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Biomedical subjects

B V Lewis

Publications and source records attributed to B V Lewis.

At least 37 records · Page 2Linked to original sources

Screening for endometrial carcinoma using a negative pressure intra-uterine "jet wash".

Endometrial jet washings, which permit lavage of the uterine cavity by sterile isotonic saline under negative pressure, were performed as a screening technique in one hundred and one selected patients attending a gynaecological clinic. The material collected was assessed by both cytological and histological methods. A formal curettage was subsequently performed on all patients and the results of the two methods compared. Fifteen per cent of patients were diagnosed as having an endometrial carcinoma by jet washing and these results were confirmed by the histological reports from curettage. There were no false positive nor false negative results. It is suggested that endometrial jet washing is a simple and convenient method of screening women for endometrial carcinoma and gives diagnostic results comparable to those obtained by a conventional curettage.

Curettage↗

A clinical service for prenatal diagnosis.

A centralised clinical prenatal diagnostic service has been established and the results of amniocentesis in 174 patients are discussed. Termination of pregnancy was performed in 3 patients on the basis of cytogenetic abnormalities (47,XXY, 47,XXX, 47,XY 21+): in 2 patients with anencephalic fetuses on the basis of alpha-fetoprotein and ultrasound investigations, and 1 patient with fetal Hurler's syndrome. One mother, aged 45, refused amniocentesis and gave birth to a child with Down syndrome. Amniocentesis was followed by fetal death and abortion in 3 patients, all of whom had repeat amniocentesis. Cytogenetic results were not obtained from cell-culture in 9 out of 155 patients, but it was possible to explain all but 2 of the failures. An unexplained error in fetal sex determination occurred once.

Abortion, Spontaneous↗

A comparison of techniques for determining prenatal sex from liquor amnii.

The cellular content of amniotic fluid is primarily composed of desquamated squamous cells. Depending on their site of origin and maturation, the staining characteristics of the nuclei and cytoplasm differ. Prenatal foetal sex was determined by comparing the proportion of anucleate pyknotic nuclei to vesicular nuclei using Papanicolaou's stain and the proportion of red cells to blue cells using Shorr's stain.Both techniques allow an accurate assessment of prenatal sex to be made after 30 week's gestation. There is a close correlation between the two methods.

Amniotic Fluid↗