been changed since the introduction of endoscopy and retrograde cholangio-pancreaticography (ERCP). The consistent inclusion of the duodenum in routine gastroscopy leads to the hope that more carcinomas of the duodenum can be detected early.

Adult↗
PubMed1978

[Radiologically detectable modifications in the cartilaginous parts of the first pair of ribs in connection with age, sex and the cartilaginous part of the other ribs (author's transl)].

2154 thorax radiograms of 1099 male and 1055 female patients with transformations of the costal cartilage were analysed and statistically evaluated in dependence on age. The calcification of the cartilage parts of the first rib was observed on both sides in the same way and concerning the frequency there were no sex conditioned differences. In the age group between 35 and 45 years more than 95% calcifications have been demonstrated. Men show more frequently advanced stages and types of calcification than women. In complete or heavy calcified cartilage zones disconnections in form of splitted parts without calcium have been observed. The lower cartilage skirt is regarded as the localization of the beginning of calcification. The other costal cartilages will be calcified later and less rapidly than the first costal cartilage. Significant differences of type and localization of the calcification were found between men and women. Physiological processes of ageing and mechanical stress as the prevailing calcification-causing factors are discussed.

Adolescent↗
PubMed1977

Experimental carcinogenesis in the resected colon of the rat.

Until now, carcinoma of the large intestine resected previously for benign disease has not been published. However an increasing number of patients resected for Crohn's disease, diverticulitis or trauma may reach nowadays a high lifespan. On the other hand, it is known that the gastroenteral anastomosis is predisposed to cancer development. In this study, the question of whether the large intestine following colotomy or ileotransversostomy is sensitive to carcinogenesis is examined. Male Wistar rats, subjected to colotomy or resection and ileotransversostomy, were treated weekly by subcutaneous injection of 1,2-dimethylhydrazine (12 mg/kg body weight) for seven weeks. The animals were killed 54 weeks after the first injection. At autopsy, 21 out of 29 operated rats had developed adenocarcinomas of the remaining colon. Intact control animals had the same incidence of malignant degeneration of the large bowel. When the anastomosis is chronically irritated by inflammation or by formation of a diverticulum, development, of carcinoma near the stoma was observed. This was the case in three rats of 28 animals. The results demonstrate that the resected colon of the rat is not more sensitive to experimental carcinogenesis than the intact one.

Adenocarcinoma↗
PubMed1977

[Cholecystectomy and experimental coloncarcinoma (author's transl)].

The influence of cholecystectomy on the development of carcinoma of the colon is investigated. The experimental results show a significant high rate of carcinoma of the colon induced by subcutaneous injection of 1,2-Dimethylhydrazin (DMH) in the mouse after cholecystectomy. After 10 weekly injections of 15 mg/kg DMH 70% of the animals with cholecystectomy developed carcinoma. Only 16% of the mice with similar treatment but without cholecystectomy had carcinoma. The cocarcinogenic effect of cholecystectomy is assumed to be due to the increased production of secondary bile salts by the colonic bacteria and the lacking of the resorptive function of the gall bladder for some carcinogenic substances passing through the liver. The background of this experimental studies is the clinical findings that 10% of patients with carcinoma of the large bowels had a cholecystectomy previously.

Adenocarcinoma↗
PubMed1977

[The diagnosis of traumatic haemobilia and bilhaemia (author's transl)].

A case of bile passage into the portal vein (bilhaemia) and two cases of haemobilia are reported. The former is a hitherto undescribed complication of liver injury, in the reported case first noted two weeks after trauma. Serum-bilirubin concentration was 560 mg/l (958 mumol/l). Bilhaemia or haemobilia may occur when a fistula has been formed between the bile duct system and the circulatory system, depending on pressure differences between the two. The diagnosis and exact localisation of bilhaemia or haemobilia can be made by endoscopic retrograde cholangiography, a useful complementary test to selective angiography.

Adolescent↗
PubMed1977

Cholecystectomy and carcinoma of the colon. An experimental study.

The influence of cholecystectomy on the development of carcinoma of the colon is investigated. The experimental results show a significantly increased rate of carcinoma of the colon induced by subcutaneous injection of 1,2-Dimethylhydrazin (DMH) in the mouse after cholecystectomy. After 10 weekly injections of 15 mg/kg DMH, 70% of the animals with cholecystectomy developed carcinoma. Only 16% of the mice with similar treatment but without cholecystectomy had carcinoma. The cocarcinogenic effect of cholecystectomy is assumed to be due to the increased production of secondary bile salts by the colonic bacteria and the lacking of the resorptive function of the gallbladder for some carcinogenic substances passing through the liver. The background of this experimental studies are the clinical findings that 10% of patients with carcinoma of the large bowel had previous cholecystectomy.

Animals↗
PubMed1977

New technique for endoscopic treatment of bleeding gastric ulcer.

In two patients with bleeding gastric ulcer hemorrhage could be stopped by submucous infiltration around the lesion without any complication. This simple method using a selfconstructed needle seems to guarantee good results especially in bleeding little arteries. Infiltration was performed with a 1.5% solution of Aethoxysklerol (Kreussler, Wiesbaden-Biebrich) using 3-5 ml totally for treatment.

Adult↗
PubMed1977

A case of severe compression of the coeliac artery.

A man, aged 42 years, presented as an emergency with a history of stabbing upper abdominal pain, nausea and diarrhoea of two weeks' duration. Apart from abnormal transaminase and alkaline phosphatase values, the routine clinical and laboratory examinations did not reveal any abnormality. As the abdominal pain increased in severity, particularly in association with eating, and projectile vomiting supervened, aortography was carried out and showed severe stenosis of the coeliac axis, involving about 1 cm of the artery. At operation a thick fibrous band, which originated from the median arcuate diaphragm, was seen to constrict the point of origin of the artery and to compress the vessel against the aorta. The band was divided, whereupon the coeliac artery immediately showed strong pulsations and adequate filling. Microscopic examination of the fibrous band revealed, among other structures, those characteristic of a ganglion. The symptoms disappeared after operation.

Adult↗