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Biomedical subjects

B Thiele

Publications and source records attributed to B Thiele.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Immunoglobulin D--new insights into its structure and function].

The IgD is unique with regard to its structure, differences between species, genetic organization and behaviour in the immune response. With the successful analysis of the structure a new picture of the function has been emerged. The function of the membrane-bound IgD as a trigger receptor of B cells is qualitatively different from the mIgM. The secreted form could act as an intercellular messenger in the network regulation of the immune response. The mechanisms of the induction and maintenance of the immunological memory and tolerance remain unclear.

B-Lymphocytes↗
PubMed1985

[Preliminary results of Re-PUVA therapy in cutaneous T-cell lymphomas].

Eight patients with T-cell-lymphoma of the skin (6 mycosis fungoides, 2 parapsoriasis variegata) were treated with Tigason in combination with PUVA-therapy. The daily dose of Tigason was 50-100 mg. There was complete regression of skin lesions in three patients, partial regression in three patients, and an improvement in two patients.

Combined Modality Therapy↗
PubMed1984

[Classical form of Kaposi sarcoma: immunology and interferon therapy].

T-lymphocytes and their subsets were determined in three patients with classical Kaposi's sarcoma. A reduction of pan-T-lymphocytes, including both a reduction of T-helper and T-suppressor cells, was found in one patient. None of the patients showed a reduction of the T-helper/T-suppressor cell ratio, as described in the lymphadenopathic disseminated type of Kaposi's sarcoma. Intradermal testing with tuberculin and trichophytin gave no indication of humoral immunodeficiency or anergy. In addition to electron beam irradiation, one female patient was treated with rIFN-alpha-interferon, 6 X 10(6) IU 3 times a week over a period of 3 months, and 18 X 10(6) IU 3 times weekly over 1 month. Under this therapy, irradiated as well as nonirradiated lesions become flatter, reduced in size and faded. The number of T-suppressor cells diminished.

Aged↗
PubMed1984

[Areas of low-threshold motor units in the m. extensor digitorum communis--study using concentric needle electrodes].

By a slight voluntary contraction, recording sites were chosen where the electrode picked up activity of only one motor unit. Then the needle was moved in minute steps (as controlled by a slide-gauge) through the area of the motor unit under investigation. Hereby the recorded motor unit potential underwent characteristic changes (Fig. 1). The amplitude was maximal within the centre of the motor unit and decreased sharply within 1 to 2 mm (Fig. 2, 3). Single spike components, when discernible within the motor unit potential complex, could be traced for about 1 mm. With regards to the amplitude profile curves of the whole motor unit potential, it is discussed whether a population of fairly small low-threshold motor units exists in the EDC containing as few as 20-50 muscle fibres scattered over an area with a diameter of 1-2 mm.

Action Potentials↗
PubMed1984

[Motor unit potentials of the biceps muscle in comparing right and left parameters in right-handed subjects].

Motor unit potentials recorded by a concentric needle electrode in the right and left m. biceps brachii were statistically compared with regards to mean potential duration and amplitude. With the Wilcoxon-test the mean duration showed no statistically significant right/left difference, whereas the mean potential amplitude turned out to be significantly higher in the left m. biceps (Fig. 1, 2, table 1). The fibre density measured by a single fibre EMG electrode was found to be higher in the left m. biceps as well (1.23 as compared to 1.18 in the right). Therefore it is assumed that muscle fibre hypertrophy in muscles of the right arm in right-handed subjects leads to a decrease in fibre density within the motor units. The mean distance between active muscle fibres and electrode seems to be a more important factor with regards to the unit potential's amplitude than the muscle fibre diameter itself.

Action Potentials↗
PubMed1984

Human atherosclerosis. I. Cell constitution and characteristics of advanced lesions of the superficial femoral artery.

This study represents a systematic analysis of the fine-structural characteristics of atherosclerotic lesions of the superficial femoral artery in man together with the growth characteristics in culture of the smooth muscle cells derived from these lesions. Occlusive fibrous atherosclerotic plaques were obtained from 29 male patients at the time of bypass surgery for occlusion of the superficial femoral artery and were studied by light and transmission electron microscopy. The occluded segment of each artery was obtained immediately after removal from the patient and examined with sterile techniques, and representative segments were fixed for light- and electron-microscopic study. Adjacent segments were used for dissection of the lesion away from the underlying media, and smooth muscle cells were cultured from lesion and nonlesion areas and compared in terms of their growth responses to increasing concentrations of a pool of human whole blood serum. The majority of the lesions were fibroproliferative and contained relatively little lipid. The fibrous cap that covered each lesion consisted of a special form of dense connective tissue that contained flat, pancake-shaped smooth muscle cells in a lacunalike space. This space consisted of concentric layers of basement membrane, collagen fibrils, and proteoglycan. The majority of the cells beneath the fibrous cap were smooth muscle cells mixed with small but varying numbers of macrophages. Most of the lesions were occluded by a thrombus, which had undergone organization and recanalization. A small number of the lesions had deep lipid deposits together with foci of degeneration and calcification. The occluded thrombi contained smooth muscle cells and a larger proportion of macrophages than the lesions themselves. The in vitro growth properties of the smooth muscle cells isolated from the lesion and the underlying media suggested that the lesion cells had senesced, compared with the medial smooth muscle cells derived from the same artery.

Aged↗
PubMed1983

[Chemotherapy of cutaneous T-cell lymphomas with arotinoid].

Five patients with T-cell lymphoma of the skin (mycosis fungoides; Sézary syndrome) were given parenterally arotinoid ethyl ester (Ro 13-6298) at a daily dose of 0.5-4.0 micrograms/kg body weight, to a total dose of 20 mg over maximally 31 weeks. In three patients, among them one with tumourous mycosis fungoides, there was complete regression of the cutaneous lesions. In another patient the cutaneous changes, some of them with ulceration, regressed so that there were only residual infiltrates. In the case of the Sézary syndrome there was no response. Most important side-effects of treatment were cheilitis, moist and sticky skin, paronychia and dry mucosae. The most serious side-effect was pain in muscles, joints and bones. There were no significant changes in biochemical values during the treatment.

Adult↗
PubMed1983

Intranuclear tonofilament-like filaments in skin carcinoma.

Electron microscopical investigations of untreated solar keratosis, squamous cell carcinoma, and Bowen carcinoma showed intranuclear bundles of intermediate filaments in suprabasal keratinocytes. We found evidence that the filaments are incorporated into the nucleus during atypical mitosis.

Aged↗
PubMed1983

[Cheilitis glandularis simplex].

Cheilitis glandularis simplex is a rather rare disease which has to be differentiated from cheilitis granulomatosa. The histological characteristics of cheilitis glandularis simplex are hypertrophy and hyperplasia of mucous and/or heterotopic salivary glands. The therapy is the excision of the tumor.

Adult↗
PubMed1982

Temporary intraluminal shunts: resolution of a management dilemma in complex vascular injuries.

Complex vascular injuries of the extremities in which acute arterial insufficiency is combined with severe or prolonged shock, extended periods of ischemia, or associated fractures or soft-tissue injuries have unacceptably high limb loss rates, frequently because the allowable warm ischemia time for skeletal muscle is exceeded before adequate revascularization. In a 1-year period, ten patients with complex vascular injuries identified at our metropolitan trauma center underwent routine introduction of temporary plastic intravascular shunts at the site of vessel disruption, thus permitting immediate limb revascularization. This rapid reperfusion permitted appropriate attention to be directed toward skeletal fixation, soft-tissue debridement, and other procedures without the urgency usually associated with the presence of acute limb ischemia. Following various local and distant orthopedic or general surgical procedures, arterial and venous continuity were uneventfully re-established. This experience suggests that the routine use of plastic intraluminal shunts in complex vascular injuries of the extremities has the distinct potential of reducing the excess morbidity from prolonged acute arterial insufficiency noted in such injuries.

Adolescent↗