Biomedical subjects
B Vincent
Publications and source records attributed to B Vincent.
[Not Available].
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Some marital-sexual concomitants of carcinoma of the cervix.
The responses of 50 cervical cancer patients to questions about marital and sexual adjustment are discussed. The subjects were predominantly poor, white women from rural areas or small towns. They had to travel 50 to 150 miles to a hospital where half were treated by radiotherapy and half by surgery. Their interview responses suggest five phases in attitudes and feelings from the time of the diagnosis until six months after treatment. Of 30 subjects who had a sex partner available and who completed the third of four interviews, 70% had either as much or more desire for coitus after treatment than before illness, and 57% had coitus either as frequently or more frequently after treatment than before illness.
[Dysplasia of temporary teeth in the premature or underweight at birth].
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[The "contraceptive" syndrome: clinical aspects and therapy].
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Differential catabolic fate of neuromedin N and neurotensin in the canine intestinal mucosa.
We have established the peptidase content of a P2 fraction (enriched in synaptosomes) and plasma membranes prepared from canine intestinal mucosa. Fourteen exo- and endopeptidases were assayed with fluorimetric or chromogenic substrates and identified by means of specific peptidase inhibitors. Post-proline dipeptidyl aminopeptidase IV, aminopeptidase M, and carboxypeptidase A were the most abundant exopeptidases, while aminopeptidases A and B, dipeptidyl aminopeptidase, pyroglutamyl peptide hydrolase I, and carboxypeptidase B displayed little, if any, activity. Endopeptidase 24.11 was the only endopeptidase that was detected in high amount. By contrast, proline endopeptidase exhibited a low activity, while angiotensin-converting enzyme, endopeptidase 24.15, endopeptidase 24.16, and cathepsin B and D-like activities were not detected. The catabolic rates of the two related neuropeptides, neurotensin (NT) and neuromedin N (NN), established that NN was inactivated 16 to 24 times faster than NT by plasma membrane and P2 fractions, respectively. Furthermore, the two peptides underwent qualitatively distinct mechanisms of degradation. A phosphoramidon-sensitive formation of NT(1-10) was detected as the major NT catabolite, indicating that NT was susceptible to an endoproteolytic cleavage elicited by endopeptidase 24.11. By contrast, NN was inactivated by the action of an exopeptidase at its N-terminus, leading to the formation of [des-Lys1]NN. The occurrence of this NN metabolite was prevented by bestatin and actinonin, but not by the aminopeptidase B inhibitor, arphamenine B, indicating that the release of the N-terminal residue of NN was likely due to aminopeptidase M.(ABSTRACT TRUNCATED AT 250 WORDS)
Plasma cerebrosides in stroke and multiple sclerosis.
This investigation was conducted to determine whether or not plasma galactosyl ceramides were elevated in patients with stroke and multiple sclerosis, and to determine glycosyl ceramide concentrations in older, normal subjects. It was hypothesized that central nervous system destruction, like that which occurs in stroke or in the demyelination characteristic of multiple sclerosis, might be reflected by changes in plasma glycosyl ceramides, specifically by an increased percentage of galactosyl ceramide. Glycosyl ceramides were analyzed in duplicate 10 ml aliquots of plasma from each of seven patients with stroke, five patients with multiple sclerosis and five control subjects age-matched with stroke patients. Mean percentages of galactosyl ceramide for both controls (11.06 percent) and multiple sclerosis (11.40 percent) were strikingly similar. The percent of galactosyl ceramides for stroke was slightly elevated (14.32 percent) but there were no significant differences at the p=greater than 0.05 level.
[Revision of total hip prosthesis].
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[Value of periodic abstention as a method of birth control].
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