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Biomedical subjects

B W Lloyd

Publications and source records attributed to B W Lloyd.

22 records · Page 2Linked to original sources

Long-term outcome for children with minimal-change nephrotic syndrome.

A retrospective study was undertaken to assess the outcome of a cohort of 183 unselected children who presented with the nephrotic syndrome between 1963 and 1969. All subjects showed minimal glomerular changes in biopsy samples and were given conventional steroid therapy. Information was available on 152 children, now aged 14-32 years. Activity persisted longer in patients presenting at an early age. The outcome for most of the children was favourable. Only 10 patients (5.5%), all of whom presented with initial symptoms before their 6th birthday, continued to have steroid-responsive relapses in adult life. There were 11 deaths, of which 7 (4% of the series) were from avoidable complications of the disorder.

Adolescent↗

Outcome of very-low-birthweight babies from Wolverhampton.

The outcome of the 159 babies weighing less than 1501 g who were born between 1975 and 1979 to women living in Wolverhampton was studied. 67 of the 68 survivors were assessed between the ages of 3 and 7 years and compared with a control group of 38 normal-birthweight siblings. Of those weighing less than 1501 g 91 (57%) died in infancy, 10 (6%) survived with major or moderate handicap, 15 (9%) had minor handicap, 42 (26%) were normal at follow-up, and 1 was untraced. 49% of the 51 school-age survivors were handicapped or were performing poorly at school, compared with 13% of 31 controls.

Child↗

Progressive neurological disorder associated with obstructive jaundice and vitamin E deficiency.

A ten-year-old girl had obstructive jaundice in the newborn period which persisted for 4 years despite choledochojejunostomy at 6 weeks. From the age of 6 years she developed a progressive neurological syndrome characterized mainly by dysarthria and ataxia. A causal relationship with her profound vitamin E deficiency seemed likely. Treatment with vitamin E over a 2 1/2 year period appeared to arrest the progression of the neurological deficit and subsequent increase in dosage produced some improvement in her ataxia.

Ataxia↗

Normal values for mature and immature neutrophils in very preterm babies.

Serial leucocyte counts were made on 24 babies of less than 33 weeks' gestation during the first 5 days of life. The values for mature neutrophils show two important differences from those obtained by previous workers studying term babies, in that the counts were much lower on the first day of life and showed a wider range of values at all ages. In contrast, immature neutrophil counts, expressed either as absolute values or as a proportion of the total neutrophil count (the I/T ratio), were similar to those found in previous studies and had a considerably narrower range.

Humans↗