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Biomedical subjects

B Walther

Publications and source records attributed to B Walther.

At least 91 records · Page 5Linked to original sources
PubMed1981

[Joint diseases as the early clinical symptom of hemochromatosis].

In three patients arthropathy was the earliest symptom of hemochromatosis. Two of these patients had a precirrhotic stage of hemochromatosis. The liver histology of the third patient showed a beginning cirrhosis. The serum iron ranged from 212 to 260 micrograms/dl. The transferrin saturation was 95-100%. Serum iron and transferrin should be determined in all patients with arthralgias, since arthropathy may be the first clinical sign of hemochromatosis.

Diagnosis, Differential↗
PubMed1981

[Prognostication of neonates by compact polygraphy (author's transl)].

The polygraphic methods currently available for the prognostication of high risk neonates are timeconsuming, almost inaccessible to visual analysis and unsuited for clinical practice. A polygraphic method has been devised using a restricted number of standardized evaluation criteria arranged according to optimalisation principles with a reduction of observation time to three sleep cycles to an average of 90 minutes. Using this type of "compact polygraphy" 135 newborn infants were divided in a "simple" and a "complicated" group. Their follow-up over the first year of life showed that abnormal EEG-tracing and/or clinical manifestations of early epilepsy occurred only in infants classified as complicated. No seizures occurred in the simple group. 40% of the patients with complicated prognostication showed neurological abnormalities vs. 8% in the simple group, confirming the prognostic value of compact polygraphy. Since the risk of developing epilepsy was 20% in newborns with postnatal seizures and complicated prognostication, preventive treatment with antiepileptic drugs is recommended in these infants. On the other hand newborns with postnatal seizures and simple prognostication can be spared the longtime exposure to barbiturates or other anticonvulsants. From our data it appears that compact polygraphy is clinically feasible and has a higher predictive accuracy than any of other currently available practical prognostication methods.

Cerebral Cortex↗
PubMed1980

Morphology and metabolism of adult rat hepatocytes in primary culture.

Isolated hepatocytes obtained by collagenase perfusion of adult rat livers were seeded on collagen gels and kept in a chemically defined culture medium (except for the first 6 h of culture where 10% fetal calf serum was added). Cells adopted an epitheloid shape within 4 h and arranged themselves in a trabeculae-like pattern during the first 20 h of culture. In the electron microscope numerous tight junctions and bile capillaries were observed at sites of cell-to-cell contact. From metabolite analyses in the culture medium the following conclusions can be drawn: The cells continued to synthesize urea and ketone bodies for 5 days of culture. The cytosolic and mitochondrial redox states of the nicotinamide adenine nucleotide systsm were as in the liver in vivo and the oxygen supply of hepatocytes was sufficient under the culture conditions. Maximal velocities of ketogenesis from octanoate and of urea formation from ornithine plus ammonium chloride were stable during a 120 h culture period and compared well with rates found in the isolated perfused rat liver.

Animals↗
PubMed1979

[Interpretation of chest roentgenograms of intensive care patients. A comparison of pathoanatomical and roentgenographic findings (author's transl)].

Chest roentgenograms made within 24 hours of death were compared to the autopsy findings. Out of 150 unselected autopsy records of the years 1973/74 and 1976/77 50 and 91 cases respectively were suitable for evaluation. Since 1973/74 the radiographic technique has been considerably changed by the introduction of powerful condenser discharge equipment and the use of highly intensifying screens. Daily discussions with the physicians in charge of the intensive care unit and routine comparison of the pathological and radiological findings were also introduced. The success of these measures is reflected in the greater diagnostic accuracy in respect of the case material for the 1976/77 period. Comparison of the findings in cases of pulmonary embolism exposed the limitation of diagnostic radiology.

Humans↗
PubMed1978

Factors influencing essential fatty acid requirement in total parenteral nutrition (TPN).

Twenty patients, after major injuries or elective abdominal surgery, were studied with respect to essential fatty acids in total serum and lipoprotein fractions. The regimen of total parenteral nutrition was altered in its content of energy, carbohydrates or fat. In all patients the linoleic acid levels decreased and the 20:3/20:4 ratio increased. Serum low density lipoproteins developed remarkable alterations of the biochemical composition and of morphology by electronmicroscopy. The degree of these alterations depended on the kind of illness, the amount of carbohydrates infused, special hormonal situation due to surgery and linoleic acid supply. As a consequence of these results, the supply of a sufficient amount of linoleic acid should be considered in every case of total parenteral nutrition.

Adolescent↗
PubMed1978

[Pyruvate-dehydrogenase deficiency. Lethal course of the disease during infancy (author's transl)].

The course of pyruvate dehydrogenase deficiency in an infant is described. During pregnancy fetal movements were reduced, and since birth severe neurologic involvement was noticed. Permanent metabolic acidosis due to lactic acidemia as well as hyperpyruvic acidemia and hyperalaninemia were present. Alanine accumulated in CSF and urine, urinary excretion of lactate and pyruvate was highly elevated. Pyruvate dehydrogenase activity in a liver biopsy was only 5% of that for normal controls, and pyruvate decarboxylation by cultured fibroblasts was equally decreased. Therapy required permanent administration of bicarbonate. The administration of thiamine had no effect. The infant died within three months. Recently prenatal diagnosis during a subsequent pregnancy of the mother revealed normal results when pyruvate degradation with cultured amniotic fluid cells was investigated, and a healthy child was born.

Acidosis↗