Biomedical subjects

B Thalme

Publications and source records attributed to B Thalme.

At least 37 records · Page 2Linked to original sources

PubMed1975

Studies on closure of the ductus arteriosus. XII. In utero effect of indomethacin and sodium salicylate in rats and rabbits.

Administration of prostaglandin synthetase inhibitors to pregnant does and dams in late gestation was followed by in utero contraction of the fetal ductus arteriosus when studied by the whole-body freezing method. In the rat this contraction was well established within 6 h and persisted up to 36 h following 15 mg/kg indomethacin p.o. No effect was observed in the 18 d rat fetus but fetuses at 20 d and 22 d of gestation responded significantly to indomethacin. Doses of indomethacin approaching clinical usage (2.5 mg/kg also caused a positive response in utero. The rat was found to be sensitive also to sodium salicylate and in the rabbit both indomethacin and sodium salicylate were effective. Exposure in utero to prostaglandin synthetase inhibitors with resulting contraction of the ductus may seriously disturb cardiac function in the fetus.

Animals↗

PubMed1975

Infants of mothers with a high and of mothers with a low insulin response to glucose infusion. Glucose tolerance, insulin response and clinical appearance during the early neonatal period.

Diabetic mothers affect their offspring during pregnancy, sometimes giving rise to the complete symptoms of diabetic fetopathia with the typical appearance of the child high birth weight, hyperinsulinism, etc. Some of these traits have also been reported to appear in the infants some time before the onset of diabetes in the mother, but no prospective study of infants born to truly prediabetic mothers has yet been reported. Thus it is not possible to say whether or not the previously reported effects are related to an undetected, subclinical diabetes in the mother. A prospective study of the insulin reponse to glucose during pregnancy [9] has been previously published, which included 11 women with a low insulin response to glucose infusion (GIT) - a prediabetic type of insulin response according to the definition of Cerasi and Luft [5] - and a control group of 14 women with a high insulin response to glucose infusion. In the following the neonatal findings in these 13 infants of low insulin responders (ILR) aand 14 infants of high responders (IHR) are reported...

Birth Weight↗

PubMed1975

Glucose tolerance in newborn infants of healthy mothers: its relationship to the mothers' insulin response to glucose infusion.

It has earlier been postulated that a low insulin response to a glucose infusion is characteristic for the prediabetic individual (Cerasi & Luft 1967c). There is also evidence that some infants of individuals with low insulin response might have a carbohydrate metabolism that is in some respects similar to that of newborn infants to diabetic mothers (Edström et al. 1974). In the present study 15 infants to low insulin responders (ILR) and 22 infants to high insulin responders (IHR) were subjected to an intravenous glucose load (IVGTT) at 2-24 h age. A significant difference in glucose tolerance was found between the groups, the mean k-value for the ILR being 1.39 plus or minus 0.41 and that for the IHR 1.05 plus or minus 0.09 (P smaller than 0.05). No mothers were found to have a gestational diabetes (with the possible exception of one low insulin responders) but during late pregnancy the mean k-value at IVGTT in the low responders decreased from non-pregnant values (the mean difference being 0.41 plus or minus 0.20, P smaller 0.025) while the high responders did not show a corresponding decrease (mean difference 0.12 plus or minus 0.25, P greater than 0.05). No other differences between the groups of infants that could influence the k-value could be found apart from the mothers being low or high insulin responders. Our findings show that a low insulin response in the mothers might effect the glucose tolerance of the foetus even in the absence of continuous maternal hyperglycaemia in late pregnancy.

Birth Weight↗

PubMed1975

Acid-base and electrolyte balance in infants of diabetic mothers. Vaginal delivery versus caesarean section.

The acid-base and electrolyte balance of 30 women studied at delivery and in their infants during the first 48 h. 18 women were diabetics, 10 of these were delivered vaginally (DMvag) and 8 by elective caesarean section (DMcs). 12 healthy women were vaginally delivered (HMvag). The infants of diabetic mothers (IDM) received active infusion therapy. At birth the DMvag and their infants (IDMvag) had a more pronounced metabolic acidosis than the DMcs and their babies (IDMcs). The largest metabolic acidosis occurred, however, in the group of HMvag and their infants (IHMvag). After birth no significant differences were obtained in the acid-base and electrolyte balance between IDMvag and IDMcs. The plasma potassium level remained lower in IDM than in IHM. The study stress the importance of adequate management of diabetes in pregnancy in combination with active intravenous therapy during delivery and to the infant in the immediate neonatal period. The slightly larger metabolic acidosis seen in combination with vaginal delivery suggests that this mode of delivery should not be attempted uncritically in diabetic women.

Acid-Base Equilibrium↗

PubMed1974