Search PubMed⌕ Search

Biomedical subjects

B Weidler

Publications and source records attributed to B Weidler.

44 records · Page 3Linked to original sources
PubMed1982

[Modified neuroleptanalgesia with buprenorphine].

A modification of neuroleptanalgesia by substituting fentanyl with buprenorphine is presented. Both anaesthesia techniques could be applied alternatively. We did not recognize any significant difference between the two groups concerning haemodynamics, the secretion of the so called stress hormones (antidiuretic hormone, cortisol) as well as the postoperative respiratory depression. The long lasting analgesia, which could be achieved by buprenorphine, can be advantageous in certain surgical interventions. The lack of a potent antagonist for buprenorphine in addition to its longer half-life for--not being of advantage in any anaesthesia--is discussed.

Adult↗
PubMed1982

[Variations in vasopressin (ADH)-levels during NLA combined with epidural fentanyl-analgesia (author's transl)].

10 patients scheduled for thoracic, abdominal or vascular surgery received anaesthesia as a combination of neuroleptanalgesia plus epidural opiate-analgesia. Antidiuretic hormone levels (ADH), serum-electrolytes (Na+, K+) and plasma osmolality have been investigated preoperatively (twice), intraoperatively (six times), during the first postoperative day (three times) and for five days postoperatively (once a day). There was a significant increase in ADH in all patients intra- and postoperatively, whereas serum-electrolytes and plasma-osmolality stayed within normal range. Maximum ADH-values were measured during the intraoperative period, postoperatively ADH-levels reached the normal range after 5 days. This increase in plasma-ADH-levels was not accompanied by typical haemodynamic changes. From the aspect of metabolic endocrine response to surgery, our results indicate no advantage of the combination of neurolept-analgesia plus epidural opiate-analgesia for the intraoperative period.

Aged↗
PubMed1981

[Plasma antidiuretic hormone level as an indicator of perioperative stress (Part I) (author's transl)].

The secretion of antidiuretic hormone (ADH) is mainly influenced by changes in osmolality and blood volume. In addition stress and surgical trauma may cause an elevation in plasma-ADH levels. In 20 patients scheduled for similar surgical procedures two different anaesthesia techniques were applied: in group 1 (n = 10) a combination of peridural anaesthesia and neuroleptanalgesia (PDA/NLA) was performed, in group 2 halothane anaesthesia with intubation was used. The perioperative control of plasma-ADH levels demonstrated a smaller increase in group 1 (PDA/NLA) compared to group 2 (Halothane), thus implicating a better attenuation of stress and pain.

Adolescent↗
PubMed1981

[Plasma-antidiuretic hormone level as indicator of postoperative stress (part II) (author's transl)].

For a period of five days serum levels of antidiuretic hormone (ADH) have been investigated postoperatively in a group of 20 patients with upper abdominal surgery. In addition serum electrolytes (Na+, K+) and plasma osmolality have been controlled regularly. Patients in group A (n = 10) received Fentanyl epidurally (0.1-0.2 mg diluted with 0.9% saline solution) for treatment of postoperative pain, whereas in group B (n = 10) systemic opiate therapy was performed by intramuscular application of piritramide (Dipidolor, 15-25 mg). There was a significant increase in ADH in all patients, whereas serum electrolytes (Na+, K+) and plasma osmolality stayed within normal range. ADH-levels in group A (epidural opiate), however, were significantly lower than mean values in group B (systemic opiate application). The postoperative increase in ADH is interpreted as a reaction to stress and trauma, being less pronounced, when epidural opiate therapy is performed for postoperative pain treatment.

Adult↗
PubMed1980

[Plasma amino acid levels during postoperative parenteral feeding with a complete nutritional solution].

During the course of postoperative parenteral feeding with a solution for total nutrition, 23 plasma amino acids were determined daily. After an initial fall in almost all of the amino acids, infusion of the total nutrition solution predominantly led to normalization of plasma levels. The known - albeit insulin-dependent - postoperative rise in the branched chain amino acids is described. Methionine, proline and phenylalanine show raised values. Possible causes for the variations in the plasma amino acid levels occuring in some instances are discussed. From our findings it appears favorable to commence parenteral nutrition as early as possible.

Amino Acids↗
PubMed1979

[Postoperative parenteral feeding with a complete solution].

Post-aggression metabolism leads even after moderately severe surgical interventions to postoperative catabolic derangement if there is inadequate replacement of carbohydrates, amino-acids and electrolytes. An investigation was carried out in 12 patients to see whether, and to what degree, the parenteral administration of a solution for total parenteral nutrition helped to bridge the postoperative nutrient deficiency. It is shown that with this form of nutrition and a complication-free postoperative course there was no imbalance of the nutritive metabolism.

Adult↗