Search PubMed⌕ Search

Biomedical subjects

B Vidic

Publications and source records attributed to B Vidic.

At least 37 records · Page 2Linked to original sources
PubMed1990

Disk fragment migration.

This report analyzes the most frequently observed migration paths of disk fragments in 47 patients who had extruded or sequestered disks. Observations are based principally on magnetic resonance (MR) images. When disk fragments moved in a superior (42%) or inferior (40%) direction from the donor disk, the displaced disk components were most frequently (94%) dislodged into the right or left half of the anterior epidural space (AES) and rarely straddled the midline. To explain this phenomenon, the authors investigated the anatomy of the AES by dissecting four cadaver specimens and reviewing 300 MR images of the spine. They conclude that the migrating path of a disk fragment is determined by the anatomy of the AES, a fairly well-defined space delimited posteriorly by the posterior longitudinal ligament and by membranes laterally attached to it. It consists of two compartments separated by a sagitally aligned septum. During migration, sequestered disk fragments usually stay in these compartments.

Cervical Vertebrae↗
PubMed1990

[Long-term biometric results in glaucoma in children].

In a retrospective study 30 eyes of 18 patients suffering from developmental glaucoma (primary congenital glaucoma, Sturge Weber syndrome, juvenile glaucoma) were examined after surgery. The mean follow-up period was 13 years. Eyeball length and anterior chamber depth were measured by means of echooculometry. Biometric data (echooculometry, corneal diameter, cup to disk ratio) were compared with psychophysic data (visual acuity, visual field). Up to an axial length of 26 mm, myopia caused by elongation of the eyeball is compensated by the weak refractive power of the large cornea. In cases with an eyeball length of more than 27 mm, excessive myopia was found. There is a linear correlation between corneal diameter and axial length of the eyeball. In all cases with an axial length of more than 27 mm only low vision was achieved. From our results can be concluded that 27 mm is the "critical" eyeball length which carries a grave prognosis. Due to the late (minimum 4 years) onset of the disease, all the operated eyes with Sturge Weber syndrome and juvenile glaucoma were in normal size.

Adolescent↗
PubMed1989

[Diagnosis of ocular Chlamydia infections. Experiences with 2 test systems].

It is well known that both direct and indirect test systems are available for identifying chlamydial infections. In the author's laboratory two of these systems were compared by examining conjunctival scrapings, sera, and tears from more than 150 patients with chronic, therapy-resistant conjunctivitis. The principal criteria considered were the time and technical effort involved and the sensitivity and specificity of these tests in ophthalmology. According to the authors' findings, direct identification of the pathogens with FITC-labeled monoclonal antibodies is useful for diagnosing fresh infections. In cases of chronic disease, however, the indirect serologic test is of greater value, because it is usually impossible to isolate the viruses. This test shows specific IgA and IgG antibodies in serum and tears that do not occur before the tenth (IgA) or 30th (IgG) day after infection. The sensitivity and specificity of both tests seem to be on a par with the culture system, which is still the "gold standard" for diagnosis. For a secure diagnosis both test systems should be used, though of course always taking the clinical picture into consideration.

Adult↗
PubMed1985

Clinical experience with povidone-iodine eye drops in patients with conjunctivitis and keratoconjunctivitis.

In 40 patients with conjunctivitis or keratoconjunctivitis povidone-iodine eye drops were either administered alone or in combination with a cortisone preparation. The antimicrobial activity in the concentration administered was adequate for the elimination of the causative organisms from the conjunctival sac in the majority of patients, and the preparation was well tolerated.

Adult↗
PubMed1984

[Relative discharge of tears by the upper and lower lacrimal ducts].

Forty eyes were studied in order to establish the relative function of the upper and lower lacrimal ducts. Following artificial occlusion first of the upper and then of the lower lacrimal ducts. Schirmer's No. 1 test was performed. The wetting of the test strips was used as an indirect measure of tear discharge. Higher quantities were discharged from the upper ducts of 17 eyes and from the lower ducts of 15. In 8 eyes the discharge from the upper and lower ducts was equal. The findings in this study thus disprove the commonly held belief that the upper lacrimal duct is plays a subordinate role in tear discharge.

Adolescent↗
PubMed1982

[Partial canaliculus transplantation--further results].

Partial canaliculus transplantation is a suitable method of substituting the canaliculus when the nasal lower lid region has been damaged by tumor. Two cases are described, illustrating that the area of indication may be extended to substitution surgery of parts of the canaliculus next to the lacrimal sac and that, analogously to complete lid transplantation, the method can be combined with sliding plasty. During the observation period, which lasted for 17 to 20 months, the partial canaliculus transplantations followed up proved to be patent.

Adult↗
PubMed1981

[A live intraocular parasite (author's transl)].

Using the first film documentation of such a case, the differential diagnostic and therapeutic difficulties in a case of live intravitreal Filaria are discussed. The visual acuity of the affected eye was unimpaired. The parasite was destroyed by systemic anthelmintic therapy. The only functional damage to the eye was that the visual field was concentrically reduced to approximately 40 degrees.

Aged↗
PubMed1981

[Development of retinal vein thrombosis after argon laser photocoagulation (author's transl)].

In this paper 21 cases of branch vein thrombosis and 15 cases of central retinal vein thrombosis treated by argon laser photocoagulation are compared with an untreated control group. The visual prognosis after photocoagulation was no better in the treated group than in the control group. After central retinal vein occlusion, three cases of hemorrhagic glaucoma (20%) were observed in the control group but there was no rubeosis iridis or hemorrhagic glaucoma in the group treated by argon laser therapy.

Aged↗
PubMed1981

[Rehabilitation after serious perforating eye injuries (author's transl)].

In a recent study of perforating eye injuries the authors found that in 21% there was no binocular function. To prevent complications arising from this, early fitting of hard contact lenses seems necessary. The problems of fitting contact lenses to posttraumatically aphakic eyes are discussed, with special regard to aniseikonia.

Aphakia↗
PubMed1980

[Sjögren's reticular pigmentary dystrophy (author's transl)].

An examination of two families with reticular pigmentary dystrophy of the retina is reported, and typical findings are reviewed. Visual actuity, visual fields, dark adaptation and color vision were normal; the photopic ERG was normal or subnormal, while the scotopic ERG was normal. Only the EOG findings were pathologic in all of the subjects examined. A description of the various forms of reticular dystrophy and of its differential diagnosis is followed by a discussion concerning the classification of all varieties of this disease as patterned dystrophies of the pigment epithelium.

Adult↗
PubMed1980

[Observations of the course of branch and central venous occlusions (author's transl)].

Electro-ophthalmological responses determined with EOG, photopic and scotopic ERG, flash VEP's and pattern reversal VEP's, in combination with fluorescein angiography and computerized perimetry, were evaluated in seven patients suffering from branch vein occlusions and in eight patients suffering from occlusions of the central retinal vein. The findings were as follows: In cases of branch vein occlusion and central retinal venous occlusion with good prognosis there was a normal or slightly subnormal response in all electro-ophthalmological examinations. In the cases of central retinal venous occlusion with poor prognosis, likely to lead to destruction of the nervous structures of the retina, the response was considerably weaker as regards photopic and scotopic b-waves, and especially VECP's.

Electrooculography↗
PubMedDate not supplied

In vitro studies on the role of the peripheral-type benzodiazepine receptor in steroidogenesis.

In vitro studies using isolated cells, mitochondria and submitochondrial fractions demonstrated that in steroid synthesizing cells, the peripheral-type benzodiazepine receptor (PBR) is an outer mitochondrial membrane protein, preferentially located in the outer/inner membrane contact sites, involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane, the rate-determining step in steroid biosynthesis. Mitochondrial PBR ligand binding characteristics and topography are sensitive to hormone treatment suggesting a role of PBR in the regulation of hormone-mediated steroidogenesis. Targeted disruption of the PBR gene in Leydig cells in vitro resulted in the arrest of cholesterol transport into mitochondria and steroid formation; transfection of the mutant cells with a PBR cDNA rescued steroidogenesis demonstrating an obligatory role for PBR in cholesterol transport. Molecular modeling of PBR suggested that it might function as a channel for cholesterol. This hypothesis was tested in a bacterial system devoid of PBR and cholesterol. Cholesterol uptake and transport by these cells was induced upon PBR expression. Amino acid deletion followed by site-directed mutagenesis studies and expression of mutant PBRs demonstrated the presence in the cytoplasmic carboxy-terminus of the receptor of a cholesterol recognition/interaction amino acid consensus sequence. This amino acid sequence may help for recruiting the cholesterol coming from intracellular sites to the mitochondria.

Animals↗
PubMedDate not supplied

Anatomy and development of the cricoid: serial-section whole organ study of perinatal larynges.

Whole organ serial-section study contributes to our understanding of neonatal intubation injury by demonstrating the previously undescribed "V" configuration of the posterior cricoid lamina; this may be readily correlated with subarytenoid paramedian intubation injury. This technique also permits detailed study of an anomalous larynx and permits the precise identification of a "tracheal" anomaly as a cricoid malformation. The need for a fetal staging system is reemphasized.

Humans↗
PubMedDate not supplied

Structure, function and regulation of the mitochondrial peripheral-type benzodiazepine receptor.

Steroid biosynthesis begins with the transfer of cholesterol from intracellular stores into mitochondria. Through in vitro and in vivo studies using various steroidogenic cell models and with the help of pharmacological, biochemical, morphological and molecular approaches we demonstrated that the peripheral-type benzodiazepine receptor (PBR) is an 18 kDa mitochondrial protein that interacts with other proteins in the outer mitochondrial membrane to form a multimeric complex. PBR is required for the binding, uptake and release, upon ligand activation, of the substrate cholesterol. Thus, cholesterol becomes available to the inner mitochondrial membrane P450scc where steroid biosynthesis begins. The presence of mitochondrial PBR is also critical in maintaining outer mitochondrial membrane stability and in preventing apoptosis. Considering these functions of PBR and the fact that PBR is a ubiquitous protein, it is suggested that this drug receptor may serve as a target to control various mitochondrial and cell functions and to protect against experimentally or pathologically induced mitochondrial and cell toxicity.

Animals↗