Parenting challenges in the Millenium.
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Biomedical subjects
Publications and source records attributed to B Warnock.
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Swainsonine (1,2,8-trihydroxyoctahydroindolizine) was isolated from locoweed (Astragalus emoryanus) that grows in Texas. Using a biological assay as a measure of activity and purity, a relatively straightforward purification of the compound is described. The purified material was a potent inhibitor of jack bean alpha-mannosidase and also of glycoprotein processing. The positive ion electron impact mass spectra of this compound was identical to that of authentic swainsonine. Nuclear magnetic resonance analysis also confirmed that the material was swainsonine.