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Biomedical subjects

B Tiran

Publications and source records attributed to B Tiran.

22 records · Page 2Linked to original sources
PubMed1991

Simple determination of iodine in small specimens of thyroid tissue.

This work describes a simple photometric determination of the iodine concentration in thyroid tissue, a method based on the well-known catalytic Sandell-Kolthoff reaction. The modified ceric arsenite reaction is very sensitive and does not require complicated laboratory equipment. It can be performed in any routine clinical laboratory if instructions are followed strictly. By means of this method iodine concentration can be determined even in small specimens, for instance puncture samples of thyroid tissue or thyroid glands of small animals (mouse). Previous to the analysis, the tissue is digested in a mixture of sodium chlorate and perchloric acid at 100 degrees C. Using this manner of digestion between 94 and 110% of iodine in the sample were recovered. Comparison with neutron activation analysis showed excellent agreement of the obtained values.

Humans↗
PubMedDate not supplied

Age dependency of selenium and cadmium content in human liver, kidney, and thyroid.

Selenium and cadmium concentrations were investigated in 60 autopsy tissue samples obtained from fetal life up to adulthood (defined in this study as 25-87 y of age) in Styria, a moderately industrialized region in Austria that has a low selenium supply. During the first 2 y after birth, median liver selenium concentrations were slightly lower (i.e., 1.5 nmol/g wet weight) than concentrations found in fetal life (i.e., 2.9 nmol/g) and adulthood (2.1 nmol/g). Whereas in the fetal period median selenium content in the kidney cortex (2.1 nmol/g) and the thyroid gland (1.6 nmol/g) was lower than that found in the liver, the reverse was true for adults (i.e., kidney, 5.5 nmol/g; thyroid, 4.3 nmol/g). Tissue cadmium concentrations approached 0 during gestation. Accumulation in the kidney and liver commenced immediately after birth. In the thyroid gland of adults, significantly higher concentrations of cadmium were found. Median concentrations in adults showed no statistical significant age dependency (i.e., liver, 7.6 nmol/g; kidney, 59.8 nmol/g; thyroid, 11.2 nmol/g). In summary, the data revealed very low tissue selenium concentrations and low cadmium burdens for the Styrian population that was not exposed occupationally.

Adolescent↗
PubMedDate not supplied

Selenium and glutathione peroxidase levels in healthy infants and children in Austria and the influence of nutrition regimens on these levels.

Serum selenium values were investigated in 56 formula-fed and in 18 wholly breast-fed infants. In 14 of these infants, glutathione peroxidase (GSH-Px) was also investigated. Determination of selenium and GSH-Px was also done in umbilical cord blood of seven healthy newborns. In another 109 infants aged 1-15 yr, serum selenium values were investigated. A continuous fall of serum selenium values was noted in the first 3 mo of life. Low levels continued until the age of 6 mo with a mean of 36% of the umbilical cord vein level. Breast-fed babies of GSH-Px showed a less pronounced fall in selenium and had significantly higher levels of GSH-Px. GSH-Px activity was reduced from age 5 to 8 mo. Feeding of beikost caused a rise in the level of selenium. Children in the age groups 1-15 yr still had a significantly lower serum selenium level than adults.

Adolescent↗