Search PubMed⌕ Search

Biomedical subjects

B Thuesen

Publications and source records attributed to B Thuesen.

At least 19 recordsLinked to original sources
PubMed1998

Scalds in children caused by water from electrical kettles: effect of prevention through information.

Electrical kettles (el-kettles) were virtually unknown in Danish households in the mid-1980s, but have since become more common. In 1996, (65 per cent of all Danish households had an el-kettle. As the number of el-kettles have increased, so have the number of scalds caused by water from toppled el-kettles. The first patient with an el-kettle scald was admitted to the Burns Centre at Hvidovre hospital in 1988. From 1988 to 1993 29 patients were admitted with this type of scald; 15 patients in 1993 alone. All the patients were toddlers 5-30 months of age. When el-kettle scalds were compared to scalds caused by other mechanisms in children under 5 years of age, it was found that the former occurred to younger children than the latter (60 per cent of el-kettle scalded children were less than 1 year of age compared to 28 per cent scalded by other means), the scalds were more extensive (median of TBSA were 13 per cent and 6 per cent, respectively), and the scalds were deeper (53 per cent and 24 per cent, respectively, needed skin-grafting). In 1993 campaigns were started to inform parents that the cord of the el-kettle should be short and not hang over the edge of the table. In the following years a considerable decrease in the number of el-kettle scalds was found. When the number of expected el-kettle scalds was estimated from the number of Danish households having an el-kettle, it was found that more than half the expected number of el-kettle scalds were avoided.

Accidents, Home↗
PubMed1996

[Scalds in children caused by water from toppled electrical kettles. Mechanisms, costs and preventive measures].

Since 1988 a new type of burns in children has been recorded at the Burns Centre at Hvidovre Hospital in Copenhagen, being scalds caused by water from toppled electrical kettles (el-kettles). The children with el-kettle scalds were younger and their injuries more severe than those of children whose scalds had other causes. During the six year period 1988 to 1993, a total of 29 children (0-3 years) have been admitted with scalds caused by el-kettles, 15 children alone in 1993. The costs for treatment have been more than 3 million Danish kroner, 1.8 million DKK alone in 1993. From 1993 preventive measures were taken to reduce the number of this type of scalds. Since the number of households with el-kettles in Denmark is on the increase, an increasing number of toddlers with severe scalds could be anticipated. However, a fall in the number of children admitted was registered in 1994 (four children) and 1995 (six children).

Accidents, Home↗
PubMed1995

Capsular contracture after breast reconstruction with the tissue expansion technique. A comparison of smooth and textured silicone breast prostheses.

Twenty consecutive breast reconstructions were done by the expansion technique. Either textured or smooth expander prostheses were used followed by silicone implants. Histological samples were taken from the capsule when the expander was removed and the implant inserted. The results show no difference in capsular formation between the groups, although the microscopic evaluations from the group with textured prostheses showed considerable numbers of silicone droplets. The patients were generally pleased with the results even though some reconstructed breasts were slightly firm when evaluated postoperatively.

Adult↗
PubMed1993

Outbreak of infection in a burns unit due to Pseudomonas aeruginosa originating from contaminated tubing used for irrigation of patients.

Five patients with extensive deep burns developed septicaemia due to Pseudomonas aeruginosa serogroup O-7.8 and phage type 21 or 21/188 shortly after they had been admitted to hospital. Four other burned patients became colonized with the same strain. The source of infection was contaminated tap water used for irrigation of the burns, as part of the first-aid treatment which the patients received when entering the hospital. Contamination was restricted to showers and tubing that were permanently connected to the taps, and the outbreak stopped after they had been disinfected. Tubing and showers used for irrigation of burns should be dismantled and heat-disinfected after each patient and not reconnected to the taps until immediately before the next treatment. Taps used for irrigation of burns should be monitored regularly for the presence of P. aeruginosa and other potentially pathogenic bacteria. Routine typing of P. aeruginosa isolates from burned patients is indicated in order to detect and eliminate hidden sources of infection.

Adult↗
PubMed1992

[Epidemiological studies on scalded children admitted to the burns unit at the Hvidovre hospital during 1981-1990].

During the ten year period 1981 to 1990, a total of 436 children aged 0-5 years were admitted for scalds at the Burns Unit of Hvidovre Hospital. We did not find any reduction in the number of admissions during this period nor was any change in the patterns of scalds found. Water, tea and coffee were the main causal agents of scalds and the dominant group of scalded children was between the ages one to two years. In 37% of cases, the scalds required grafting and the average stay in hospital was 16 days. The background for this unchanged pattern could be that the prophylactive campaigns have been insufficient.

Burns↗
PubMed1992

Sexual function and somatopsychic reactions after local excision of vulvar intra-epithelial neoplasia.

Eighteen patients, under the age of 60 years, who have been treated with local excision of the vulva, participated in the study in which sexual function and somatopsychic reactions were evaluated by personal interviews. Furthermore both objective and subjective cosmetic results were registered. After this type of operation, fewer than one-third of the patients had postoperative sexual and somatopsychic problems, whereas more than half of the patients undergoing vulvectomy did report such problems. Fourteen out of 18 patients were satisfied with the cosmetic result and in 12 of the patients no disfiguration was found. This study shows that local excision of intra-epithelial neoplasia of the vulva is far less sexually traumatic than is vulvectomy.

Adult↗
PubMed1991

[Scalding among children caused by electric kettles. An increasing problem].

The object of this work is briefly to draw attention to a new type of accident as the cause of scalding in children. The increasing use of electric kettles has resulted in an increased number of scalding accidents caused by these kettles. Within a period of six months, eight children under the age of five years were treated in the Department for Burns, Hvidovre Hospital on account of overturned electric kettles, a form of accident which had not previously been observed in this department. All of the children had pulled the cable. Seven out of eight children were admitted to hospital and transplantations proved necessary in three children.

Accidents, Home↗
PubMed1990

Histamine-induced paradoxical GH response to TRH/GnRH in men and women: dependence on gonadal steroid hormones.

A stimulatory GH response to TRH and GnRH occurs frequently in patients with various pathological conditions, but is absent in normal subjects. We have previously shown that histamine induced a paradoxical GH response to TRH in normal men. Since gonadal steroids influence GH secretion, we investigated whether infusion of histamine might induce a GH response to combined administration of TRH (200 micrograms) and GnRH (100 micrograms) in 6 normal women during the early follicular and luteal phase of the same menstrual cycle and in 7 normal men. Histamine had no effect on basal GH secretion in men or in women during the two phases of the menstrual cycle. However, compared with saline, histamine induced a GH response to TRH/GnRH in men (GH peak: 5.5 +/- 1.0 vs 1.4 +/- 0.3 micrograms/l; p less than 0.01) and in women during the luteal phase (GH peak: 5.2 +/- 1.6 vs 1.5 +/- 0.4 micrograms/l; p less than 0.025), but not during the early follicular phase of the cycle (GH peak: 1.7 +/- 0.5 vs 1.6 +/- 0.3 micrograms/l). In luteal-phase women the GH response to TRH/GnRH correlated with the serum estradiol-17 beta level (GH area/E2: r = 0.98; p less than 0.005) and the serum estrone level (GH area/E1: r = 0.81; p less than 0.05). In men the GH response to TRH/GnRH did not correlate with estrogen or androgen levels. We conclude that high physiological levels of estrogens are pertinent to the activation of a histamine-induced GH response to TRH/GnRH in women, whereas the role of androgens and estrogens for the induction of the response in men seems more complex.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

Plasma concentrations of pituitary and peripheral hormones during ranitidine treatment for two years in men with duodenal ulcer.

The effects of treatment for 2 years with the histamine H2-receptor antagonist ranitidine (100 or 200 mg b.d. for 6 weeks followed by 100 or 200 mg daily) on plasma concentrations of pituitary and peripheral hormones in ten men with duodenal ulcer have been investigated. Stimulation tests with TRH 200 micrograms i.v. and LHRH 100 micrograms i.v. were performed before, during (6 and 24 months), and at least 6 months after treatment. Basal and TRH-stimulated prolactin (PRL) secretion was marginally reduced after treatment for 6 months, but not for 24 months. The LH response to LHRH was slightly increased after treatment for 6 months and 24 months and after the end of treatment. The plasma concentrations of TSH, FSH, cortisol, androgenic hormones, and thyroid hormones did not change significantly during treatment. No adverse effects were reported during the observation period. The few, minor changes in pituitary hormone concentrations were all within the reference range. They may be related to ranitidine treatment, but are more likely to be due to age-dependent alterations in hormone secretion. It is concluded that long-term treatment with ranitidine does not cause major changes in circulating hormone concentrations.

Adult↗
PubMed1988

Temporal responses of cutaneous blood flow and plasma catecholamine concentrations to histamine H1- or H2-receptor stimulation in man.

We have studied the effect of histamine and H1- or H2-receptor antagonists on cutaneous blood flow and catecholamine release in man. Histamine was infused alone or in combination with mepyramine, an H1-antagonist or cimetidine, an H2-antagonist for 2 h. Cutaneous blood flow was measured continuously with a laser Doppler flowmeter, and noradrenaline and adrenaline concentrations were determined in blood samples drawn every 15 min. The infusion of histamine caused an immediate and sustained vasodilatation. The Concomitant infusion of mepyramine prevented the immediate vasodilatation, but had no effect on the sustained response. The Concomitant infusion of cimetidine was without effect on the immediate vasodilatation, but abolished the sustained response. Infusion of the antagonists alone had no effect on cutaneous blood flow. Histamine caused a rapid and sustained increase in plasma noradrenaline, while the increase during concomitant H1-receptor blockade was delayed but achieved the level observed during the histamine infusion. The response to histamine during H2-receptor blockade was small and transient. The rise in plasma adrenaline was not significant. These findings suggest that histamine causes an immediate cutaneous vasodilatation through H1-receptors and a more sustained response through H2-receptors. The vasodilatation is accompanied by an increase in plasma catecholamine concentrations. Despite the continuous infusion of histamine, blood flow decreased during the last hour of histamine infusion, while the plasma noradrenaline concentration was still elevated.

Adult↗