The immune responses in actinomycetoma lesions caused by Streptomyces somaliensis in Sudan were characterized by immunohistochemistry during 1997-1998. In sections stained with haematoxylin and eosin, the inflammatory reaction around the grain was of 2 types. In type I there were 3 zones: a neutrophil zone immediately around the grain, an intermediate zone containing mainly macrophages, and a peripheral zone consisting of lymphocytes and plasma cells. Zone 1 stained positively for CD15 (neutrophils), zone 2 for CD68 (macrophages) and CD3 (T lymphocytes), and zone 3 for CD20 (B lymphocytes). In the type II reaction, there was no neutrophil zone, the grains being surrounded only by macrophages and giant cells. This was confirmed by immunohistochemistry, which demonstrated the presence of CD3 positive cells. Immunoglobulins G and M and complement were demonstrated on the surface of the grain and on filaments inside the grain. Neutrophils and macrophages were recruited into the lesion by complement and were involved in the fragmentation of the grain. The cytokine profile in the lesion and regional lymph nodes was of a dominant Th2 pattern (interleukins-10 and 4).

Actinomycetales Infections↗

PubMedDate not supplied

The distribution of lipids in malignant hypertensive fibrinoid necrosis.

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Animals↗

PubMedDate not supplied

The healing of cricothyroidostomy in pigs. A morphological study.

The advantages and disadvantages with cricothyroidotomy have been discussed by several authors during the last 12 years. The frequency of complications differs considerably probably depending on indications for surgery and methods of follow-up. In our own human material (253 patients cricothyroidotomized and 79 of 102 alive after 6 months followed up) there has been no case of laryngeal or tracheal stenosis. The aim of this study was to analyse the effect of the inflammatory granulation tissue on the surrounding tissues in 8 cricothyroidotomized pigs, and to analyse the regeneration of the mucosa and the healing with special regard to development of stenosis. Despite pronounced stomal infection and formation of granulation tissue we found no case of stenosis, no injuries of the cartilage and a complete regeneration of the ciliated epithelium.

Animals↗

PubMedDate not supplied

Pattern of bladder cancer in the Sudan and its relation to schistosomiasis: a study of 255 vesical carcinomas.

Two hundred and fifty five vesical carcinomas in Sudanese patients are analysed as regards frequency, age, sex, local geographical distribution, morphological features and association with urinary schistosomiasis. The findings are compared with those from other series. It is concluded that the pattern of bladder cancer in the Sudan in general conforms to that reported from regions endemic for schistosomiasis and differs significantly from that seen in non-schistosomal regions. The limitations in the study are noted.

Adenocarcinoma↗

PubMedDate not supplied

Polymyositis associated with asymptomatic primary biliary cirrhosis.

We here describe a case of polymyositis associated with asymptomatic primary biliary cirrhosis and a high titer of antimitochondrial antibodies. The patient had remarkable multiorgan engagement: polyarthritis, pericarditis, pleuritis and tachyarrythmia. Atypical changes, suggestive of mitochondrial damage, were observed in a muscle biopsy specimen. Under treatment with azathioprine and steroids, the disease had a favourable outcome.

Anti-Inflammatory Agents↗