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Biomedical subjects

B Weil

Publications and source records attributed to B Weil.

At least 91 records · Page 5Linked to original sources
PubMed1975

A vascular permeability factor in lymphocyte culture supernants from patients with nephrotic syndrome. II. Pharmacological and physicochemical properties.

Pharmacological properties of the "Skin Reactive Factor" demonstrated in nephrotic patients are similar to guinea-pig Skin Reactive Factor. This biological activity is not antagonized by anti-histaminic and anti-serotonin drugs. It is inhibited by meclofenamate and pyridinolcanbamate. It is enhanced by diethyldithiocarbamate and normal human serum. According to this results it could be an activator of the kinin system. Biochemical studies indicate that it is a pepsin destroyed protein, unaffected by Rnase and Dnase. Its electrophoretic mobility is that of an albumin or an alpha1 globulin.

Blood Proteins↗
PubMed1975

A vascular permeability factor elaborated from lymphocytes. I. Demonstration in patients with nephrotic syndrome.

P.H.A. and Concanavalin A stimulated lymphocytes culture supernatants were comparatively studied in 23 volontary normals and in 46 patients with nephrotic syndrome. Intradermal injections to guinea-pig demonstrated a permeability increasing and pro-inflammatory factor. Vascular permeability (immediate reaction) is determinated by blue Evans technique. Delayed reaction is assesed by the cutaneous inflammatory process (erythema, induration); pathologically it is defined as polymorphonuclear and mononuclear infiltration. Differences are highly significant between nephrotic patients and normal subjects. This biological activity is not observed with control supernatants (medium plus normal human serum and P.H.A. or Conca A). Positive results were also found with M.E.M. eagle culture supernatants of nephrotic stimulated lymphocytes. To date lymphokines have been studied especially in animals. In human, they have been found only after concentration. Variations in lymphokine production may be present in some pathologic states.

Animals↗
PubMed1975

Lymphokine 'skin reactive factor' (SRF) and the nephrotic syndrome.

Lymphocytes from N.S. patients, in culture and stimulated by PHA or Con A, release a lymphokine which increases vascular permeability; this factor is not present in normal subject and in control supernatants. Pharmacological and biological properties of this factor are similar to the guinea pig S.R.F. (PICK, TURK, MAILLARD). Modifications observed with meclofenamate, DTTC and addition of N.H.S. suggest that it could be an activator of the kinin system. Physicochemical studies show that it is a protein migrating as albumin. We have also recently demonstrated (unpublished data) the relationship of this factor with proteinuria: injections of active supernatants in rats renal artery is immediately followed by increase in proteinuria from 0,8 mg/h to 3,5 mg/h. Up to date, lymphokines have been studied in animals but seldom in human. Our results show that in human, variations in lymphokine production may be present. Pathogenic implications are now under study.

Animals↗